Giusy Tornillo Cardiff University
27 protocols

Pengpeng Li Boston Children’s Hospital
30 protocols

sujan mondal University of Pittsburgh
6 protocols

Surabhi Sonam Institut Jacques Monod
6 protocols

Alak Manna
  • Research associate, Mayo Clinic
Research focus
  • Cancer biology
  • Hematology/Oncology; development of immunotherapeutics; cancer immunology


PhD, University of Calcutta, India, 2015

Lab information

Translational Cancer Research, Immunotherapy


1. Manna A, Saha P, Sarkar A, Mukhopadhyay D, Bauri AK, Kumar D, Das P, Chattopadhyay S, Chatterjee M. Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line. PLoS One. 2012; 7(5):e36938.
2. Manna A, De Sarkar S, De S, Bauri AK, Chattopadhyay S, Chatterjee M. The variable chemotherapeutic response of Malabaricone-A in leukemic and solid tumor cell lines depends on the degree of redox imbalance. Phytomedicine. 2015; 22(7-8):713-23.
3. Manna A, Bauri AK, Chattopadhyay S, Chatterjee M. Generation of redox imbalance mediates the cytotoxic effect of Malabaricone-A in a multidrug resistant cell line. Anticancer Agents in Medicinal Chemistry. 2015; 15(9):1156-63.
4. Manna A, De Sarkar S, De S, Bauri AK, Chattopadhyay S, Chatterjee M. Impact of MAPK and PI3K/AKT signaling pathways on Malabaricone-A induced cytotoxicity in U937, a histiocytic lymphoma cell line. Int Immunopharmacol. 2016; 39: 34-40.
5. Manna A, Chattopadhyay S, Chatterjee M. Plant derived pro-oxidants as potential anti-cancer therapeutics. Studies in Natural Products Chemistry. 2016; 50: 81-129.
6. Paulus A#, Manna A#, Akhtar S, Paulus SM, Sharma M, Coignet MV, Jiang L, Roy V, Witzig TE, Ansell SM, Allan J, Furman R, Aulakh S, Manochakian R, Ailawadhi S, Chanan-Khan AA, Sher T. Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells. Br J Haematol. 2018. doi: 10.1111/bjh.15515. (In press; equal contribution).
7. De S, Manna A, Kundu S, De Sarkar S, Chatterjee U, Sen T, Chattopadhyay S, Chatterjee M. Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways. J Pharmacol Exp Ther. 2017; 360(2):249-259.
8. Mukhopadhyay D, Das NK, De Sarkar S, Manna A, Ganguly DN, Barbhuiya JN, Maitra AK, Hazra A, Chatterjee M. Evaluation of serological markers to monitor the disease status of Indian post kala-azar dermal leishmaniasis. Trans R Soc Trop Med Hyg. 2012; 106(11): 668-76.
9. Chatterjee S, Das S, Chakraborty P, Manna A, Chatterjee M, Choudhuri SK. Myeloid derived suppressor cells (MDSCs) can induce the generation of Th17 response from naïve CD4+ T cells. Immunobiology. 2013; 218(5): 718-24.
10. Sarkar D, Kundu S, De S, Hariharan C, Saha P, Manna A, Chattopadhyay S, Chatterjee M. The antioxidant activity of allylpyrocatechol is mediated via decreased generation of free radicals along with escalation of antioxidant mechanisms. Phytother Res. 2013; 27(3): 324-9.
11. Kumar D, Das B, Sen R, Kundu P, Manna A, Sarkar A, Chowdhury C, Chatterjee M, Das P. Andrographolide Analogue Induces Apoptosis and Autophagy Mediated CellDeath in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway. PLoS One. 2015; 10(10): e0139657.
12. Mitra S, Pati AK, Manna A, Ghosh A, Sen S, Chatterjee S, Chatterjee M. A study of the free radical scavenging effects of Piper betle leaf extract in patients with vitiligo. Indian J Dermatol Venereol Leprol. 2017; 83(1):40-46.
13. Paulus A, Akhtar S, Yousaf H, Manna A, Paulus SM, Bashir Y, Caulfield TR, Kuranz-Blake M, Chitta K, Wang X, Asmann Y, Hudec R, Springer W, Ailawadhi S, Chanan-Khan A. Waldenstrom macroglobulinemia cells devoid of BTK(C481S) or CXCR4(WHIM-like) mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment. Blood Cancer J. 2017; 7(5):e565.
14. Datta S, Dasgupta D, Ghosh A, Ghosh S, Manna A, Datta S, Chatterjee M, Chowdhury A, Banerjee S. Oncogenic potential of hepatitis B virus subgenotype D1 surpasses D3: significance in the development of hepatocellular carcinoma. Carcinogenesis. 2018; 39(2):283-292.
15. Laali KL, Greves W, Correa-Smits SJ, Zwarycz AT, Bunge SD, Borosky GL, Manna A, Paulus A, Chanan-Khan A. Novel Fluorinated Curcuminoids and their Pyrazole and Isoxazole Derivatives: Synthesis, Structural Studies, Computational/Docking and in-vitro Bioassay. Journal of Fluorine Chemistry. 2018; 206; 82-98.
16. Laali KK, Greves WJ, Zwarycz AT, Correa Smits SJ, Troendle FJ, Borosky GL, Akhtar S, Manna A, Paulus A, Chanan-Khan A, Nukaya M, Kennedy GD. Synthesis, Computational Docking Study, and Biological Evaluation of a Library of Heterocyclic Curcuminoids with Remarkable Antitumor Activity. ChemMedChem. 2018. doi: 10.1002/cmdc.201800320. (In press).
2 Protocols reviewed
Collagenase-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry
Authors:  Cathrin J. Czupalla, Hanadie Yousef, Tony Wyss-Coray and Eugene C. Butcher, date: 11/20/2018, view: 7795, Q&A: 0
The brain endothelium is a highly specialized vascular structure that maintains the activity and integrity of the central nervous system (CNS). Previous studies have reported that the integrity of the brain endothelium is compromised in a plethora ...
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Generation of Human Mesenchymal Stem Cell 3D Spheroids Using Low-binding Plates
The 3D culture of human mesenchymal stem cells (hMSCs) represents a more physiological environment than classical 2D culture and has been used to enhance the MSC secretome or extend cell survival after transplantation. Here we describe a simple and ...
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4 Protocols edited
Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice
Authors:  Nick van Gastel, Jessica B. Spinelli, Marcia C. Haigis and David T. Scadden, date: 10/05/2021, view: 778, Q&A: 0

Once thought to be a mere consequence of the state of a cell, intermediary metabolism is now recognized as a key regulator of mammalian cell fate and function. In addition, cell metabolism is often disturbed in malignancies such as cancer, and

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Tyramide Signal-Amplified Immunofluorescence of MYCN and MYC in Human Tissue Specimens and Cell Line Cultures
Authors:  Johanna M. Schafer and Jennifer A. Pietenpol, date: 07/05/2020, view: 1858, Q&A: 0
MYC family members, MYC, MYCN, and MYCL, are oncogenic transcription factors that regulate the expression of genes involved in normal development, cell growth, proliferation, metabolism, and survival. While MYC is amplified and/or overexpressed ...
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