Jonathan Coquet Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Sweden
1 protocol
Alka Mehra Institute of Genomics and Integrative Biology
45 protocols

Gal Haimovich Weizmann Institute of Science Rehovot
125 protocols

Kate Hannan The Australian National University
15 protocols

Lokesh Kalekar eGenesis Inc
19 protocols

Chris Tibbitt
  • Post-Doc, Karolinska Institutet
Research focus
  • - T helper cell differentiation
    - ILC differentiation
    - Allergy
    -Single Cell RNA Sequencing
  • 1 Author merit


PhD, Newcastle University, 2015

Lab information

Jenny Mjösberg Lab

Junjie Ma^, Christopher A Tibbitt^, Susanna K Georén, Murray Christian, Ben Murrell, Lars-Olaf Cardell, Claus Bachert, Jonathan M Coquet. ‘Single cell analysis pinpoints populations of cytotoxic CD4 T cells and an IL-10+CD109+ Th2 cell population in nasal polyps’. (2021). Science Immunology, 6 (62), eabg6356. ^denotes joint authorship.

Leona Rohrbeck, Monika Adori, Shan Wang, Chenfei He, Christopher A. Tibbitt, Mark Chernyshev, Madle Sirel, Ulf Ribacke, Mohammad Bohooly-Y, Mikael Karlsson, Gunilla Karlsson Hedstam, Jonathan M Coquet. ’GPR43 regulates marginal zone B‐cell responses to foreign and endogenous antigens.’ (2021). Immunology and Cell Biology 99, no. 2: 234-243.

Banu Batyrova, Fien Luwaert, Panagiota Maravelia, Yuria Miyabayashi, Neha Vashist, Julian M. Stark, Sara Y. Soori, Christopher A Tibbitt, Paulo Reise, Jonthan M Coquet, Benedict Chambers. ’PD‐1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator‐activated receptor‐γ.’ (2020). Immunity, inflammation and disease 8, no. 1: 8-23.*

Christopher A Tibbitt^, Julian M Stark^, Liesbet Martens, Junjie Ma, Jeffrey E Mold, Kim Deswarte, Ganna Oliynk, Xiaogang Feng, Bart N Lambrecht, Pieter De Bleser, Susanne Nylén, Hamida Hammad, Marie Aresenian Henriksson, Yvan Saeys, Jonathan M Coquet (2019). ‘Single-Cell RNA Sequencing of the T helper response to House Dust Mites reveals defines a distinct gene expression signature in airway Th2 cells’. Immunity 51, pp. 1-16. ^Denotes joint authorship.

Christian Seitz, Sang Liu, Katrin Klocke, Anne-Laure Joly, Paulo V Czarnewski, Christopher A Tibbitt, Sara M Parigi, Lisa S Westerberg, Jonathan M Coquet, Eduardo J Villablanca, Kasja Wing, John Andersson. (2019) ‘Multi-facted inhibition of dendritic cell function by CD4+ Foxp3+ regulatory T cells’. Journal of Autoimmunity, 98, pp.86-94.

Monica Centa, Kajsa E Prokopec, Manasa G Garimella, Katrin Habir, Lisa Hofste, Julian M Stark, Albert Dahdah, Christopher A Tibbitt, Konstantinos A Polyzos, Anton Gisterå, Daniel K Johansson, Nobuyo N Maeda, Göran K Hansson, Daniel FJ Ketelhuth, Jonathan M Coquet, Christoph J Binder, Mikael CI Karlsson, Stephen Malin, (2018) ‘Acute loss of apolipoprotein E triggers an autoimmune response that accerlerates atherosclerosis’. Arteriosclerosis, thrombosis, and vascular biology, 38 (8), pp.e145-e158.

Ting Chen^, Christopher A Tibbitt^, Xiaogang Feng, Julian M Stark, Leona Rohrbeck, Lisa Rausch, Saikiran K Sedimbi, Mikael CI Karlsson, Bart N Lambrecht, Gunilla B Karlsson Hedestam, Rudi W Hendriks, Benedict J Chambers, Susanne Nylén, Jonathan M Coquet. (2017) ‘PPAR-γ promotes type 2 immune responses in allergy and nematode infection. Science Immunology, 2(9), p.eaal5196. ^Denotes joint authorship.

Christopher A Tibbitt, Jane Falconer, Jeroen Stoop, Willem van Eden, John H Robinson, Catharien MU Hilkens. (2016) ‘Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance’. European Journal of Immunology, 46 (7), pp1633-1643.

Christopher A Tibbitt, Jonathan M Coquet. ‘House Dust Mite Extract and Cytokine Instillation of Mouse Airways and Subsequent Cellular Analysis’. Bio-protocol 6(14): e1875. DOI: 10.21769/BioProtoc.1875.

Jeroen N Stoop, Christopher A Tibbitt, Willem van Eden, John H Robinson, Catharien MU Hilkens. (2013) ‘The choice of adjuvant determines the cytokine profile of T cells in proteoglycan-induced arthritis but does not influence disease severity’. Immunology, 138 (1), pp.68-75.

Review articles

Julian M Stark, Jonathan M Coquet, Christopher A Tibbitt. ‘The role of PPAR-g in allergic diseases’. Current Allergy and Asthma Reports. Accepted.

Julian M Stark^, Christopher A Tibbitt^, Jonathan M Coquet. 'The Metabolic Requirements of Th2 Cell Differentiation'. (2019). Front. Immunol. 10:2318. . ^Denotes joint authorship.
1 Protocol published
House Dust Mite Extract and Cytokine Instillation of Mouse Airways and Subsequent Cellular Analysis
Authors:  Chris Tibbitt and Jonathan M. Coquet, date: 07/20/2016, view: 11256, Q&A: 1
Asthma is a complex disease of the airways primarily mediated by T helper 2 cells and innate lymphoid type 2 cells (Licona et al.,2013). Mice do not develop spontaneous asthma and therefore models have been developed for the assessment of ...
6 Protocols reviewed
Evaluating Human Natural Killer Cells Antibody-dependent Cellular Cytotoxicity (ADCC) Using Plate-bound Anti-CD16 Antibodies
Author:  Weiru Liu, date: 01/05/2022, view: 1486, Q&A: 0

Natural killer (NK) cells are large granular lymphocytes that keep in check the health of neighboring cells through a large array of intrinsically expressed germline-coded receptors. Most importantly, CD16 is a low affinity Fc receptor for IgG that

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Using the Cecal Ligation and Puncture Model of Sepsis to Induce Rats to Multiple Organ Dysfunction

Sepsis is a dysregulated hyperinflammatory disease caused by infection. Sepsis leads to multiple organ dysfunction syndrome (MODS), which is associated with high rates of mortality. The cecal ligation and puncture (CLP) model has been widely used in

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