Principal Investigator

Lab members

About Our Lab

Affiliation
Stanford
Research Interests
Function and mechanism of the eukaryotic chaperonin TRiC Chaperone networks, ribosome biogenesis and co-translational folding Protein homeostasis, quality-control and selective degradation Misfolding and Aggregation Diseases Protein Folding and Homeostasis in Viral Infection

The long term goal of our research is to understand how proteins fold in living cells. The Frydman lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.

Protocol Portfolio