Education
Ph.D. in Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA, 2012
Current position
Postdoctoral Associate, Research Laboratory of Electronics and Dept. of Biological Engineering, Massachusetts Institute of Technology (2015-now)
Publications
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Chen, W. C., Lee, B. G., Park, D. W., Kim, K., Chu, H., Kim, K., Huard, J. and Wang, Y. (2015). Controlled dual delivery of fibroblast growth factor-2 and Interleukin-10 by heparin-based coacervate synergistically enhances ischemic heart repair. Biomaterials 72: 138-151.
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Chen, W. C.*, Péault, B. and Huard, J. (2015). Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors. Stem Cells Int 2015: 375187. (*Corresponding author)
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Proto, J. D., Tang, Y.*, Lu, A.*, Chen, W. C.*, Stahl, E., Poddar, M., Beckman, S. A., Robbins, P. D., Nidernhofer, L. J., Imbrogno, K., Hannigan, T., Mars, W. M., Wang, B. and Huard, J. (2015). NF-kappaB inhibition reveals a novel role for HGF during skeletal muscle repair. Cell Death Dis 6: e1730. (*Co-second author)
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Chen, W. C.*, Baily, J. E.*, Corselli, M., Diaz, M. E., Sun, B., Xiang, G., Gray, G. A., Huard, J. and Peault, B. (2015). Human myocardial pericytes: multipotent mesodermal precursors exhibiting cardiac specificity. Stem Cells 33(2): 557-573. (*Co-corresponding author)
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Gao, X., Usas, A., Proto, J. D., Lu, A., Cummins, J. H., Proctor, A., Chen, C. W. and Huard, J. (2014). Role of donor and host cells in muscle-derived stem cell-mediated bone repair: differentiation vs. paracrine effects. FASEB J 28(8): 3792-3809.
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Chen, W. C., Saparov, A., Corselli, M., Crisan, M., Zheng, B., Peault, B. and Huard, J. (2014). Isolation of blood-vessel-derived multipotent precursors from human skeletal muscle. J Vis Exp (90): e51195.
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Beckman, S. A., Sekiya, N.*, Chen, W. C.*, Mlakar, L., Tobita, K. and Huard, J. (2014). The cardiac regenerative potential of myoblasts remains limited despite improving their survival via antioxidant treatment. CellvR4 2(2): e845. (*Co-second author)
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Bodnar, R. J., Rodgers, M. E., Chen, W. C. and Wells, A. (2013). Pericyte regulation of vascular remodeling through the CXC receptor 3. Arterioscler Thromb Vasc Biol 33(12): 2818-2829.
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Saparov, A., Chen, C. W., Beckman, S. A., Wang, Y. and Huard, J. (2013). The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair. Int J Mol Sci 14(8): 16258-16279.
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Chen, W. C., Park, T. S., Murray, I. R., Zimmerlin, L., Lazzari, L., Huard, J. and Peault, B. (2013). Cellular kinetics of perivascular MSC precursors. Stem Cells Int 2013: 983059.
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Li, H., Usas, A., Poddar, M., Chen, C. W., Thompson, S., Ahani, B., Cummins, J., Lavasani, M. and Huard, J. (2013). Platelet-rich plasma promotes the proliferation of human muscle derived progenitor cells and maintains their stemness. PLoS One 8(6): e64923.
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Zheng, B., Li, G., Chen, W. C., Deasy, B. M., Pollett, J. B., Sun, B., Drowley, L., Gharaibeh, B., Usas, A., Peault, B. and Huard, J. (2013). Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level. J Orthop Res 31(7): 1089-1095.
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Gao, X., Usas, A., Lu, A., Tang, Y., Wang, B., Chen, C. W., Li, H., Tebbets, J. C., Cummins, J. H. and Huard, J. (2013). BMP2 is superior to BMP4 for promoting human muscle-derived stem cell-mediated bone regeneration in a critical-sized calvarial defect model. Cell Transplant 22(12): 2393-2408.
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Chen, C. W., Okada, M., Proto, J. D., Gao, X., Sekiya, N., Beckman, S. A., Corselli, M., Crisan, M., Saparov, A., Tobita, K., Peault, B. and Huard, J. (2013). Human pericytes for ischemic heart repair. Stem Cells 31(2): 305-316.
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Chu, H., Chen, C. W., Huard, J. and Wang, Y. (2013). The effect of a heparin-based coacervate of fibroblast growth factor-2 on scarring in the infarcted myocardium. Biomaterials 34(6): 1747-1756.
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Chen, W. C. and Péault, B. (2013). Stem Cells: Development and renewal of ventricular heart muscle from intrinsic progenitor cells. In: Meyers, R. A. (ed). Encyclopedia of Molecular Cell Biology and Molecular Medicine. Wiley-VCH Verlag GmbH & Co., Hoboken.
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Chen, C. W.*, Huard, J. and Péault, B. (2012). Mesenchymal stem cells and cardiovascular repair. In: Xiao, Y. (ed). Mesenchymal Stem Cells. Nova Science: 363-378. (*Corresponding author)
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Gerlach, J. C., Over, P., Turner, M. E., Thompson, R. L., Foka, H. G., Chen, W. C., Peault, B., Gridelli, B. and Schmelzer, E. (2012). Perivascular mesenchymal progenitors in human fetal and adult liver. Stem Cells Dev 21(18): 3258-3269.
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Crisan, M., Corselli, M.*, Chen, W. C.* and Peault, B. (2012). Perivascular cells for regenerative medicine. J Cell Mol Med 16(12): 2851-2860. (*Co-second author)
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Chen, C. W.*, Corselli, M., Peault, B. and Huard, J. (2012). Human blood-vessel-derived stem cells for tissue repair and regeneration. J Biomed Biotechnol 2012: 597439. (*Corresponding author)
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Zheng, B.*, Chen, C. W.*, Li, G., Thompson, S. D., Poddar, M., Peault, B. and Huard, J. (2012). Isolation of myogenic stem cells from cultures of cryopreserved human skeletal muscle. Cell Transplant 21(6): 1087-1093. (*Co-first author)
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Corselli, M., Chen, C. W., Sun, B., Yap, S., Rubin, J. P. and Peault, B. (2012). The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells. Stem Cells Dev 21(8): 1299-1308.
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Okada, M., Payne, T. R., Drowley, L., Jankowski, R. J., Momoi, N., Beckman, S., Chen, W. C., Keller, B. B., Tobita, K. and Huard, J. (2012). Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts. Mol Ther 20(1): 138-145.
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Chu, H., Gao, J.*, Chen, C. W.*, Huard, J. and Wang, Y. (2011). Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis. Proc Natl Acad Sci U S A 108(33): 13444-13449. (*Co-second author)
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Crisan, M., Corselli, M., Chen, C. W. and Peault, B. (2011). Multilineage stem cells in the adult: a perivascular legacy? Organogenesis 7(2): 101-104.
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Xiang, G., Yang, Q., Wang, B., Sekiya, N., Mu, X., Tang, Y., Chen, C. W., Okada, M., Cummins, J., Gharaibeh, B. and Huard, J. (2011). Lentivirus-mediated Wnt11 gene transfer enhances Cardiomyogenic differentiation of skeletal muscle-derived stem cells. Mol Ther 19(4): 790-796.
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Park, T. S., Gavina, M.*, Chen, C. W.*, Sun, B., Teng, P. N., Huard, J., Deasy, B. M., Zimmerlin, L. and Peault, B. (2011). Placental perivascular cells for human muscle regeneration. Stem Cells Dev 20(3): 451-463. (*Co-second author)
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Lin, C. H., Hsu, S. H., Su, J. M. and Chen, C. W. (2011). Surface modification of poly(epsilon-caprolactone) porous scaffolds using gelatin hydrogel as the tracheal replacement. J Tissue Eng Regen Med 5(2): 156-162.
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Corselli, M., Chen, C. W., Crisan, M., Lazzari, L. and Peault, B. (2010). Perivascular ancestors of adult multipotent stem cells. Arterioscler Thromb Vasc Biol 30(6): 1104-1109.
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Chen, C. W., Montelatici, E., Crisan, M., Corselli, M., Huard, J., Lazzari, L. and Peault, B. (2009). Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both? Cytokine Growth Factor Rev 20(5-6): 429-434.
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Crisan, M., Chen, C. W., Corselli, M., Andriolo, G., Lazzari, L. and Peault, B. (2009). Perivascular multipotent progenitor cells in human organs. Ann N Y Acad Sci 1176: 118-123.
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Crisan, M., Yap, S., Casteilla, L., Chen, C. W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., Norotte, C., Teng, P. N., Traas, J., Schugar, R., Deasy, B. M., Badylak, S., Buhring, H. J., Giacobino, J. P., Lazzari, L., Huard, J. and Peault, B. (2008). A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3(3): 301-313.
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Liu, C., Chen, C. W. and Ducheyne, P. (2008). In vitro surface reaction layer formation and dissolution of calcium phosphate cement-bioactive glass composites. Biomed Mater 3(3): 034111.
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Liu, C., Chen, C. W. and Ducheyne, P. (2007). Effects of the composition of the bioactive composite calcium phosphate cement on its behavior in the solution. In: Key Engineering Materials. Trans Tech Publications: 823-826.