Giacomo Garibotto Clinica Nefrologica, Dialisi, Trapianto , Università and Ospedale S.Martino, Italy, Italy,
1 protocol

Francesca Costigliolo Clinica Nefrologica, Dialisi, Trapianto , Università and Ospedale S.Martino, Italy, Italy,
1 protocol

Daniela Verzola Clinica Nefrologica, Dialisi, Trapianto , Università and Ospedale S.Martino, Italy, Italy,
1 protocol

Samantha Milanesi
  • Clinica Nefrologica, Dialisi, Trapianto , Università and Ospedale S.Martino, Italy, Italy,
  • 1 Author merit

Education

Ph.D. Program in Clinical-Experimental Internal Medicine, University of Genoa, Italy, 2012

Current position

Post-Doc. Position, Immunology, Humanitas Research Hospital, Italy

Publications

  1. M. Gregorini, V. Corradetti, C. Rocca, E.F. Pattonieri, T. Valsania, S. Milanesi, N. Serpieri, G. Bedino, P. Esposito, C. Libetta, M.A. Avanzini, M. Mantelli, D. Ingo, S. Peressini, R. Albertini, A. Dal Canton, T. Rampino. Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR. PLOS ONE February 11, 2016. doi:10.1371/journal.pone.0148542

  2. F. Ansaldo, D. Picciotto, F. Viazzi, S. Milanesi, G. Garibotto and D. Verzola. Myostatin Structure, role in the muscle development and health implication. Chapter2: Myostatin and the balance between positive and negative regulators of muscle mass in patients with chronic kidney disease. 2016 Nova Science Publishers, Inc. ISBN: 978-1-63485-230-2.

  3. D. Verzola, F. Ansaldo, S. Milanesi, E.L. Parodi, G.M. Rosa, A. Sofia, A. Bonanni, F. Viazzi, M. Balbia, G. Garibotto. Inter-organ handling of Fibroblast Growth Factor-23 in humans. Am J Physiol Renal Physiol. 2017 Feb 1;312(2):F254-F258. Epub 2016 Aug 24. doi:10.1152/ajprenal.00396.2016

  4. D. Verzola, S. Milanesi, M. Bertolotto, S. Garibaldi, B. Villaggio, C. Brunelli, M. Balbi, P. Ameri, D. Palombo, G. Ghigliotti, J. Lindeman and C. Barisione. Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment. Sci Rep. 2017 Apr 13;7:46362. doi: 10.1038/srep46362.

  5. P. Esposito, E. La Porta, M. Calatroni, M.A. Grignano, S. Milanesi, D. Verzola, Y. Battaglia, M. Gregorini, C. Libetta, G. Garibotto and T. Rampino. Modulation of Myostatin/Epatocyte Growth Factor balance by different hemodialysis modalities. Biomed Res Int. 2017;2017:7635459. Epub 2017 Mar 28. doi: 10.1155/2017/7635459.

  6. M. Gregorini, V. Corradetti, E.F. Pattonieri, C. Rocca, S. Milanesi, A. Peloso, S. Canevari, L. De Cecco, M. Matteo, M.A. Avanzini, M. Mantelli, M. Maestri, P. Esposito, S. Bruno, C. Libetta, A. Dal Canton, T. Rampino. Perfusion of isolated rat kidney with Mesenchymal Stromal Cell/Extracellular Vesicles prevents ischemic injury by preserving energy machinery. J Cell Mol Med. 2017 Jun 21. doi: 10.1111/jcmm.13249.

  7. P. Esposito, E. La Porta, M. A. Grignano, D. Verzola, S. Milanesi, F. Ansaldo, M. Gregorini, C. Libetta, G. Garibotto, T. Rampino. Soluble Toll-like Receptor 4: A New Player in Subclinical Inflammation and Malnutrition in Hemodialysis Patients. Journal of Renal Nutrition. 18 Feb 08. doi:https://doi.org/10.1053/j.jrn.2017.11.006.

  8. S. Milanesi, D. Verzola, F. Cappadona, B. Bonino, A. Murugavel, R. Pontremoli, G. Garibotto, F. Viazzi. Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll‐like receptor 4. J Cell Physiol. 2018;1–9. doi: 10.1002/jcp.27929.

    Abstracts:

  1. L. Ferrari, A. Pistocchi, L. Libera, S. Milanesi, N. Boari, P. Mortini, F. Cotelli and P. Riva. Dysregulation of FAS and FASL in Chordoma: study in zebrafish animal model. XV National Congress SIGU. November 1-24, 2012, Sorrento, Italy.

  2. S. Milanesi, C. Rocca, M. Gregorini, V. Corradetti, E. F. Pattonieri, M. Cannone, N. Maggi, F. Bosio, P. Esposito, C. Bianco, I. Benzoni, M. Maestri, M. A. Avanzini, T. Rampino, A. Dal Canton. Mesenchymal stromal cells downregulate renin-angiotensin system in unilateral ureteral obstruction model in rats suppressing HuR. ERA-EDTA Congress 31 May- 3 June 2014 Amsterdam, Netherlands.

  3. V. Corradetti, S. Milanesi, C. Rocca, M. A. Avanzini, E. F. Pattonieri, F. Bosio, M. Cannone, N. Maggi, M. Gregorini, P. Esposito, T. Rampino, A. Dal Canton. Mesenchymal stromal cells suppress in vitro renin mRNA trascription in macrophages and epithelial cells. ERA-EDTA Congress 31 May-3 June 2014 Amsterdam, Netherlands.

  4. E. F. Pattonieri, M. Gregorini, V. Corradetti, C. Rocca, S. Milanesi, A. Peloso, J. Ferrario, M. Cannone, F. Bosio, N. Maggi, M. A. Avanzini, P. Minutillo, M. Paulli, M. Maestri, T. Rampino, A. Dal Canton. Pre-trasplant graft reconditioning with mesenchymal stromal cells in non heart beating donor experimental model. ERA-EDTA Congress 31 May- 3 June 2014 Amsterdam, , Netherlands.

  5. V. Corradetti, S. Milanesi, E.F. Pattonieri, C. Rocca, T. Valsania, M. Gregorini, L. De Cecco, I. Benzoni, C. Bianco, M.A. Avanzini, M, Maestri, P. Esposito, T. Rampino & A. Dal Canton. Pre- transplant perfusion with mesenchymal stromal cells of renal graft prevents ischemiainjury upregulating gene involved in energy saving. American Transplant Congress (ATC) 2-6 May 2015, Philadeplhia, USA.

  6. M. Bertolotto, S. Milanesi, D. Palombo, G. Garibotto, B. Villaggio, J.H. Lindeman, G. Ghigliotti, C. Brunelli, P. Ameri, D. Verzola& C. Barisione. Myostatin: a playmaker in atherosclerosisand AAA progression? Annual Scientific Meeting of the European Society for Clinical Investigation ESCI 27- 30 May 2015, Cluj-Napoca, Romania.

  7. P. Esposito, E. La Porta, S. Milanesi, M. Calatroni, C. Martinelli, I. Borettaz, M. Canevari, D. Verzola, T. Rampino, C. Libetta, G. Garibotto& A. Dal Canton. Effects of dialysismodality on myostatin/ HGF balance regular HD patients. ERA-EDTA Congress 28-31 May 2015, London, UK.

  8. C. Rocca, S. Milanesi, V. Corradetti, E.F. Pattonieri, T. Valsania, M. Gregorini, M. Dugo, L.De Cecco, I. Benzoni, C. Bianco, M.A. Avanzini, M. Mantelli, D. Ingo, M. Maestri, M. Cannone, P. Esposito, T. Rampino e A. Dal Canton. Pre-conditioning of renal graft withmesenchymal stromal cells prevents ischemia damage upregulating gene involved in energy saving. ERA-EDTA Congress 2015, 28-31 May 2015 London UK.

  9. E. La Porta, P. Esposito, M. Calatroni , C. Martinelli, E. Caramella , S. Milanesi, D. Verzola, C. Libetta, G. Garibotto, A. Dal Canton. Variazioni del equilibrio Myostatin/HGF sierico nelle diverse metodiche emodialitiche: una nuova strategia terapeutica per la wasting syndrome? 56º Congresso Nazionale Società italiana di Nefrologia (SIN) 1-4 October 2015, Rimini, Italy.

  10. C. Rocca, S. Milanesi, V. Corradetti, E.F. Pattonieri, M. Gregorini, M. Dugo, L. De Cecco, S. Canevari, I. Benzoni, C. Bianco, M.A. Avanzini , M. Mantelli, D. Ingo, M. Maestri, P. Esposito, T. Rampino, A. Dal Canton. Pre-conditioning of renal graft with mesenchymalstromal cells prevents ischemia damage upregulating gene involved in energy saving. 56º Congresso Nazionale Società italiana di Nefrologia (SIN) 1-4 October 2015, Rimini, Italy.

  11. E.F. Pattonieri, V. Corradetti, S. Milanesi, T. Valsania , C. Rocca, S. Romeo, M. Gregorini, P. Esposito, S. Peressini, M.A. Avanzini, A. Peloso, M. Maestri, T. Rampino, A. Dal Canton. Il condizionamento del rene con cellule mesenchimali stromali e microvescicole preserva l’organo dal danno ischemico in un modello di trapianto di rene a cuore non battente. 56º Congresso Nazionale Società italiana di Nefrologia (SIN) 1-4 October 2015, Rimini, Italy.

  12. G. Garibotto, M. Bertolotto, S. Milanesi, D. Palombo, B. Villaggio, J.H. Lindeman, G. Ghigliotti, C .Brunelli, P. Ameri, D. Verzola, C. Barisione. Myostatin: a playmaker in chronic kidney disease and vascular damage. American Society of Nephrology (ASN) 3-8 November, 2015, San Diego, USA.

  13. S. Milanesi , D. Verzola , M. Bertolotto , S. Garibaldi , D. Palombo, G. Garibotto, B. Villaggio,
    P. Ameri , G. Ghigliotti , C. Brunelli, J.H. Lindeman, C. Barisione. Miostatina: un nuovo mediatore precoce del rimodellamento aterosclerotico dell’aorta addominale. Forum SIRC 18 June 2016 Genoa, Italy.

  14. E La Porta, P Esposito, D Verzola, S Milanesi, M A Grignano, A dal Canton, G Garibotto. Myostatin: a new player in uremic vascular remodeling and fibrosis in uremia. Forum SIRC 18 June 2016, Genoa, Italy.

  15. C. Barisione, D.Verzola, S. Garibaldi, P. Altieri, S. Milanesi, G. Ghigliotti, C. Brunelli, G. Garibotto, P. Ameri. Valsartan counteracts cardiac fibroblast activation and myostatin expression induced by indoxyl sulfate. Forum SIRC 18 June 2016, Genoa, Italy.

  16. F. Viazzi, D. Verzola, S. Milanesi, B. Bonino, F. Cappadona, E. Parodi, A. Murugavel, R. Pontremoli, G. Garibotto. Il danno delle cellule tubulo prossimale associato all’acido urico è mediato dal sistema immunitario innato tramite il TLR4. 57º Congresso Nazionale Società italiana di Nefrologia (SIN) 12-15 October 2016, Milan, Italy.

  17. G. Garibotto, D. Verzola, S. Milanesi, F. Ansaldo, F. Viazzi, A. Carta, D. Picciotto, F. Costigliolo, C. Barisione. Myostatin, a new mediator of inflammation and tissue injury in diabetic nephropathy. America Society of Nephrology (ASN) 15-20 November 2016, Chicago, USA

  18. E. La Porta, P. Esposito, D. Verzola, S. Milanesi, A. Dal Canton, G. Garibotto. Myostatin: a new player in uremic vascular remodeling and fibrosis in uremia. America Society of Nephrology (ASN) 15-20 November 2016, Chicago, USA.

  19. G. Garibotto, D. Verzola, F. Ansaldo, S. Milanesi, F. Viazzi. The Kidney is the major for fibroblast growth factor-23 disposal in humans. America Society of Nephrology (ASN) 15-20 November 2016, Chicago, USA

  20. F. Viazzi, D. Verzola, S. Milanesi, F. Ansaldo, F. Viazzi, A. Carta, D. Picciotto, F. Costigliolo,
    G. Garibotto. TLR4 Links Uric Acid with the Innate Immune System to Mediate Injury in Proximal Tubule Cells. America Society of Nephrology (ASN) 15-20 November 2016, Chicago, USA.

  21. D. Verzola, F. Ansaldo, S. Milanesi, E.L. Parodi, G.M. Rosa, A. Sofia, A. Bonanni, F. Viazzi, M. Balbi and G. Garibotto. The kidney is the major site for the regulation of soluble Klotho in humans. ERA-EDTA Congress 3-6 June 2017, Madrid, Spain.

  22. P. Esposito E. La Porta M. Calatroni M.A. Grignano E. Caramella, A. Avella, S. Milanesi, D. Verzola, F. Ansaldo Y. Battaglia M. Gregorini, C. Libetta, G. Garibotto, T, Rampino. Soluble TLR4in hemodialysis patients. ERA-EDTA Congress 3-6 June 2017, Madrid, Spain.

  23. S. Milanesi, D. Verzola, , F. Ansaldo, F. Viazzi, A. Carta, D. Picciotto, F. Costigliolo, G. Garibotto. Myostatin not only a myokine: a new possible actor in diabetic nephropathy. Oral communication at the plenary section at Annual Scientific Meeting of the European Society for Clinical Investigation ESCI Congress 17-19 May 2017, Genoa, Italy.

  24. S. Milanesi, F. Ansaldo, M. Saio, C. Barisione, B. Villaggio, D. Picciotto, D. Verzola, G. Garibotto. Diabetic milieu induces Myostatin in Renal proximal tubular cell line. Annual Scientific Meeting of the European Society for Clinical Investigation ESCI Congress 17-19 May 2017, Genoa, Italy.

  25. D. Verzola, S. Milanesi, C. Barisione, S. Garibaldi, M. Saio , A. Murugavel, A. Carta, D. Picciotto, F. Costigliolo, F. Viazzi, G. Garibotto. Heat Shock Protein 90 contribuisce ai processi di fibrosi e infiammazione indotti dall’ Indossilsolfato nei fibroblasti renali. 58º Congresso Nazionale Società italiana di Nefrologia (SIN) 4-7 October 2017, Rimini, Italy.

  26. D. Verzola, F. Ansaldo, S. Milanesi, E. L. Parodi, G. Rosa, A. Sofia, A. Bonanni, F. Viazzi, M. Balbi, G. Garibotto. The kidney is the major site for the regulation of soluble Klotho in humans. America Society of Nephrology (ASN) 31 Oct- 5 Nov. 2017, New Orleans, LA. USA.

  27. S Milanesi, D Verzola, C Barisione, S Garibaldi, M Saio, D Picciotto, A Murugavel, F Costigliolo, E Gianetta, G Brunori, C Venturelli, G Garibotto. Activation of the NLRP3 Inflammasome promotes Inflammation in skeletal muscle of patients with CKD. Oral Presentation at ERA EDTA 24-27 May 2018, Copenhagen, Denmark.

  28. S Milanesi, M Saio, D Picciotto, E Gianetta, G Brunori, C Venturelli, G Garibotto, D Verzola. The regulation of adiponectin and its receptor in skeletal muscle and visceral fat in patients with CKD: a role in maintaining the anti-inflammatory homeostasis. ERA EDTA 24-27 May 2018, Copenhagen, Denmark.

  29. Saio, D Verzola, S Milanesi, C Barisione, S Garibaldi, A Carta, D Picciotto, F Costigliolo, F. Viazzi, G Garibotto. Indoxyl Sulfate induces fibrosis and inflammation by upregulating Heat Shock protein 90 (HSP 90) in renal fibroblasts. ERA EDTA 24-27 May 2018, Copenhagen, Denmark.

  30. D Picciotto, S Milanesi, M Saio, M Frascio, G Brunori, C Venturelli, G Garibotto, D Verzola. Wasting in patients with CKD and diabetes: the role of Myostatin. ERA EDTA 24-27 May 2018, Copenhagen, Denmark.

  31. P Esposito, E La Porta, D Verzola, MA Grignano, S Milanesi, M Calatroni, E Caramella, A Avella, M Abelli, E Ticozzelli, T Rampino, G Garibotto. Myostatin: a new player in the complexity of uremic vasculopathy. ERA EDTA 24-27 May 2018, Copenhagen, Denmark.

  32. S Milanesi, D Verzola, C Barisione, S Garibaldi, M Saio, D Picciotto, A Murugavel, F Costigliolo, E Gianetta, G Brunori, C Venturelli, G Garibotto. The NLRP3 Inflammasome is activated in skeletal muscle of patients with CKD5. ORAL SESSION: PROTEIN METABOLISM, INTRACELLULAR SIGNALING at 19th Congress of the International Society of Renal Nutrition and Metabolism (ICRNM) 26-30 June 2018, Genova, Italy

  33. S Milanesi, M Saio, D Picciotto, E Gianetta, G Brunori, C Venturelli, G Garibotto, D Verzola. Adiponectin and its receptor regulation in skeletal muscle and visceral fat in patients with CKD. 19th Congress of the International Society of Renal Nutrition and Metabolism (ICRNM) 26-30 June 2018, Genova, Italy.

  34. Saio, D Verzola, S Milanesi, C Barisione, S Garibaldi, A Carta, D Picciotto, F Costigliolo, F. Viazzi, G Garibotto. Indoxyl Sulfate induces fibrosis and inflammation by upregulating Heat Shock protein 90 (HSP 90) in renal fibroblasts. Oral presentation at 19th Congress of the International Society of Renal Nutrition and Metabolism (ICRNM) 26-30 June 2018, Genova, Italy.

  35. D Picciotto, S Milanesi, M Saio, M Frascio, G Brunori, C Venturelli, G Garibotto, D Verzola. Blunted Intracellular Insulin Signaling plus High Myostatin Cooperate to Induce Wasting in  Patients with Diabetic Kidney Disease. 19th Congress of the International Society of Renal Nutrition and Metabolism (ICRNM) 26-30 June 2018, Genova, Italy.

  36. F Cappadona, F Viazzi, D Verzola, S Milanesi, B Bonino, E L. Parodi, A Murugavel, R Pontremoli, G Garibotto. Uric acid and angiotensin II additively promote innate immunity and inflammation in human renal tubular cells. 19th Congress of the International Society of Renal Nutrition and Metabolism (ICRNM) 26-30 June 2018, Genova, Italy.

  37. D Picciotto, D Verzola, C Barisione, F Costigliolo, A Sofia, M Saio, G Garibotto, L Poggi, S Milanesi. Myostatin: a new mediator of fibrosis in diabetic nephropathy? 19th Congress of the International Society of Renal Nutrition and Metabolism (ICRNM) 26-30 June 2018, Genova, Italy.

  38. P Esposito, E La Porta, D Verzola, S Milanesi, M A Grignano, M Abelli, T Rampino, G Garibotto. Increasing The Complexity Of Uremic Vasculopathy: A Role For Myostatin. 19th Congress of the International Society of of Renal Nutrition and Metabolism (ICRNM) 26-30 June 2018, Genova, Italy.

1 Protocol published
Immunohistochemical Staining of TLR4 in Human Skeletal Muscle Samples
Authors:  Daniela Verzola, Samantha Milanesi, Francesca Costigliolo and Giacomo Garibotto, date: 01/20/2019, view: 1008, Q&A: 0
Growing evidence suggests the involvement of TLR4, a receptor in the innate immune system, in muscle loss in uremia. Recently, we have evaluated TLR4 in human skeletal muscle from chronic kidney disease patients, by immunohistochemistry and image ...
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