Chiara Ambrogio University of Turin
48 protocols

Karem Court Houston Methodist Research Institute
6 protocols

Kuldeep Attri Eppley Institute of Cancer Research, UNMC
3 protocols

Shibali Das Washington University in St. Louis
2 protocols

Enrico Patrucco
  • Research scientist, Universita' degli Studi di Torino
Research focus
  • Molecular biology
  • Our research lab is intereseted in the mechanisms of initiation, growth and therapy s Anaplastic Lymphoma Kinase (ALK)-driven cancers, that include Anaplastic Large Cell Lymphoma (ALCL), Non-Small Cell Lung Cancers (NSCLC) and other solid tumors. Our approach is mostly pre-clinical and includes in-vitro and in-vivo experimantal models.


PhD, University of Torino, 2004

Lab information

Roberto Chiarle


• Baldacci S, Grégoire V, Patrucco E, Chiarle R, Jamme P, Wasielewski E, Descarpentries C, Copin MC, Awad MM, Cortot AB. Complete and prolonged response to anti-PD1 therapy in an ALK rearranged lung adenocarcinoma. – Lung Cancer. 2020 May 27, DOI:

• Blasco RB*, Patrucco E*, Tai WT, Chiarle R. Comment on “ALK is a therapeutic target for lethal sepsis” – Sci Transl Med. 2018 Dec 12;10(471). PMID: 30541790

• Menotti M, Ambrogio C, Cheong TC, Pighi C, Mota I, Cassel SH, Compagno M, Wang Q, Dall'Olio R, Minero VG, Poggio T, Sharma GG, Patrucco E, Mastini C, Choudhari R, Pich A, Zamo A, Piva R, Giliani S, Mologni L, Collings CK, Kadoch C, Gambacorti-Passerini C, Notarangelo LD, Anton IM, Voena C, Chiarle R. Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma. - Nat Med. 2019 Jan;25(1):130-140. doi: 10.1038/s41591-018-0262-9. Epub 2018 Dec 3. PMID: 30510251

• Sharma GG, Mota I, Mologni L, Patrucco E, Gambacorti-Passerini C, Chiarle R. Tumor Resistance against ALK Targeted Therapy-Where It Comes From and Where It Goes. - Cancers (Basel). 2018 Feb 28;10(3). pii: E62. doi: 10.3390/cancers10030062. Review. PMID: 29495603

• Poomvanicha M, Matthes J, Domes K, Patrucco E, Angermeier E, Laugwitz KL, Schneider T, Hofmann F. Beta-adrenergic regulation of the heart expressing the Ser1700A/Thr1704A mutated Cav1.2 channel. - J Mol Cell Cardiol. 2017 Oct;111:10-16. doi: 10.1016/j.yjmcc.2017.07.119. Epub 2017 Aug 1.PMID: 28778765

• Domes K, Patrucco E, Loga F, Dietrich A, Birnbaumer L, Wegener JW, Hofmann F, Murine cardiac growth, TRPC channels, and cGMP kinase I - Pflugers Arch. Eur. Journ. Physiol. 2014 Dec 30. [Epub ahead of print] PMID:25547873

• Patrucco E, Domes K, Sbroggio` M, Blaich A, Schlossmann J, Desch M, Rybalkin SD, Beavo JA, Lukowski RD, Hofmann F. Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation pf AngII-induced cardiac hypertrophy and fibrosis - Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12925-9. doi: 10.1073/pnas.1414364111. Epub 2014 Aug 19.,

• Shimizu-Albergine M, Tsai LC, Patrucco E, Beavo JA. cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis. - Mol Pharmacol. 2012 Apr;81(4):556-66. Epub 2012 Jan 9.

• Adamo CM, Dai DF, Percival JM, Minami E, Willis MS, Patrucco E, Froehner SC, Beavo JA. Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy - Proc Natl Acad Sci USA (2010) Nov 2; 107(44):19079-83

• Patrucco E, Albergine MS, Santana LF, Beavo JA. Phosphodiesterase 8A (PDE8A) regulates excitationcontraction coupling in ventricular myocytes. - J Mol Cell Cardiol. (2010) Aug;49(2):330-3.

• Costa C, Barberis L, Ambrogio C, Manazza AD, Patrucco E, Azzolino O, Neilsen PO, Ciraolo E, Altruda F, Prestwich GD, Chiarle R, Wymann M, Ridley A, Hirsch E. Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma. - Proc Natl Acad Sci U S A. (2007) Sep 4;104(36):14354-9

• Lionetti V; Lisi A; Patrucco E; De Giuli P; Milazzo MG; Ceci S; Wymann M; Lena A; Gremigni V; Fanelli V; Hirsch E; Ranieri VM. Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury. – Criti Care Med. (2006) Jan;34(1):134-41.

• Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Storto M, Azzolino O, Brancaccio M, Colussi G, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsch E, Lembo G. Protection from Angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ. - Journ. Exp Med. (2005) Apr 18;201(8):1217-28.

• Alloatti G, Marcantoni A, Levi R, Gallo MP, Del Sorbo L, Patrucco E, Barberis L, Malan D, Azzolino O, Wymann M, Hirsch E, Montrucchio G. Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through G(i)-independent downregulation of cAMP level. - FEBS Lett. (2005) Jan 3;579(1):133-140.

• Lupia E, Goffi A, De Giuli P, Azzolino O, Bosco O, Patrucco E, Vivaldo MC, Ricca M, Wymann MP, Hirsch E, Montrucchio G, Emanuelli G. Ablation of phosphoinositol 3-kinase 􀀀 modulates the severity of acute pancreatitis. - American Journal of Pathology (2004) Dec;165(6):2003-11

• Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M, Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F, Wetzker R, Wymann MP, Lembo G, Hirsch E.PI3Kγ modulates the cardiac response to chronic pressure overload by kinase-dependent and independent effects. - Cell. (2004) Aug 6;118(3):375-87.

• Hirsch E, Wymann MP, Patrucco E, Tolosano E, Bulgarelli-Leva G, Marengo S, Rocchi M, Altruda F. Analysis of the Murine Phosphoinositide 3-Kinase 􀀀 Gene. - Gene 256 (2000).

• Tolosano E, Hirsch E, Patrucco E, Camaschella C, Navone R, Silengo L, Altruda F.Defective Recovery and Severe Renal Damage After Acute Hemolysis in Hemopexin-Deficient Mice – Blood 94,11 (1999).

Online Publications:
• Patrucco E, Kraynik S, Beavo JA. Phosphodiesterase 8A, cAMP-specific. UCSD-Nature Molecule Pages (2012). (doi:10.6072/H0.MP.A001760.01)
10 Protocols reviewed
Murine Monocyte and Macrophage Culture
Authors:  Simone M. Haag and Aditya Murthy, date: 03/20/2021, view: 4103, Q&A: 0

Myeloid progenitors in the bone marrow generate monocytes, macrophages, granulocytes and most dendritic cells. Even though these innate immune cells are part of the same lineage, each cell type plays a specific and critical role in tissue

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In-vitro GLP-1 Release Assay Using STC-1 Cells
Authors:  Liu Qi, Tan Shuai, Jia Da, Burstein Ezra and Sifuentes-Dominguez Luis, date: 08/20/2020, view: 2396, Q&A: 0
Enteroendocrine cells (EECs) are known chemosensors in the gastrointestinal (GI) epithelium. They release a diversity of gut hormones in response to various stimuli. Here, we report an in-vitro assay to measure GLP-1 release from cultured ...
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