Haixia Xu
  • Basic Life Research Scientist, stanford university
Research focus
  • Cell biology
  • macrophage polarization, hypoglycemia; islet beta cell proliferation


PhD, Sun Yat-sen University, 2011

Lab information

Justin Annes


1: Xian Y, Xu H (co-first author), Gao Y, Yan J, Lv J, Ren W, Huang Q, Jiang Z, Xu F, Yao B, WengJ. A pilot study of preproinsulin peptides reactivity in Chinese patients with type 1 diabetes. Diabetes Metab Res Rev. 2020 Feb;36(2):e3228. doi:10.1002/dmrr.3228. Epub 2019 Nov 10. PMID: 31655017; PMCID: PMC7027544.
2: Zhu M, Xu K, Chen Y, Gu Y, Zhang M, Luo F, Liu Y, Gu W, Hu J, Xu H, Xie Z,Sun C, Li Y, Sun M, Xu X, Hsu HT, Chen H, Fu Q, Shi Y, Xu J, Ji L, Liu J, BianL, Zhu J, Chen S, Xiao L, Li X, Jiang H, Shen M, Huang Q, Fang C, Li X, Huang G,Fan J, Jiang Z, Jiang Y, Dai J, Ma H, Zheng S, Cai Y, Dai H, Zheng X, Zhou H, NiS, Jin G, She JX, Yu L, Polychronakos C, Hu Z, Zhou Z, Weng J, Shen H, Yang T. Identification of Novel T1D Risk Loci and Their Association With Age and Islet Function at Diagnosis in Autoantibody-Positive T1D Individuals: Based on a Two-Stage Genome-Wide Association Study. Diabetes Care. 2019 Aug;42(8):1414-1421.doi: 10.2337/dc18-2023. Epub 2019 May 31. PMID: 31152121.
3: Pan X, Shao Y, Wu F, Wang Y, Xiong R, Zheng J, Tian H, Wang B, Wang Y, ZhangY, Han Z, Qu A, Xu H, Lu A, Yang T, Li X, Xu A, Du J, Lin Z. FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. Cell Metab. 2018 Jun 5;27(6):1323-1337.e5.doi: 10.1016/j.cmet.2018.04.002. Epub 2018 Apr 26. PMID: 29706566.
4: Zeng W, Tang J, Li H, Xu H, Lu H, Peng H, Lin C, Gao R, Lin S, Lin K, Liu K,Jiang Y, Weng J, Zeng L. Caveolin-1 deficiency protects pancreatic β cells against palmitate-induced dysfunction and apoptosis. Cell Signal. 2018Jul;47:65-78. doi: 10.1016/j.cellsig.2018.03.013. Epub 2018 Mar 26. PMID:29596872.
5: Abdolazimi Y, Zhao Z, Lee S, Xu H, Allegretti P, Horton TM, Yeh B, Moeller HP, Nichols RJ, McCutcheon D, Shalizi A, Smith M, Armstrong NA, Annes JP. CC-401Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition. Endocrinology. 2018 Sep 1;159(9):3143-3157. doi: 10.1210/en.2018-00083. PMID:29514186; PMCID: PMC6287593.
6: Li H, Peng H, Xu H, Xu F, Lin S, Lin K, Zeng W, Zeng L. The effects ofcaveolin1 on β cell proliferation. Cell Mol Biol (Noisy-le-grand). 2018 Jan31;64(1):40-46. doi: 10.14715/cmb/2018.64.1.8. PMID: 29412792.
7: Liu L, Yan J, Xu H, Zhu Y, Liang H, Pan W, Yao B, Han X, Ye J, Weng J. TwoNovel MicroRNA Biomarkers Related to β-Cell Damage and Their Potential Valuesfor Early Diagnosis of Type 1 Diabetes. J Clin Endocrinol Metab. 2018 Apr1;103(4):1320-1329. doi: 10.1210/jc.2017-01417. PMID: 29370422.
8: Navarro G, Abdolazami Y, Zhao Z, Xu H, Lee S, Armstrong NA, Annes JP. Erratum. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes2017;66:1928-1938. Diabetes. 2017 Dec;66(12):3145. doi: 10.2337/db17-er12f. Epub2017 Oct 10. Erratum for: Diabetes. 2017 Jul;66(7):1928-1938. corrected to Abdolazimi. PMID: 29017999; PMCID: PMC5697949.
9: Xu F, Lin B, Zheng X, Chen Z, Cao H, Xu H, Liang H, Weng J. GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1.Diabetologia. 2016 May;59(5):1059-69. doi: 10.1007/s00125-016-3896-5. Epub 2016Feb 29. PMID: 26924394.
10: Zhang E, Xu F, Liang H, Yan J, Xu H, Li Z, Wen X, Weng J. GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice. Am J Reprod Immunol. 2015Nov;74(5):457-66. doi: 10.1111/aji.12420. Epub 2015 Aug 19. PMID: 26287267.
11: Li R, Xu W, Luo S, Xu H, Tong G, Zeng L, Zhu D, Weng J. Effect of exenatide, insulin and pioglitazone on bone metabolism in patients with newly diagnosed type 2 diabetes. Acta Diabetol. 2015 Dec;52(6):1083-91. doi:10.1007/s00592-015-0792-2. Epub 2015 Aug 7. PMID: 26249206.
12: Xu F, Li Z, Zheng X, Liu H, Liang H, Xu H, Chen Z, Zeng K, Weng J. SIRT1mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis. Diabetes. 2014 Nov;63(11):3637-46. doi: 10.2337/db14-0263. Epub 2014Jun 19. PMID: 24947350.
13: Xu HX, Xu W, Xu F, Liang H, Yan JH, Chen ZP, Sun YT, Yao B, Weng JP.[Association of TNF-1031T/C and clinical efficacy of insulin therapy in newlydiagnosed type 2 diabetics]. Zhonghua Yi Xue Za Zhi. 2013 Oct29;93(40):3197-201. Chinese. PMID: 24405540.
14: Liu X, Xu H(co-first author), Zheng Z, Wang C, Cheng C, Shi C, Gong Y, Li M, Lou T.Estimating glomerular filtration rates in elderly Chinese patients with chronic kidney disease: performance of six modified formulae developed in Asian populations. Clin Interv Aging. 2013;8:899-904. doi: 10.2147/CIA.S47009. Epub2013 Jul 15. PMID: 23901265; PMCID: PMC3720580.
15: Lin S, Hu L, Li X, Chen Y, Xu H, He S, Ren Z, Tang X, Qiu Y, Xu J, Mu P,Zeng L. Glycated haemoglobin A₁c for diagnosing diabetes in Chinese subjects over 50 years old: a community-based cross-sectional study. Clin Endocrinol(Oxf). 2014 May;80(5):656-61. doi: 10.1111/cen.12202. Epub 2013 Apr 9. PMID:23488681.
16: Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, ShiC, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, Hu X. Notch-RBP-Jsignaling regulates the transcription factor IRF8 to promote inflammatorymacrophage polarization. Nat Immunol. 2012 May 20;13(7):642-50. doi:10.1038/ni.2304. PMID: 22610140; PMCID: PMC3513378.
17: Foldi J, Chung AY, Xu H, Zhu J, Outtz HH, Kitajewski J, Li Y, Hu X, IvashkivLB. Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. J Immunol. 2010 Nov 1;185(9):5023-31. doi:10.4049/jimmunol.1001544. Epub 2010 Sep 24. PMID: 20870935; PMCID: PMC3010732.
18: Huang J, Li C, Xu H, Gu J. Novel non-HLA-susceptible regions determined bymeta-analysis of four genomewide scans for ankylosing spondylitis. J Genet. 2008Apr;87(1):75-81. doi: 10.1007/s12041-008-0010-x. PMID: 18560177.
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