Education

Ph.D., Rutgers University, U.S.A, 2005

Current position

Professor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China, 2009

Publications (since2014)

1. Huang, C., Zhang, Z., Chen, L., Lee, H., Ayrapetov, M., Zhao, T., Hao, Y., Gao, J., Yang, C., Mehta, G.,  Zhuang, Z., Zhang, X., Hu, G., Chin, E.  Distinct Roles of Acetylation within the N- and C-terminal Domains of Src in STAT3-mediated Tumorigenesis Regulation. Cancer Res, in press.
2. Zhuang, X., Zhang, H., Li, X., Li, X., Cong, M., Peng, F., Yu, J., Zhang, X., Yang, Q. and Hu, G. (2017). Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1. Nat Cell Biol 19(10): 1274-1285.
3. Huang, H., Zhang, W., Pan, Y., Gao, Y., Deng, L., Li, F., Li, F., Ma, X., Hou, S., Xu, J., Li, P., Li, X., Hu, G., Li, C., Chen, H., Zhang, L. and Ji, H. (2017). YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation. Cancer Res 77(21): 5769-5781.
   
4. Hu, J., Li, G., Zhang, P., Zhuang, X. and Hu, G. (2017). A CD44v(+) subpopulation of breast cancer stem-like cells with enhanced lung metastasis capacity. Cell Death Dis 8(3): e2679.
   
5. Li, N., Xue, W., Yuan, H., Dong, B., Ding, Y., Liu, Y., Jiang, M., Kan, S., Sun, T., Ren, J., Pan, Q., Li, X., Zhang, P., Hu, G., Wang, Y., Wang, X., Li, Q. and Qin, J. (2017). AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest 127(4): 1284-1302.
   
6. Panayotopoulou, E. G., Muller, A. K., Borries, M., Busch, H., Hu, G. and Lev, S. (2017). Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells. Oncotarget 8(28): 45088-45104.
   
7. Li, G., Li, M., Hu, J., Lei, R., Xiong, H., Ji, H., Yin, H., Wei, Q. and Hu, G. (2017). The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene 36(7): 989-998.
   
8. Yu, P. F., Huang, Y., Xu, C. L., Lin, L. Y., Han, Y. Y., Sun, W. H., Hu, G. H., Rabson, A. B., Wang, Y. and Shi, Y. F. (2017). Downregulation of CXCL12 in mesenchymal stromal cells by TGFbeta promotes breast cancer metastasis. Oncogene 36(6): 840-849.
   
9. Yu, J., Lei, R., Zhuang, X., Li, X., Li, G., Lev, S., Segura, M.F., Zhang, X., Hu, G. (2016). MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun 7:13884.
10. Chen, X., Cao, X., Sun, X., Lei, R., Chen, P., Zhao, Y., Jiang, Y., Yin, J., Chen, R., Ye, D., Wang, Q., Liu, Z., Liu, S., Cheng, C., Mao, J., Hou, Y., Wang, M., Siebenlist, U., Eugene Chin, Y., Wang, Y., Cao, L., Hu, G. and Zhang, X. (2016). Bcl-3 regulates TGFbeta signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death Dis 7(12): e2508.
    
11. Liang, Y., Hu, J., Li, J., Liu, Y., Yu, J., Zhuang, X., Mu, L., Kong, X., Hong, D., Yang, Q. and Hu, G. (2015). Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer. Cancer Res 75(17): 3672-3680.
    
12. Chen, F., Zhuang, X., Lin, L., Yu, P., Wang, Y., Shi, Y., Hu, G. and Sun, Y. (2015). New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med 13: 45.
    
13. Zhou, Y., Wu, K., Jiang, J., Huang, J., Zhang, P., Zhu, Y., Hu, G., Lang, J., Shi, Y., Hu, L., Huang, T. and Kong, X. (2015). Integrative analysis reveals enhanced regulatory effects of human long intergenic non-coding RNAs in lung adenocarcinoma. J Genet Genomics 42(8): 423-436.
    
14. Wei, Q., Lei, R. and Hu, G. (2015). Roles of miR-182 in sensory organ development and cancer. Thorac Cancer 6(1): 2-9.
    
15. Li, X., Chen, X., Hu, G., Liu, Y., Zhang, Z., Wang, P., Zhou, Y., Yi, X., Zhang, J., Zhu, Y., Wei, Z., Yuan, F., Zhao, G., Zhu, J., Hu, L., Kong, X. (2014). Combined analysis with copy number variation identifies risk loci in lung cancer. Biomed Res Int 2014:469103.
    
16. Wan, L., Hu, G., Wei, Y., Yuan, M., Bronson, R. T., Yang, Q., Siddiqui, J., Pienta, K. J. and Kang, Y. (2014). Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 74(18): 5336-5347.
    
17. Lin, B., Wang, Y., Wang, Z., Tan, H., Kong, X., Shu, Y., Zhang, Y., Huang, Y., Zhu, Y., Xu, H., Wang, Z., Wang, P., Ning, G., Kong, X., Hu, G. and Hu, L. (2014). Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort. PLoS One 9(2): e90215.
    
18. Wang, Y., Lei, R., Zhuang, X., Zhang, N., Pan, H., Li, G., Hu, J., Pan, X., Tao, Q., Fu, D., Xiao, J., Chin, Y. E., Kang, Y., Yang, Q. and Hu, G. (2014). DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest 124(4): 1646-1659.
    
19. Zhang, N., Wang, X., Huo, Q., Sun, M., Cai, C., Liu, Z., Hu, G. and Yang, Q. (2014). MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene 33(24): 3119-3128.
    
20. Lei, R., Tang, J., Zhuang, X., Deng, R., Li, G., Yu, J., Liang, Y., Xiao, J., Wang, H. Y., Yang, Q. and Hu, G. (2014). Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis. Oncogene 33(10): 1287-1296.