Education

Ph.D in Biochemistry, Emory University School of Medicine, 1993

Current position

Professor of Pathology, Division of Molecular and Cellular Pathology,
University of Alabama at Birmingham
Director of the BioAnalytical Redox Biology Core, Diabetes Research Center,
Director, NIH Predoctoral Training Program in Cardiovascular Pathophysiology

Publications (since 2006)

1. Fetterman, J. L., Holbrook, M., Westbrook, D. G., Brown, J. A., Feeley, K. P., Breton-Romero, R., Linder, E. A., Berk, B. D., Weisbrod, R. M., Widlansky, M. E., Gokce, N., Ballinger, S. W. and Hamburg, N. M. (2016). Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease. Cardiovasc Diabetol 15: 53.

2. Krzywanski, D. M., Moellering, D. R., Westbrook, D. G., Dunham-Snary, K. J., Brown, J., Bray, A. W., Feeley, K. P., Sammy, M. J., Smith, M. R., Schurr, T. G., Vita, J. A., Ambalavanan, N., Calhoun, D., Dell'Italia, L. and Ballinger, S. W. (2016). Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry. Circ Cardiovasc Genet 9(1): 26-36.

3. Dunham-Snary, K. J. and Ballinger, S. W. (2015). GENETICS. Mitochondrial-nuclear DNA mismatch matters. Science 349(6255): 1449-1450.

4. Feeley, K. P., Bray, A. W., Westbrook, D. G., Johnson, L. W., Kesterson, R. A., Ballinger, S. W. and Welch, D. R. (2015). Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential. Cancer Res 75(20): 4429-4436.

5. Datta, G., Kramer, P. A., Johnson, M. S., Sawada, H., Smythies, L. E., Crossman, D. K., Chacko, B., Ballinger, S. W., Westbrook, D. G., Mayakonda, P., Anantharamaiah, G. M., Darley-Usmar, V. M. and White, C. R. (2015). Bioenergetic programming of macrophages by the apolipoprotein A-I mimetic peptide 4F. Biochem J 467(3): 517-527.

6. Feeley, K. P., Westbrook, D. G., Bray, A. W. and Ballinger, S. W. (2014). An ex-vivo model for evaluating bioenergetics in aortic rings. Redox Biol 2: 1003-1007.

7. Betancourt, A. M., King, A. L., Fetterman, J. L., Millender-Swain, T., Finley, R. D., Oliva, C. R., Crowe, D. R., Ballinger, S. W. and Bailey, S. M. (2014). Mitochondrial-nuclear genome interactions in non-alcoholic fatty liver disease in mice. Biochem J 461(2): 223-232.

8. Chacko, B. K., Kramer, P. A., Ravi, S., Benavides, G. A., Mitchell, T., Dranka, B. P., Ferrick, D., Singal, A. K., Ballinger, S. W., Bailey, S. M., Hardy, R. W., Zhang, J., Zhi, D. and Darley-Usmar, V. M. (2014). The Bioenergetic Health Index: a new concept in mitochondrial translational research. Clin Sci (Lond) 127(6): 367-373.

9. Dunham-Snary, K. J., Sandel, M. W., Westbrook, D. G. and Ballinger, S. W. (2014). A method for assessing mitochondrial bioenergetics in whole white adipose tissues. Redox Biol 2: 656-660.

10. Liu, W., Beck, B. H., Vaidya, K. S., Nash, K. T., Feeley, K. P., Ballinger, S. W., Pounds, K. M., Denning, W. L., Diers, A. R., Landar, A., Dhar, A., Iwakuma, T. and Welch, D. R. (2014). Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. Cancer Res 74(3): 954-963.

11. Allison, D. B., Antoine, L. H., Ballinger, S. W., Bamman, M. M., Biga, P., Darley-Usmar, V. M., Fisher, G., Gohlke, J. M., Halade, G. V., Hartman, J. L., Hunter, G. R., Messina, J. L., Nagy, T. R., Plaisance, E. P., Powell, M. L., Roth, K. A., Sandel, M. W., Schwartz, T. S., Smith, D. L., Sweatt, J. D., Tollefsbol, T. O., Watts, S. A., Yang, Y., Zhang, J. and Austad, S. N. (2014). Aging and energetics' 'Top 40' future research opportunities 2010-2013. F1000Res 3: 219.

12. Dunham-Snary, K. J. and Ballinger, S. W. (2013). Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility. Free Radic Biol Med 65: 1229-1237.

13. Gladden, J. D., Zelickson, B. R., Guichard, J. L., Ahmed, M. I., Yancey, D. M., Ballinger, S., Shanmugam, M., Babu, G. J., Johnson, M. S., Darley-Usmar, V. and Dell'Italia, L. J. (2013). Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload. Am J Physiol Heart Circ Physiol 305(10): H1440-1450.

14. Chacko, B. K., Kramer, P. A., Ravi, S., Johnson, M. S., Hardy, R. W., Ballinger, S. W. and Darley-Usmar, V. M. (2013). Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Lab Invest 93(6): 690-700.

15. Fetterman, J. L., Zelickson, B. R., Johnson, L. W., Moellering, D. R., Westbrook, D. G., Pompilius, M., Sammy, M. J., Johnson, M., Dunham-Snary, K. J., Cao, X., Bradley, W. E., Zhang, J., Wei, C. C., Chacko, B., Schurr, T. G., Kesterson, R. A., Dell'italia, L. J., Darley-Usmar, V. M., Welch, D. R. and Ballinger, S. W. (2013). Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload. Biochem J 455(2): 157-167.

16. Fetterman, J. L., Pompilius, M., Westbrook, D. G., Uyeminami, D., Brown, J., Pinkerton, K. E. and Ballinger, S. W. (2013). Developmental exposure to second-hand smoke increases adult atherogenesis and alters mitochondrial DNA copy number and deletions in apoE(-/-) mice. PLoS One 8(6): e66835.

17. Hill, B. G., Benavides, G. A., Lancaster, J. R., Jr., Ballinger, S., Dell'Italia, L., Jianhua, Z. and Darley-Usmar, V. M. (2012). Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem 393(12): 1485-1512.

18. Krzywanski, D. M., Moellering, D. R., Fetterman, J. L., Dunham-Snary, K. J., Sammy, M. J. and Ballinger, S. W. (2011). The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics. Lab Invest 91(8): 1122-1135.

19. Gladden, J. D., Zelickson, B. R., Wei, C. C., Ulasova, E., Zheng, J., Ahmed, M. I., Chen, Y., Bamman, M., Ballinger, S., Darley-Usmar, V. and Dell'Italia, L. J. (2011). Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload. Free Radic Biol Med 51(11): 1975-1984.

20. Zhai, L., Ballinger, S. W. and Messina, J. L. (2011). Role of reactive oxygen species in injury-induced insulin resistance. Mol Endocrinol 25(3): 492-502.

21. Harrison, C. M., Pompilius, M., Pinkerton, K. E. and Ballinger, S. W. (2011). Mitochondrial oxidative stress significantly influences atherogenic risk and cytokine-induced oxidant production. Environ Health Perspect 119(5): 676-681.

22. Ulasova, E., Gladden, J. D., Chen, Y., Zheng, J., Pat, B., Bradley, W., Powell, P., Zmijewski, J. W., Zelickson, B. R., Ballinger, S. W., Darley-Usmar, V. and Dell'italia, L. J. (2011). Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload. J Mol Cell Cardiol 50(1): 147-156.

23. Westbrook, D. G., Anderson, P. G., Pinkerton, K. E. and Ballinger, S. W. (2010). Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primates. Cardiovasc Toxicol 10(3): 216-226.

24. Chuang, G. C., Yang, Z., Westbrook, D. G., Pompilius, M., Ballinger, C. A., White, C. R., Krzywanski, D. M., Postlethwait, E. M. and Ballinger, S. W. (2009). Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol 297(2): L209-216.

25. Bailey, S. M., Mantena, S. K., Millender-Swain, T., Cakir, Y., Jhala, N. C., Chhieng, D., Pinkerton, K. E. and Ballinger, S. W. (2009). Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE(-/-) mouse: implications for a "multihit" hypothesis of fatty liver disease. Free Radic Biol Med 46(7): 928-938.

26. Cakir, Y., Yang, Z., Knight, C. A., Pompilius, M., Westbrook, D., Bailey, S. M., Pinkerton, K. E. and Ballinger, S. W. (2007). Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis. Free Radic Biol Med 43(9): 1279-1288.

27. Yang, Z., Harrison, C. M., Chuang, G. C. and Ballinger, S. W. (2007). The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosis. Mutat Res 621(1-2): 61-74.

28. Bailey, S. M., Robinson, G., Pinner, A., Chamlee, L., Ulasova, E., Pompilius, M., Page, G. P., Chhieng, D., Jhala, N., Landar, A., Kharbanda, K. K., Ballinger, S. and Darley-Usmar, V. (2006). S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver. Am J Physiol Gastrointest Liver Physiol 291(5): G857-867.

29. Gutierrez, J., Ballinger, S. W., Darley-Usmar, V. M. and Landar, A. (2006). Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ Res 99(9): 924-932.

30. Pan, G., Yang, Z., Ballinger, S. W. and McDonald, J. M. (2006). Pathogenesis of osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDS. Ann N Y Acad Sci 1068: 297-308.

31. Vartanian, V., Lowell, B., Minko, I. G., Wood, T. G., Ceci, J. D., George, S., Ballinger, S. W., Corless, C. L., McCullough, A. K. and Lloyd, R. S. (2006). The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci U S A 103(6): 1864-1869.