Education
M.D. in Hematology, Shanghai Second Military Medical University, China, 1991
Current position
Assistant Professor, Department of Medicine/Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina
Publications (selected from 39 papers)
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An, N., Janech, M., Bland, A., Lazarchick, J., Arthur, J. and Kang, Y. (2013). Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution. Exp Hematol.
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An, N., Lin, Y. W., Mahajan, S., Kellner, J. N., Wang, Y., Li, Z., Kraft, A. S. and Kang, Y. (2013). Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells. Stem Cells 31(6): 1202-1212.
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An, N., Kraft, A. S. and Kang, Y. (2013). Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice. J Hematol Oncol 6: 12.
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An, N. and Kang, Y. (2013). Using quantitative real-time PCR to determine donor cell engraftment in a competitive murine bone marrow transplantation model. J Vis Exp(73): e50193.
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Costa, L. J.*, Kramer, C., Hogan, K. R., Butcher, C. D., Littleton, A. L., Shoptaw, K. B., Kang, Y.* and Stuart, R. K. (2012). Pegfilgrastim‐versus filgrastim‐based autologous hematopoietic stem cell mobilization in the setting of preemptive use of plerixafor: efficacy and cost analysis. Transfusion 52(11): 2375-2381. *Co-first authorship
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Costa, L. J., Abbas, J., Hogan, K. R., Kramer, C., McDonald, K., Butcher, C. D., Littleton, A., Shoptaw, K., Kang, Y. and Stuart, R. K. (2012). Growth factor plus preemptive ('just-in-time') plerixafor successfully mobilizes hematopoietic stem cells in multiple myeloma patients despite prior lenalidomide exposure. Bone Marrow Transplant 47(11): 1403-1408.
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Butler, C., Wolff, D. J., Kang, Y., Stuart, R. K. and Costa, L. J. (2012). Association of age with fluorescence in situ hybridization abnormalities in multiple myeloma reveals higher rate of IGH translocations among older patients. Leuk Lymphoma 53(12): 2444-2448.
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Zhou, D., Deoliveira, D., Kang, Y., Choi, S. S., Li, Z., Chao, N. J. and Chen, B. J. (2013). Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation. Int J Radiat Oncol Biol Phys 85(4): 1141-1148.
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Costa, L. J., Abbas, J., Ortiz-Cruz, K. L., Kang, Y. and Stuart, R. K. (2012). Outcomes of patients with multiple myeloma and renal impairment treated with bortezomib, cyclophosphamide, and dexamethasone without plasma exchange. Eur J Haematol 89(5): 432-434.
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Kang, Y., Chen, B. J., Deoliveira, D., Mito, J. and Chao, N. J. (2010). Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model. PLoS One 5(6): e11316.
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Kang, Y., Moressi, C. J., Scheetz, T. E., Xie, L., Tran, D. T., Casavant, T. L., Ak, P., Benham, C. J., Davidson, B. L. and McCray, P. B., Jr. (2006). Integration site choice of a feline immunodeficiency virus vector. J Virol 80(17): 8820-8823.
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Kang, Y., Xie, L., Tran, D. T., Stein, C. S., Hickey, M., Davidson, B. L. and McCray, P. B., Jr. (2005). Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer. Blood 106(5): 1552-1558.
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Kang, Y.*, Stein, C. S.*, Heth, J. A., Sinn, P. L., Penisten, A. K., Staber, P. D., Ratliff, K. L., Shen, H., Barker, C. K., Martins, I., Sharkey, C. M., Sanders, D. A., McCray, P. B., Jr. and Davidson, B. L. (2002). In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins. J Virol 76(18): 9378-9388. *Co-first authorship
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Melo, M. E., Qian, J., El-Amine, M., Agarwal, R. K., Soukhareva, N., Kang, Y. and Scott, D. W. (2002). Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases. J Immunol 168(9): 4788-4795.
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Stein, C. S.*, Kang, Y.*, Sauter, S. L., Townsend, K., Staber, P., Derksen, T. A., Martins, I., Qian, J., Davidson, B. L. and McCray, P. B., Jr. (2001). In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors. Mol Ther 3(6): 850-856. *Co-first authorship
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El-Amine, M., Melo, M., Kang, Y., Nguyen, H., Qian, J. and Scott, D. W. (2000). Mechanisms of tolerance induction by a gene-transferred peptide-IgG fusion protein expressed in B lineage cells. J Immunol 165(10): 5631-5636.
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Agarwal, R. K., Kang, Y., Zambidis, E., Scott, D. W., Chan, C. C. and Caspi, R. R. (2000). Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J Clin Invest 106(2): 245-252. (Commentary by George C. Tsoko and Gerald T. Nepom, “Gene therapy in the treatment of autoimmune diseases”, J. Clin. Invest. 106:181-183).
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Kang, Y., Melo, M., Deng, E., Tisch, R., El-Amine, M. and Scott, D. W. (1999). Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: the IgG scaffold is important for induction and maintenance of immune hyporesponsiveness. Proc Natl Acad Sci U S A 96(15): 8609-8614.
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Kang, Y., Melo, E. F. and Scott, D. W. (1998). An ongoing immune response to HIV envelope gp120 in human CD4-transgenic mice contributes to T cell decline upon intravenous administration of gp120. Eur J Immunol 28(8): 2253-2264.