Nobumoto Watanabe Bio-Active Compounds Discovery Research Unit, RIKEN CSRS, Saitama, 351-0198
2 protocols

Hiroyuki Osada 2 protocols

Yasumitsu Kondoh 2 protocols

Makoto Muroi 2 protocols

Kruthi Suvarna
  • Post-Doctoral Fellow, Department of bioscience and bioengineering, Indian institute of technology, Bombay, 2019-
Research focus
  • -
  • 2 Author merit

Education

Ph.D in Life Science, Tokyo Medical and Dental University (RIKEN, IPA), Japan, 2017

Publications

• Suvarna, K., Honda, K., Muroi, M., Kondoh, Y., Osada, H. and Watanabe, N. (2019). A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration. J Biol Chem 294(9): 2988-2996.
• Suvarna, K., Honda, K., Kondoh, Y., Osada, H. and Watanabe, N. (2018). Identification of a small-molecule ligand of beta-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells. Cancer Med 7(3): 883-893.
2 Protocols published
Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry
Development of methods for protein identification is one of the important aspects of proteomics. Here, we report a protocol for the preparation of compound conjugated beads by photo-crosslinking, affinity purification, gel electrophoresis, and ...
Measurement of ATPase Activity of Valosin-containing Protein/p97
Valosin-containing protein (VCP; also known as p97) is a type II ATPase regulating several cellular processes. Using proteomic techniques, we identified a chemical compound that binds to the D1 ATPase domain of VCP. The protocol described here was ...
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