Michael Kammüller Novartis Institutes for Biomedical Research Basel
1 protocol

Ainhoa Arbués Swiss Tropical and Public Health Institute Basel
1 protocol

Damien Portevin
  • Group leader, Medical Parasitology and Infection Biology Swiss Tropical and Public Health Institute
Research focus
  • Immunology
  • 1 Author merit

Education

PhD, 2005

Publications

1. TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like Mycobacterium tuberculosis.
Arbués A, Brees D, Chibout SD, Fox T, Kammüller M, Portevin D. PLoS Pathog. 2020 Feb 18;16(2):e1008312. doi: 10.1371/journal.ppat.1008312. eCollection 2020 Feb. PMID: 32069329
2.HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses.
Amelio P, Portevin D, Hella J, Reither K, Kamwela L, Lweno O, Tumbo A, Geoffrey L, Ohmiti K, Ding S, Pantaleo G, Daubenberger C, Perreau M. J Virol. 2019 Feb 19;93(5):e01728-18. doi: 10.1128/JVI.01728-18. Print 2019 Mar 1. PMID: 30541853
3. The Candidate Blood-stage Malaria Vaccine P27A Induces a Robust Humoral Response in a Fast Track to the Field Phase 1 Trial in Exposed and Nonexposed Volunteers.
Steiner-Monard V, Kamaka K, Karoui O, Roethlisberger S, Audran R, Daubenberger C, Fayet-Mello A, Erdmann-Voisin A, Felger I, Geiger K, Govender L, Houard S, Huber E, Mayor C, Mkindi C, Portevin D, Rusch S, Schmidlin S, Tiendrebeogo RW, Theisen M, Thierry AC, Vallotton L, Corradin G, Leroy O, Abdulla S, Shekalaghe S, Genton B, Spertini F, Jongo SA. Clin Infect Dis. 2019 Jan 18;68(3):466-474. doi: 10.1093/cid/ciy514. PMID: 29945169 Clinical Trial.
4. Hyperglycaemia is inversely correlated with live M. bovis BCG-specific CD4+ T cell responses in Tanzanian adults with latent or active tuberculosis.
Boillat-Blanco N, Tumbo AN, Perreau M, Amelio P, Ramaiya KL, Mganga M, Schindler C, Gagneux S, Reither K, Probst-Hensch N, Pantaleo G, Daubenberger C, Portevin D. Immun Inflamm Dis. 2018 Jun;6(2):345-353. doi: 10.1002/iid3.222. Epub 2018 Apr 11. PMID: 29642283
5. Functional characterization and phenotypic monitoring of human hematopoietic stem cell expansion and differentiation of monocytes and macrophages by whole-cell mass spectrometry.
Vogel G, Cuénod A, Mouchet R, Strauss A, Daubenberger C, Pflüger V, Portevin D. Stem Cell Res. 2018 Jan;26:47-54. doi: 10.1016/j.scr.2017.11.013. Epub 2017 Nov 22. PMID: 29227832
6. Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania.
Amelio P, Portevin D, Reither K, Mhimbira F, Mpina M, Tumbo A, Nickel B, Marti H, Knopp S, Ding S, Penn-Nicholson A, Darboe F, Ohmiti K, Scriba TJ, Pantaleo G, Daubenberger C, Perreau M. PLoS Negl Trop Dis. 2017 Jul 31;11(7):e0005817. doi: 10.1371/journal.pntd.0005817. eCollection 2017 Jul. PMID: 28759590
7. Maturation and Mip-1β Production of Cytomegalovirus-Specific T Cell Responses in Tanzanian Children, Adolescents and Adults: Impact by HIV and Mycobacterium tuberculosis Co-Infections.
Portevin D, Moukambi F, Mpina M, Bauer A, Haraka F, Chachage M, Metzger P, Saathoff E, Clowes P, Ntinginya NE, Rachow A, Hoelscher M, Reither K, Daubenberger CA, Geldmacher C. PLoS One. 2015 May 14;10(5):e0126716. doi: 10.1371/journal.pone.0126716. eCollection 2015. PMID: 25974183
8. Quantitative whole-cell MALDI-TOF MS fingerprints distinguishes human monocyte sub-populations activated by distinct microbial ligands.
Portevin D, Pflüger V, Otieno P, Brunisholz R, Vogel G, Daubenberger C. BMC Biotechnol. 2015 Apr 11;15:24. doi: 10.1186/s12896-015-0140-1. PMID: 25887592
9. Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis.
Portevin D, Sukumar S, Coscolla M, Shui G, Li B, Guan XL, Bendt AK, Young D, Gagneux S, Wenk MR. Microbiologyopen. 2014 Dec;3(6):823-35. doi: 10.1002/mbo3.193. Epub 2014 Sep 19. PMID: 25238051
10. Assessment of the novel T-cell activation marker-tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study.
Portevin D, Moukambi F, Clowes P, Bauer A, Chachage M, Ntinginya NE, Mfinanga E, Said K, Haraka F, Rachow A, Saathoff E, Mpina M, Jugheli L, Lwilla F, Marais BJ, Hoelscher M, Daubenberger C, Reither K, Geldmacher C. Lancet Infect Dis. 2014 Oct;14(10):931-8. doi: 10.1016/S1473-3099(14)70884-9. Epub 2014 Aug 31. PMID: 25185458
11. Natural killer cell cytokine response to M. bovis BCG Is associated with inhibited proliferation, increased apoptosis and ultimate depletion of NKp44(+)CD56(bright) cells.
Portevin D, Young D. PLoS One. 2013 Jul 15;8(7):e68864. doi: 10.1371/journal.pone.0068864. Print 2013. PMID: 23874793
12. Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus).
Via LE, Weiner DM, Schimel D, Lin PL, Dayao E, Tankersley SL, Cai Y, Coleman MT, Tomko J, Paripati P, Orandle M, Kastenmayer RJ, Tartakovsky M, Rosenthal A, Portevin D, Eum SY, Lahouar S, Gagneux S, Young DB, Flynn JL, Barry CE 3rd. Infect Immun. 2013 Aug;81(8):2909-19. doi: 10.1128/IAI.00632-13. Epub 2013 May 28. PMID: 23716617
13. Natural killer cells are recruited during pulmonary tuberculosis and their ex vivo responses to mycobacteria vary between healthy human donors in association with KIR haplotype.
Portevin D, Via LE, Eum S, Young D. Cell Microbiol. 2012 Nov;14(11):1734-44. doi: 10.1111/j.1462-5822.2012.01834.x. Epub 2012 Jul 30. PMID: 22788220
14. Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages.
Portevin D, Gagneux S, Comas I, Young D. PLoS Pathog. 2011 Mar;7(3):e1001307. doi: 10.1371/journal.ppat.1001307. Epub 2011 Mar 3. PMID: 21408618
15. Identification of a stress-induced factor of Corynebacterineae that is involved in the regulation of the outer membrane lipid composition.
Meniche X, Labarre C, de Sousa-d'Auria C, Huc E, Laval F, Tropis M, Bayan N, Portevin D, Guilhot C, Daffé M, Houssin C. J Bacteriol. 2009 Dec;191(23):7323-32. doi: 10.1128/JB.01042-09. Epub 2009 Oct 2. PMID: 19801408
16. Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy.
Portevin D, Poupot M, Rolland O, Turrin CO, Fournié JJ, Majoral JP, Caminade AM, Poupot R. J Transl Med. 2009 Sep 24;7:82. doi: 10.1186/1479-5876-7-82. PMID: 19778420
17. The use of temperature-sensitive plasmids in mycobacteria.
Portevin D, Malaga W, Guilhot C. Methods Mol Biol. 2009;465:229-42. doi: 10.1007/978-1-59745-207-6_15. PMID: 20560074
18. The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components.
Portevin D, de Sousa-D'Auria C, Montrozier H, Houssin C, Stella A, Lanéelle MA, Bardou F, Guilhot C, Daffé M. J Biol Chem. 2005 Mar 11;280(10):8862-74. doi: 10.1074/jbc.M408578200. Epub 2005 Jan 4. PMID: 15632194
19. A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms.
Portevin D, De Sousa-D'Auria C, Houssin C, Grimaldi C, Chami M, Daffé M, Guilhot C. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):314-9. doi: 10.1073/pnas.0305439101. Epub 2003 Dec 26. PMID: 14695899
1 Protocol published
Generating Three-dimensional Human Granulomas in vitro to Study Mycobacterium tuberculosis-host Interaction
Authors:  Ainhoa Arbués, Michael Kammüller and Damien Portevin, date: 11/20/2020, view: 507, Q&A: 0
Granulomas are organized multicellular structures that constitute the hallmark of an infection by the human pathogen Mycobacterium tuberculosis (Mtb). A better understanding of the complex host-Mtb interactions within the ...
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