protein biochemistry, DNA replication and repair, DNA helicase-polymerase, DNA replisome, immunotherapies, T cell engagers, antibody engineering
https://scholar.google.com/citations?hl=en&user=2-jgT1gAAAAJ&view_op=list_works&authuser=1Peer reviewed Publications
• Perera, H. M., Trakselis, M. A. Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding, elife. 2019; 8: e46096
• Perera, H. M., Trakselis, M. A., Site-specific DNA Mapping Using Azidophenacyl Bromide to Map the Binding Orientation of Proteins, Bio-protocol. 2020; 10(12):e3649
• Perera, H. M., Wezley, G. C., Kankanamage, R. N. T., Kankanamge, L. S. P., The Impact of COVID-19 on the Future of Science Carriers, Chem. Res. Toxicol. 2020; 0c00436
• Perera, H. M., Trakselis, M. A., Determining Translocation Orientation of Helicases, Methods, 2021, 204: 160-171
• Behrmann, Perera, H. M., M. S., Hoang, J. H., Jones, P., Venkat, T., Trakselis, M. A., Targeted chromosomal Escherichia coli:dnaB exterior surface mutations control replication speed to maintain genomic stability and organismal fitness, PLOS genetics, 2021, 17(11): e1009886
• Kankanamge, L. S. P., Perera, H. M., Griffin, W. C., Genome Repair takes a Spotlight during the ACS TOXI meeting, Chem. Res. Toxicol. 2021; 0c00438
• Perera J. K. H. M., Dassanayaka R.S., Endoplasmic Reticulum Stress in Unfolded Protein Response Signaling, Biochemistry and Analytical Biochemistry. 2015; 4(3)
Book Chapter
• Perera, H. M., Behrmann, M. S., Hoang, J. H., Wezley, G. C., Trakselis, M. A. Contacts and Context that Regulate DNA Helicase Unwinding and Replisome Progression, Enzymes. 2019; 45 :183-223
Conference Abstracts
• Perera, H. M., Trakselis, M. A., Defining the loading orientation of SsoMCM on fork DNA- FASEB SRC, Machines on Genes, Snowmass, CO, 2018
• Perera, H. M., Trakselis, M. A., Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding, Gordon Research Conference, Newry, ME, 2019
• Behrmann, M. S., Hoang, J. H., Perera, H. M., Trakselis, M. A., Investigating the mechanism and impact of helicase regulation in vivo by targeted chromosomal E. coli DnaB exterior surface mutations, Gordon Research Conference, Newry, ME, 2019
• Trakselis, M. A., Perera, H. M., Megan Behrmann, M. S., Hoang, J. H., Contacts and Conformations that Regulate Hexameric Helicases at the Replication fork, Experimental Biology, American Society for Biochemistry and Molecular Biology (ASBMB), 2020
• Taylor, M.K., Perera, H. M., and Trakselis, M. A., Purification of E. coli DNA directed- DNA Polymerase III core enzyme, Undergraduate Research and Scholarly Achievement (URSA), Baylor University, 2020
• Hoang, J. H., Behrmann, M. S., Perera, H. M., Trakselis, M. A., DNA unwinding among diverse helicases, Undergraduate Research and Scholarly Achievement (URSA), Baylor University, 2020
• Perera, H. M., Trakselis, M. A., Molecular Contacts and Kinetic Control within the Replisome maintain Coupled DNA Unwinding and Synthesis, Experimental Biology, American Society for Biochemistry and Molecular Biology (ASBMB), 2021
• Welikala, M. U., Behrmann, M. S., Perera, H. M., Trakselis, M. A., Tau mediated coupling interactions between Pol III core and DnaB is essential for cellular and genomic stability (Experimental Biology, American Society for Biochemistry and Molecular Biology (ASBMB), 2022