Hisashi Shirakawa
  • Post-doctoral Researcher, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2005-2006,
    Assistant Professor, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2006-2014;
    Associate Professor, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2014-2019
Research focus
  • Neuroscience
  • 1 Author merit

Education

Ph.D., Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2005

Publications

Selected
• Andoh, C., Nishitani, N., Hashimoto, E., Nagai, Y., Takao, K., Miyakawa, T., Nakagawa, T., Mori, Y., Nagayasu, K., Shirakawa, H. and Kaneko, S. (2019). TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Res 1704: 68-77.
• Kakae, M., Miyanohara, J., Morishima, M., Nagayasu, K., Mori, Y., Shirakawa, H. and Kaneko, S. (2019). Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice. Neuroscience 408: 204-213.
• Kakae, M., Tobori, S., Morishima, M., Nagayasu, K., Shirakawa, H. and Kaneko, S. (2019). Depletion of microglia ameliorates white matter injury and cognitive impairment in a mouse chronic cerebral hypoperfusion model. Biochem Biophys Res Commun 514(4): 1040-1044.
• Nishitani, N., Nagayasu, K., Asaoka, N., Yamashiro, M., Andoh, C., Nagai, Y., Kinoshita, H., Kawai, H., Shibui, N., Liu, B., Hewinson, J., Shirakawa, H., Nakagawa, T., Hashimoto, H., Kasparov, S. and Kaneko, S. (2019). Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats. Neuropsychopharmacology 44(4): 721-732.
• Nishitani, N., Nagayasu, K., Asaoka, N., Yamashiro, M., Andoh, C., Nagai, Y., Kinoshita, H., Kawai, H., Shibui, N., Liu, B., Hewinson, J., Shirakawa, H., Nakagawa, T., Hashimoto, H., Kasparov, S. and Kaneko, S. (2019). Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats. Neuropsychopharmacology 44(4): 721-732.
• Shirakawa, H. and Kaneko, S. (2018). Physiological and Pathophysiological Roles of Transient Receptor Potential Channels in Microglia-Related CNS Inflammatory Diseases. Biol Pharm Bull 41(8): 1152-1157.
• Miyanohara, J., Kakae, M., Nagayasu, K., Nakagawa, T., Mori, Y., Arai, K., Shirakawa, H. and Kaneko, S. (2018). TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion. J Neurosci 38(14): 3520-3533.
• Kaneko, S. (2018). TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion. J Neurosci 38(14): 3520-3533.
• Tsutsui, M., Hirase, R., Miyamura, S., Nagayasu, K., Nakagawa, T., Mori, Y., Shirakawa, H. and Kaneko, S. (2018). TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines. J Neurosci 38(39): 8484-8495.
• Temma, T., Yamazaki, M., Miyanohara, J., Shirakawa, H., Kondo, N., Koshino, K., Kaneko, S. and Iida, H. (2017). Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of (15)O-gas in mice with bilateral common carotid artery stenosis. J Cereb Blood Flow Metab 37(10): 3334-3343.
• Miyake, T., Nakamura, S., Zhao, M., So, K., Inoue, K., Numata, T., Takahashi, N., Shirakawa, H., Mori, Y., Nakagawa, T. and Kaneko, S. (2016). Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat Commun 7: 12840.
• So, K., Tei, Y., Zhao, M., Miyake, T., Hiyama, H., Shirakawa, H., Imai, S., Mori, Y., Nakagawa, T., Matsubara, K. and Kaneko, S. (2016). Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice. Sci Rep 6: 23261. Miyanohara, J., Kakae, M., Nagayasu, K., Nakagawa, T., Mori, Y., Arai, K., Shirakawa, H. and
• Miyake, T., Shirakawa, H., Nakagawa, T. and Kaneko, S. (2015). Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration. Glia 63(10): 1870-1882.
• Munakata, M., Shirakawa, H., Nagayasu, K., Miyanohara, J., Miyake, T., Nakagawa, T., Katsuki, H. and Kaneko, S. (2013). Transient receptor potential canonical 3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice. Stroke 44(7): 1981-1987.
• Konno, M., Shirakawa, H., Iida, S., Sakimoto, S., Matsutani, I., Miyake, T., Kageyama, K., Nakagawa, T., Shibasaki, K. and Kaneko, S. (2012). Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide. Glia 60(5): 761-770.
1 Protocol published
Myelin Oligodendrocyte Glycoprotein 35-55 (MOG 35-55)-induced Experimental Autoimmune Encephalomyelitis: A Model of Chronic Multiple Sclerosis
Authors:  Sakie Miyamura, Nagisa Matsuo, Kazuki Nagayasu, Hisashi Shirakawa and Shuji Kaneko, date: 12/20/2019, view: 2015, Q&A: 0
Multiple sclerosis (MS) is the common demyelinating disease of human central nervous system. Among mouse models available to study MS, including the cuprizone application and lysolecithin-injection models, experimental autoimmune encephalomyelitis ...
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.