David Paul MRC Laboratory of Molecular Biology
37 protocols

Thirupugal Govindarajan National Institutes of Health
7 protocols

Reviewer
Sylvain Baron
  • Cellecta
Research focus
  • Cancer biology
2 Protocols reviewed
Screening Method for CRISPR/Cas9 Inhibition of a Human DNA Virus: Herpes Simplex Virus
The efficiency of cleavage of individual CRISPR/Cas9-sgRNAs remains difficult to predict based on the CRISPR target sequence alone. Different intracellular environments (dependent on cell type or cell cycle state for example) may affect sgRNA ...
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CRISPR/Cas9 + AAV-mediated Intra-embryonic Gene Knocking in Mice
Intra-embryo genome editing by CRISPR/Cas9 has enabled rapid generation of gene knockout animals. However, large fragment knock-in directly into embryos’ genome is still difficult, especially without microinjection of donor DNA. Viral vectors are ...
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