Amriti Lulla UT MD Anderson Cancer Center
5 protocols

Ruth Franklin Yale University
13 protocols

Scott McComb National Research Council of Canada, Human Health and Thereapeutics Research Centre
0 protocol

Reviewer
mohan babu
  • Post-Doc, University of Eastern Finland
Research focus
  • Molecular biology
  • Tissue repair and angiogenesis in response to ischemic insults in hyperlipidemic and diabetic conditions

Education

PhD, Ita suomen yliopisto, 2018

Lab information

Yla-herttuala's Lab

Publications

1. Babu M, Devi T, Kaikkonen M, Mäkinen P, Laakso H, Liimatainen T, Velagapudi V, Glass CK, Ylä-Herttuala S. Altered macrophage phenotypic transition correlates with impaired vascular growth responses in diabetic mouse model of hindlimb ischemia. Manuscript. 2018.

2. A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. Diabetes. https://doi.org/10.2337/db17-0914 (2018) (part of SUMMIT consortium).
3. Devi T *, Babu M *, Mäkinen P, Kaikkonen M, Heinoniemi M, Laakso H, Ylä-Herttuala E, Rieppo L, Liimatainen T, Naumenko N, Tavi P, Ylä-Herttuala S. Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation. (* Shared first author). Am J Pathol. 2017:187: 2659-2673.

4. Babu M, Devi T, Mäkinen P, Kaikkonen M, Lesch H, Junttila S, Laiho A, Ghimire B, Gyenesei A, Yla-Herttuala S. Differential promoter methylation of macrophage genes is associated with impaired vascular growth in ischemic muscles of hyperlipidemic and type 2 diabetic mice: A Genome-Wide Promoter Methylation Study. Circulation Research. 2015;117:289–299.

5. Bhardwaj S, Roy H, Babu M, Shibuya M, Yla-Herttuala S. Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation. Atherosclerosis. 2011; 219(1): 84-91.

6. Roy H, Bhardwaj S, Babu M, Lähteenvuo J, Ylä-Herttuala S. VEGF-D∆N∆C Mediated Angiogenesis in Skeletal Muscles of Diabetic WHHL Rabbits. Eur J Clin Invest. 2010; 40(5): 422-32.

7. Viita H, Kinnunen K, Eriksson E, Lähteenvuo J, Babu M, Kalesnykas G, Heikura T, Laidinen S, Takalo T, Ylä-Herttuala S. Intravitreal adenoviral 15-lipoxygenase-1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes. Hum Gene Ther. 2009; 20(12): 1679-86.

8. Viita H, Markkanen J, Eriksson E, Nurminen M, Kinnunen K, Babu M, Heikura T, Turpeinen S, Laidinen S, Takalo T, Ylä-Herttuala S. 15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and down regulation of VEGF receptor 2 expression. Circulation Research. 2008; 102(2): 177-84.

9. Räty S, Piironen A, Babu M, Pelli H , Sand J, Uotila S, Nordback I, Herzig KH. Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish hereditary pancreatitis family. Scand J Gastroenterol. 2007; 42(8):1000-5.

10. Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig KH, Yla-Herttuala S. VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits. FASEB J. 2006; 20(12):2159-61.

11. Roy H, Bhardwaj S, Babu M, Jauhiainen S, Herzig KH, Haisma HJ, Carmeliet P, Alitalo K, Ylä-Herttuala S . Adenovirus mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via up regulation of the expression of endogenous vascular endothelial growth factor-A. Human Gene Therapy. 2005; 16(12):1422-8.

12. Kumar A, Babu M, Kimberling WJ, Venkatesh CP. Genetic analysis of a four-generation Indian family with Usher syndrome: a novel insertion mutation in MYO7A. Molecular Vision. 2004; 10:910-6.

13. Kumar A, Babu M, Raghunath A, Venkatesh CP. Genetic analysis of a five generation Indian family with BPES: A novel missense mutation (p. Y215C). Molecular Vision. 2004; 10:445-9.

14. Kumar A, Blanton SH, Babu M, Markandaya M, Girimaji SC.Genetic analysis of primary microcephaly in Indian families: novel ASPM mutations. Clin Genet. 2004; 66(4):341-8.
1 Protocol reviewed
A New Efficient Method for Measuring Oxygen Consumption Rate Directly ex vivo in Human Epidermal Biopsies
Authors:  Daniel Schniertshauer, Daniel Gebhard and Jörg Bergemann, date: 03/05/2019, view: 456, Q&A: 0
Skin cells are constantly exposed to environmental influences such as air pollution, chemicals, pathogens and UV radiation. UV radiation can damage different biological structures, but most importantly cellular DNA. Mitochondria contain their own ...
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