Education

Ph.D. in Neurobiology, Columbia University, 1984

Current position

Full Professor, Faculty of Life Sciences, Bar-Ilan University (2011-present)

Publications

Articles (since 2009)

1. Sloutskin, A., Yee, M. B., Kinchington, P. R. and Goldstein, R. S. (2014). Varicella-zoster virus and herpes simplex virus 1 can infect and replicate in the same neurons whether co- or superinfected. J Virol 88(9): 5079-5086.
   
2. Markus, A., Waldman Ben-Asher, H., Kinchington, P. R. and Goldstein, R. S. (2014). Cellular transcriptome analysis reveals differential expression of pro- and antiapoptosis genes by varicella-zoster virus-infected neurons and fibroblasts. J Virol 88(13): 7674-7677.
   
3. Sloutskin, A. and Goldstein, R. S. (2014). Laboratory preparation of Varicella-Zoster Virus: concentration of virus-containing supernatant, use of a debris fraction and magnetofection for consistent cell-free VZV infections. J Virol Methods 206: 128-132.
   
4. Sloutskin, A. and Goldstein, R. S. (2014). Infectious focus assays and multiplicity of infection (MOI) calculations for alpha-herpesviruses. Bio-protocol 4(22): e1295.
   
5. Birenboim, R., Markus, A. and Goldstein, R. S. (2013). Simple generation of neurons from human embryonic stem cells using agarose multiwell dishes. J Neurosci Methods 214(1): 9-14.
   
6. Pode-Shakked, N., Shukrun, R., Mark-Danieli, M., Tsvetkov, P., Bahar, S., Pri-Chen, S., Goldstein, R. S., Rom-Gross, E., Mor, Y., Fridman, E., Meir, K., Simon, A., Magister, M., Kaminski, N., Goldmacher, V. S., Harari-Steinberg, O. and Dekel, B. (2013). The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets. EMBO Mol Med 5(1): 18-37.
   
7. Sloutskin, A., Kinchington, P. R. and Goldstein, R. S. (2013). Productive vs non-productive infection by cell-free varicella zoster virus of human neurons derived from embryonic stem cells is dependent upon infectious viral dose. Virology 443(2): 285-293.
   
8. Harari-Steinberg, O., Metsuyanim, S., Omer, D., Gnatek, Y., Gershon, R., Pri-Chen, S., Ozdemir, D. D., Lerenthal, Y., Noiman, T., Ben-Hur, H., Vaknin, Z., Schneider, D. F., Aronow, B. J., Goldstein, R. S., Hohenstein, P. and Dekel, B. (2013). Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease. EMBO Mol Med 5(10): 1556-1568.
   
9. Buzhor, E., Omer, D., Harari-Steinberg, O., Dotan, Z., Vax, E., Pri-Chen, S., Metsuyanim, S., Pleniceanu, O., Goldstein, R. S. and Dekel, B. (2013). Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties. Am J Pathol 183(5): 1621-1633.
   
10. Dukhovny, A., Sloutskin, A., Markus, A., Yee, M. B., Kinchington, P. R. and Goldstein, R. S. (2012). Varicella-zoster virus infects human embryonic stem cell-derived neurons and neurospheres but not pluripotent embryonic stem cells or early progenitors. J Virol 86(6): 3211-3218.
    
11. Grinberg, I., Dukhovny, A. and Goldstein, R. S. (2012). A rapid and simple assay for human blood malignancy engraftment, homing and chemotherapy treatment using fluorescent imaging of avian embryos. Leuk Lymphoma 53(3): 472-478.
    
12. Goldenberg-Cohen, N., Avraham-Lubin, B. C., Sadikov, T., Goldstein, R. S. and Askenasy, N. (2012). Primitive stem cells derived from bone marrow express glial and neuronal markers and support revascularization in injured retina exposed to ischemic and mechanical damage. Stem Cells Dev 21(9): 1488-1500.
    
13. Selariu, A., Cheng, T., Tang, Q., Silver, B., Yang, L., Liu, C., Ye, X., Markus, A., Goldstein, R. S., Cruz-Cosme, R. S., Lin, Y., Wen, L., Qian, H., Han, J., Dulal, K., Huang, Y., Li, Y., Xia, N. and Zhu, H. (2012). ORF7 of varicella-zoster virus is a neurotropic factor. J Virol 86(16): 8614-8624.
    
14. Grigoryan, S., Kinchington, P. R., Yang, I. H., Selariu, A., Zhu, H., Yee, M. and Goldstein, R. S. (2012). Retrograde axonal transport of VZV: kinetic studies in hESC-derived neurons. J Neurovirol 18(6): 462-470.
    
15. Pode-Shakked, N., Harari-Steinberg, O., Haberman-Ziv, Y., Rom-Gross, E., Bahar, S., Omer, D., Metsuyanim, S., Buzhor, E., Jacob-Hirsch, J., Goldstein, R. S., Mark-Danieli, M. and Dekel, B. (2011). Resistance or sensitivity of Wilms' tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target. Oncogene 30(14): 1664-1680.
    
16. Ziegler, L., Grigoryan, S., Yang, I. H., Thakor, N. V. and Goldstein, R. S. (2011). Efficient generation of Schwann cells from human embryonic stem cell-derived neurospheres. Stem Cell Reviews and Reports 7(2): 394-403.
    
17. Markus, A., Grigoryan, S., Sloutskin, A., Yee, M. B., Zhu, H., Yang, I. H., Thakor, N. V., Sarid, R., Kinchington, P. R. and Goldstein, R. S. (2011). Varicella-zoster virus (VZV) infection of neurons derived from human embryonic stem cells: direct demonstration of axonal infection, transport of VZV, and productive neuronal infection. J Virol 85(13): 6220-6233.
    
18. Kahana, S., Finniss, S., Cazacu, S., Xiang, C., Lee, H. K., Brodie, S., Goldstein, R. S., Roitman, V., Slavin, S., Mikkelsen, T. and Brodie, C. (2011). Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCepsilon-dependent downregulation of AKT and XIAP expressions. Cell Signal 23(8): 1348-1357.
    
19. Noiman, T., Buzhor, E., Metsuyanim, S., Harari-Steinberg, O., Morgenshtern, C., Dekel, B. and Goldstein, R. S. (2011). A rapid in vivo assay system for analyzing the organogenetic capacity of human kidney cells. Organogenesis 7(2): 140-144.
    
20. Buzhor, E., Harari-Steinberg, O., Omer, D., Metsuyanim, S., Jacob-Hirsch, J., Noiman, T., Dotan, Z., Goldstein, R. S. and Dekel, B. (2011). Kidney spheroids recapitulate tubular organoids leading to enhanced tubulogenic potency of human kidney-derived cells. Tissue Eng Part A 17(17-18): 2305-2319.
    
21. Farnoushi, Y., Cipok, M., Kay, S., Jan, H., Ohana, A., Naparstek, E., Goldstein, R. S. and Deutsch, V. R. (2011). Rapid in vivo testing of drug response in multiple myeloma made possible by xenograft to turkey embryos. Br J Cancer 105(11): 1708-1718.
    
22. Goldstein, R. S. (2010). The chick embryo as an accessible model for study of hESC differentiation. Meth Mol Biol 584:367-385. (Book chapter, Springer/Humana Press)
    
23. Goldstein, R. S., Pomp, O., Brokhman, I, and Siegler, L. (2010). Generating peripheral sensory neurons and their neural crest precursors from human hESC. Meth Mol Biol 584:283-300. (Book chapter, Springer/Humana Press)
    
24. Ziegler, L., Segal-Ruder, Y., Coppola, G., Reis, A., Geschwind, D., Fainzilber, M. and Goldstein, R. S. (2010). A human neuron injury model for molecular studies of axonal regeneration. Exp Neurol 223(1): 119-127.
    
25. Goldstein, R. S. (2010). Transplantation of mammalian embryonic stem cells and their derivatives to avian embryos. Stem Cell Rev 6(3): 473-483.
    
26. Lerer-Goldshtein, T., Bel, S., Shpungin, S., Pery, E., Motro, B., Goldstein, R. S., Bar-Sheshet, S. I., Breitbart, H. and Nir, U. (2010). TMF/ARA160: A key regulator of sperm development. Dev Biol 348(1): 12-21.
    
27. Brokhman, I., Pomp, O., Fishman, L., Tennenbaum, T., Amit, M., Itzkovitz-Eldor, J. and Goldstein, R. S. (2009). Genetic modification of human embryonic stem cells with adenoviral vectors: differences of infectability between lines and correlation of infectability with expression of the coxsackie and adenovirus receptor. Stem Cells Dev 18(3): 447-456.
    
28. Slodownik, D., Grinberg, I., Spira, R. M., Skornik, Y. and Goldstein, R. S. (2009). The human skin/chick chorioallantoic membrane model accurately predicts the potency of cosmetic allergens. Exp Dermatol 18(4): 409-413.
    
29. Grinberg, I., Reis, A., Ohana, A., Taizi, M., Cipok, M., Tavor, S., Rund, D., Deutsch, V. R. and Goldstein, R. S. (2009). Engraftment of human blood malignancies to the turkey embryo: a robust new in vivo model. Leuk Res 33(10): 1417-1426.
    
30. Ganor, Y., Grinberg, I., Reis, A., Cooper, I., Goldstein, R. S. and Levite, M. (2009). Human T-leukemia and T-lymphoma express glutamate receptor AMPA GluR3, and the neurotransmitter glutamate elevates the cancer-related matrix-metalloproteinases inducer CD147/EMMPRIN, MMP-9 secretion and engraftment of T-leukemia in vivo. Leuk Lymphoma 50(6): 985-997.