Holden Maecker Human Immune Monitoring Center (HIMC), Institute for Immunity, Transplantation and Infection, Department of Microbiology & Immunology, Stanford University, USA
8 protocols

Molly Miranda 1 protocol

Miao Zhao 1 protocol

Igor Goncharov 1 protocol

Xuhuai Ji
  • Human Immune Monitoring Center (HIMC), Institute for Immunity, Transplantation and Infection, Department of Microbiology & Immunology, Stanford University, USA, USA,
  • 1 Author merit
Lab Protocol Hub

Education

Certified MD, Educational Commission for Foreign Medical Graduates (ECFMG), USA, 2007

Current position

Sr. Staff Scientist & Genomics Manager, Human Immune Monitoring Center (HIMC), Institute for Immunology, Transplantation and Infection (ITI), Stanford University, USA

Publications

  1. Alpert A, Pickman A, Leipold M, Rosenberg-Hasson Y, Ji X, Gaujoux R, Rabani H, Starosvetsky E, Kveler K, Schaffert S, Furman D, Caspi O, Rosenschein U, Khatri P, Dekker CL, Maecker HM, Davis DM, Shen-Orr SS. High Resolution Longitudinal Immune Profiling Reveals the Dynamics of Healthy Immune-Aging and its Relation to Cardiovascular Risk. Nature Medicine, 2019 (in press)

  2. Luo G, Ambatia A, Ling L, Bonvaleta M, Partinenb M, Ji X, Maecker HM, and Mignot E. Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy. Proceedings of the National Academy of Sciences of the United States of America (PNAS), December 26, 2018 115 (52) E12323-E12332; published ahead of print December 12, 2018. 

  3. Bhattacharya S, Li J, Sockell A, Kan MJ, Bava FA, Chen SC, Ávila-Arcos MC, Ji X, Smith E, Asadi NB, Lachman RS, Lam HYK, Bustamante CD, Butte AJ, Nolan GP. Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia. Genome Res. 2018 Apr; 28(4):423-431. doi: 10.1101/gr.223693.117. Epub 2018 Mar 22.

  4. Glanville J, Huang H, Nau A, Hatton O, Wagar LE, Rubelt F, Ji X, Han A, Krams SM, Pettus C, Haas N, Arlehamn CSL, Sette A, Boyd SD, Scriba TJ, Martinez OM, Davis MM. Identifying specificity groups in the T cell receptor repertoire. Nature. 2017 Jul 6; 547(7661):94-98. doi: 10.1038/nature22976. Epub 2017 Jun 21.

  5. Winger EE, Reed JL, Ji X, Nicolaides K. Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept. PLoS One. 2018 Jan 2; 13(1):e0190654. doi: 10.1371/journal.pone.0190654. eCollection 2018.

  6. Winger EE, Reed JL, Ji X. Early first trimester peripheral blood cell microRNA predicts risk of preterm delivery in pregnant women: Proof of concept. PLoS One. 2017 Jul 10; 12(7):e0180124. doi: 10.1371/journal.pone.0180124. eCollection 2017.

  7. Winger EE, Reed JL, Ji X. First-trimester maternal cell microRNA is a superior pregnancy marker to immunological testing for predicting adverse pregnancy outcome. J Reprod Immunol. 2015 Aug; 110:22-35. doi: 10.1016/j.jri.2015.03.005. Epub 2015 Apr 16.

  8. Winger EE, Reed JL, Ji X. First trimester PBMC microRNA predicts adverse pregnancy outcome. Am J Reprod Immunol. 2014 Nov; 72(5):515-26. doi: 10.1111/aji.12287. Epub 2014 Jun 28.

  9. Ryan JF, Hovde R, Glanville J, Lyu SC, Ji X, Gupta S, Tibshirani RJ, Jay DC, Boyd SD, Chinthrajah RS, Davis MM, Galli SJ, Maecker HT, Nadeau KC. Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets. Proc Natl Acad Sci U S A. 2016 Mar 1; 113(9):E1286-95. doi: 10.1073/pnas.1520180113. Epub 2016 Jan 25.

  10. He Z, Nanda S, Ji X, Calderon-Rodriguez G, Greenberg HB, and Liang TJ.   Differential Transcriptional Responses to Interferon-α and Interferon-γ in Primary Human Hepatocytes.   Journal of Interferon & Cytokine Research, Volume 30(5):311-321, 2010.

  11. Zhong B, Strnad P, Toivola DM, Tao GZ, Ji X, Greenberg HB, Omary MB. Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation. Mol Biol Cell, 2007 Dec; 18(12):4969-78. 2007 Sep 26.

  12. He XS, Ji X, Hale M, Cheung R, Ahmed A, Guo Y, Nolan G, Pfeffer LM, Wright TL, Risch N, Tibshirani R, and Greenberg HB. Global Transcriptional Response to Interferon Is a Determinant of HCV Treatment Outcome and Is Modified by Race. Hepatology, 44(2):352-359, 2006.

  13. Zhou Q, Ji X, Chen L, Greenberg HB, Lu SC, and Omary MB. Keratin Mutation Primes Mouse Liver to Oxidative Injury. Hepatology, 41(3):517-525, March 2005.

  14. Ji X, Cheung R, Cooper S, Li Q, Greenberg HB, and He XS.  Interferon Alfa Regulated Gene Expression in Patients Initiating Interferon Treatment for Chronic Hepatitis C. Hepatology, 37(3):610-621, 2003.

  15. Ji X, Frati F , Barone S , Pagliaccia  C, Burroni D , Xu G, Rappuoli R, Reyrat JM , Telford JL.  Evolution of functional polymorphism in the gene coding for the Helicobacter pylori cytotoxin. FEMS Microbiology Letters, 206 (2002) 253-258.

  16. Ji X, Fernandez T, Burroni D, Pagliaccia C, Atherton JC, Reyrat JM, Rappuoli R, and Telford JL.  Cell Specificity of Helicobacter pylori in the Polymorphic Midregion Cytotoxin Is Determined by a Short Region. Infect. Immun. 2000, 68(6):3754.

  17. Pagliaccia C, Bernard M, Lupetti P, Ji M, Burroni D, Cover TL, Papini E, Rappuoli R, Telford JL, Reyrat JM. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity. Proc. Natl. Acad. Sci. USA Vol. 95, pp. 10212–10217, August 1998 Microbiology.

1 Protocol published
Protein- and Sequencing-based Massively Parallel Single-cell Approaches to Gene Expression Profiling
Authors:  Xuhuai Ji, Igor Goncharov, Miao Zhao, Molly Miranda and Holden T. Maecker, date: 02/05/2019, view: 2192, Q&A: 0
Understanding cellular diversity and dynamics in immune cells are critical for elucidating mechanisms of diagnosis, response to therapeutics, and patient prognosis. Our goal is to apply a technically simple approach for gene expression cytometry ...
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