Education
Ph.D. in Virology, Department of Microbiology and Molecular Genetics, Harvard University, 1996
Current position
Associate Professor of Medicine and Microbiology/Immunology
Director of Hepatology Research
Basic Science Director, Clinical Research Office
Co-Director, Program of Experimental and Theoretical Modeling, Loyola University Medical Center
Maywood, IL, USA
Publications (since 2009)
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Uprichard, S. L. and Sainz, B. (2014). Inhibition of hepatitis C entry: too soon to dismiss while many are still being denied treatment. Gut. (Epub ahead of print)
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Sabahi, A., Uprichard, S. L., Wimley, W. C., Dash, S. and Garry, R. F. (2014). Unexpected structural features of the hepatitis C virus envelope protein 2 ectodomain. J Virol 88(18): 10280-10288.
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Barretto, N., Sainz, B., Jr., Hussain, S. and Uprichard, S. L. (2014). Determining the involvement and therapeutic implications of host cellular factors in hepatitis C virus cell-to-cell spread. J Virol 88(9): 5050-5061.
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Uprichard, S. L. (2014). Establishment of mice with inheritable susceptibility to productive hepatitis C virus infection. Hepatology 59(5): 2043-2046.
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Lee, H., Zhu, T., Patel, K., Zhang, Y. Y., Truong, L., Hevener, K. E., Gatuz, J. L., Subramanya, G., Jeong, H. Y., Uprichard, S. L. and Johnson, M. E. (2013). High-throughput screening (HTS) and hit validation to identify small molecule inhibitors with activity against NS3/4A proteases from multiple hepatitis C virus genotypes. PLoS One 8(10): e75144.
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Guedj, J., Dahari, H., Uprichard, S. L. and Perelson, A. S. (2013). The hepatitis C virus NS5A inhibitor daclatasvir has a dual mode of action and leads to a new virus half-life estimate. Expert Rev Gastroenterol Hepatol 7(5): 397-399.
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Martin, D. N. and Uprichard, S. L. (2013). Identification of transferrin receptor 1 as a hepatitis C virus entry factor. Proc Natl Acad Sci U S A 110(26): 10777-10782.
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Guedj, J., Dahari, H., Rong, L., Sansone, N. D., Nettles, R. E., Cotler, S. J., Layden, T. J., Uprichard, S. L. and Perelson, A. S. (2013). Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proc Natl Acad Sci U S A 110(10): 3991-3996.
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Yu, X., Sainz, B., Jr., Petukhov, P. A. and Uprichard, S. L. (2012). Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay. Antimicrob Agents Chemother 56(12): 6109-6120.
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Hussain, S., Barretto, N. and Uprichard, S. L. (2012). New hepatitis C virus drug discovery strategies and model systems. Expert Opin Drug Discov 7(9): 849-859.
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Sainz, B., Jr., Barretto, N., Yu, X., Corcoran, P. and Uprichard, S. L. (2012). Permissiveness of human hepatoma cell lines for HCV infection. Virol J 9: 30.
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Sainz, B., Jr., Barretto, N., Martin, D. N., Hiraga, N., Imamura, M., Hussain, S., Marsh, K. A., Yu, X., Chayama, K., Alrefai, W. A. and Uprichard, S. L. (2012). Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med 18(2): 281-285.
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Tencate, V., Sainz, B., Jr., Cotler, S. J. and Uprichard, S. L. (2010). Potential treatment options and future research to increase hepatitis C virus treatment response rate. Hepat Med 2010(2): 125-145.
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Uprichard, S. L. (2010). Hepatitis C virus experimental model systems and antiviral drug research. Virol Sin 25(4): 227-245.
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Yu, X. and Uprichard, S. L. (2010). Cell-based hepatitis C virus infection fluorescence resonance energy transfer (FRET) assay for antiviral compound screening. Curr Protoc Microbiol Chapter 17: Unit 17 15.
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Sabahi, A., Marsh, K. A., Dahari, H., Corcoran, P., Lamora, J. M., Yu, X., Garry, R. F. and Uprichard, S. L. (2010). The rate of hepatitis C virus infection initiation in vitro is directly related to particle density. Virology 407(1): 110-119.
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Cobleigh, M. A., Buonocore, L., Uprichard, S. L., Rose, J. K. and Robek, M. D. (2010). A vesicular stomatitis virus-based hepatitis B virus vaccine vector provides protection against challenge in a single dose. J Virol 84(15): 7513-7522.
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Sainz, B., Jr., Barretto, N. and Uprichard, S. L. (2009). Hepatitis C virus infection in phenotypically distinct Huh7 cell lines. PLoS One 4(8): e6561.
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Yu, X., Sainz, B., Jr. and Uprichard, S. L. (2009). Development of a cell-based hepatitis C virus infection fluorescent resonance energy transfer assay for high-throughput antiviral compound screening. Antimicrob Agents Chemother 53(10): 4311-4319.
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Sainz, B., Jr., TenCate, V. and Uprichard, S. L. (2009). Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection. Virol J 6: 103.
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Li, L., Oropeza, C. E., Sainz, B., Jr., Uprichard, S. L., Gonzalez, F. J. and McLachlan, A. (2009). Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. PLoS One 4(5): e5489.
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Dahari, H., Sainz, B., Jr., Perelson, A. S. and Uprichard, S. L. (2009). Modeling subgenomic hepatitis C virus RNA kinetics during treatment with alpha interferon. J Virol 83(13): 6383-6390.
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Choi, S., Sainz, B., Jr., Corcoran, P., Uprichard, S. and Jeong, H. (2009). Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells. Xenobiotica 39(3): 205-217.