Kaustabh Ghosh Department of Bioengineering, Program in Cell, Molecular and Developmental Biology, University of California, USA
1 protocol
Francesco Dal Grande Senckenberg Gesellschaft fuer Naturforschung
3 protocols

Giusy Tornillo Cardiff University
15 protocols

Jia Li SRI International
51 protocols

Ralph Boettcher Max Planck Institute for Biochemistry
47 protocols

Irit Adini
  • Harvard Medical School
Research focus
  • Molecular biology
  • 1 Author merit


Ph.D. in Microbiology and Molecular Genetics, Hebrew University Hadassah Medical School, Jerusalem, Israel, 2002

Current position

Visiting Project Scientist, Department of Bioengineering, University of California, Riverside


*Corresponding author

  1. Adini, I.*, Adini, A., Bazinet, L., Watnick, R. S., Bielenberg, D. R. and D'Amato, R. J. (2015). Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB J 29(2): 662-670.
  2. Panigrahy, D., Adini, I., Mamluk, R., Levonyak, N., Bruns, C. J., D'Amore, P. A., Klagsbrun, M. and Bielenberg, D. R. (2014). Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration. Pathology 46(5): 416-423.
  3. Adini, I.*, Ghosh, K., Adini, A., Chi, Z. L., Yoshimura, T., Benny, O., Connor, K. M., Rogers, M. S., Bazinet, L., Birsner, A. E., Bielenberg, D. R. and D'Amato, R. J. (2014). Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest 124(1): 425-436.
  4. Kontos, C. D. (2014). More than skin deep: connecting melanocyte pigmentation and angiogenic diseases. J Clin Invest 124(1): 76-79. 
  5. Adini, A., Adini, I., Ghosh, K., Benny, O., Pravda, E., Hu, R., Luyindula, D. and D'Amato, R. J. (2013). The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action. Angiogenesis 16(2): 405-416.
  6. Gerald, D., Adini, I., Shechter, S., Perruzzi, C., Varnau, J., Hopkins, B., Pravda, E., Kurschat, P., Klagsbrun, M., Prendergast, G. C., Stuhlmann, H., Rigby, A. C., Nagy, J. A. and L. E. (2013). Benjamin nuclear RhoB-VEZF1 complex regulates the differential response of blood versus lymphatic endothelium to stress. Nat Commun 4:2824.
  7. Rogers, M. S., Adini, I., McBride, A. F., Birsner, A. E. and D'Amato, R. J. (2013). The albino mutation of tyrosinase alters ocular angiogenic responsiveness. Angiogenesis 16(3): 639-646. 
  8. Spivey, K. A., Chung, I., Banyard, J., Adini, I., Feldman, H. A. and Zetter, B. R. (2012). A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis. Oncogene 31(18): 2362-2372.
  9. Greenberger, S., Adini, I., Boscolo, E., Mulliken, J. B. and Bischoff, J. (2010). Targeting NF-kappaB in infantile hemangioma-derived stem cells reduces VEGF-A expression. Angiogenesis 13(4): 327-335. 
  10. Greenberger, S., Boscolo, E., Adini, I., Mulliken, J. B. and Bischoff, J. (2010). Corticosteroid suppression of VEGF-A in infantile hemangioma-derived stem cells. N Engl J Med 362(11): 1005-1013.
  11. Sun, J., Hopkins, B. D., Tsujikawa, K., Perruzzi, C., Adini, I., Swerlick, R., Bornstein, P., Lawler, J. and Benjamin, L. E. (2009). Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina. Am J Physiol Heart Circ Physiol 296(5): H1344-1351. 
  12. Fainaru, O.*, Adini, I.*, Benny, O., Bazinet, L., Pravda, E., D'Amato, R. and Folkman, J. (2008). Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J 22(10): 3728-3735.
  13. Benny, O., Fainaru, O., Adini, A., Cassiola, F., Bazinet, L., Adini, I., Pravda, E., Nahmias, Y., Koirala, S., Corfas, G., D'Amato, R. J. and Folkman, J. (2008). An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nat Biotechnol 26(7): 799-807.
  14. Fainaru, O., Adini, A., Benny, O., Adini, I., Short, S., Bazinet, L., Nakai, K., Pravda, E., Hornstein, M. D., D'Amato, R. J. and Folkman, J. (2008). Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis. FASEB J 22(2): 522-529.
  15. Pakneshan, P., Birsner, A. E., Adini, I., Becker, C. M. and D’Amato, R. J. (2008). Suppression of vascular permeability and corneal angiogenesis by non-steroidal anti-inflammatory drugs. Investigative Opthalmology and Visual Sciences 49(9): 3909-13.
  16. Adini, I., Ephros, M., Chen, J. and Jaffe, C. L. (2003). Asymptomatic visceral leishmaniasis, northern Israel. Emerg Infect Dis 9(3): 397-398.
  17. Adini, I., Rabinovitz, I., Sun, J. F., Prendergast, G. C. and Benjamin, L. E. (2003). RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev 17(21): 2721-2732.
  18. Baneth, G., Dank, G., Keren-Kornblatt, E., Sekeles, E., Adini, I., Eisenberger, C. L., Schnur, L. F., King, R. and Jaffe, C. L. (1998). Emergence of visceral leishmaniasis in central Israel. Am J Trop Med Hyg 59(5): 722-725.
  19. Adini, I., Jacobson, R. L., Kasap, M., Schlein, Y. and Jaffe, C. L. (1998). Species-specific detection of Leishmania in sandflies using an enzyme-linked immunosorbent assay. Trans R Soc Trop Med Hyg 92(1): 35-37.
1 Protocol published
Mouse Retinal Whole Mounts and Quantification of Vasculature Protocol
Authors:  Irit Adini and Kaustabh Ghosh, date: 08/05/2015, view: 12388, Q&A: 1
Angiogenesis is the formation of new blood vessels from a pre-existing vascular bed. It is a multi-step process beginning with enzymatic degradation of the capillary basement membrane, followed by endothelial cell (EC) proliferation, migration, tube ...
4 Protocols reviewed
Mouse Embryonic Tooth Germ Dissection and Ex vivo Culture Protocol
Authors:  Xue Han, Keigo Yoshizaki, Tian Tian, Kanako Miyazaki, Ichiro Takahashi and Satoshi Fukumoto, date: 02/05/2020, view: 1621, Q&A: 1
A tooth germ ex vivo organ culture allows visualization of its development in different stages, thus enabling investigation of the molecular mechanisms of regulatory factors. Tooth germs can be rapidly dissected from E13 mouse embryos and ...
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Ex vivo Trophoblast-specific Genetic Manipulation Using Lentiviral Delivery
Authors:  Damayanti Chakraborty, Masanaga Muto and Michael J. Soares, date: 12/20/2017, view: 4316, Q&A: 0
In this protocol report, we describe a lentiviral gene delivery technique for genetic modification of the rat trophoblast cell lineage. Lentiviral packaged gene constructs can be efficiently and specifically delivered to the trophoblast cell lineage ...
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