Rafael Maldonado Laboratory of Neuropharmacology. Department of Experimental and Health Sciences , Universitat Pompeu Fabra, Spain
3 protocols

Andrés Ozaita 1 protocol

Giovanni Marsicano INSERM U1215 NEUROCENTRE MAGENDIE, UNIVERSITE DE BORDEAUX, FRANCE
5 protocols

Alexandra Gros CNES - University of Bordeaux (IMN)
7 protocols

Andrew Eagle Michigan State University
6 protocols

Edgar Soria-Gomez Faculty of Medicine and Nursery, University of the Basque Country
25 protocols

Emma Puighermanal Universitat Autònoma de Barcelona
4 protocols

Editor
Arnau Busquets-Garcia
  • Junior researcher, IMIM, Parc de Recerca Biomedica, 2019-
Research focus
  • Neuroscience
  • 3 Author merit

Education

PhD, University Pompeu Fabra, 2009

Publications

1. Busquets-Garcia, A., Soria-Gomez, E., Redon, B., Mackenbach, Y., Vallee, M., Chaouloff, F., Varilh, M., Ferreira, G., Piazza, P. V. and Marsicano, G. (2017). Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice. Mol Psychiatry.
2. Saravia, R., Flores, A., Plaza-Zabala, A., Busquets-Garcia, A., Pastor, A., de la Torre, R., Di Marzo, V., Marsicano, G., Ozaita, A., Maldonado, R. and Berrendero, F. (2017). CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. Biol Psychiatry 81(7): 625-634.
3. Hebert-Chatelain, E., Desprez, T., Serrat, R., Bellocchio, L., Soria-Gomez, E., Busquets-Garcia, A., Pagano Zottola, A. C., Delamarre, A., Cannich, A., Vincent, P., Varilh, M., Robin, L. M., Terral, G., Garcia-Fernandez, M. D., Colavita, M., Mazier, W., Drago, F., Puente, N., Reguero, L., Elezgarai, I., Dupuy, J. W., Cota, D., Lopez-Rodriguez, M. L., Barreda-Gomez, G., Massa, F., Grandes, P., Benard, G. and Marsicano, G. (2016). A cannabinoid link between mitochondria and memory. Nature 539(7630): 555-559.
4. Gomis-Gonzalez, M., Busquets-Garcia, A., Matute, C., Maldonado, R., Mato, S. and Ozaita, A. (2016). Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model. Genes (Basel) 7(9).
5. Ramos-Fernandez, E., Tajes, M., Ill-Raga, G., Vargas, L., Busquets-Garcia, A., Bosch-Morato, M., Guivernau, B., Valls-Comamala, V., Gomis, M., Grau, C., Fandos, C., Rosen, M. D., Rabinowitz, M. H., Inestrosa, N., Maldonado, R., Altafaj, X., Ozaita, A., Alvarez, A., Vicente, R., Valverde, M. A. and Munoz, F. J. (2016). Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2alpha kinase in cortical neurons. Oncotarget 7(37): 58876-58892.
6. Busquets-Garcia, A., Gomis-Gonzalez, M., Srivastava, R. K., Cutando, L., Ortega-Alvaro, A., Ruehle, S., Remmers, F., Bindila, L., Bellocchio, L., Marsicano, G., Lutz, B., Maldonado, R. and Ozaita, A. (2016). Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci U S A 113(35): 9904-9909.
7. Busquets Garcia, A., Soria-Gomez, E., Bellocchio, L. and Marsicano, G. (2016). Cannabinoid receptor type-1: breaking the dogmas. F1000Res 5.
8. Busquets-Garcia, A., Desprez, T., Metna-Laurent, M., Bellocchio, L., Marsicano, G. and Soria-Gomez, E. (2015). Dissecting the cannabinergic control of behavior: The where matters. Bioessays 37(11): 1215-1225.
9. Soria-Gomez, E., Busquets-Garcia, A., Hu, F., Mehidi, A., Cannich, A., Roux, L., Louit, I., Alonso, L., Wiesner, T., Georges, F., Verrier, D., Vincent, P., Ferreira, G., Luo, M. and Marsicano, G. (2015). Habenular CB1 Receptors Control the Expression of Aversive Memories. Neuron 88(2): 306-313.
10. Ill-Raga, G., Tajes, M., Busquets-Garcia, A., Ramos-Fernandez, E., Vargas, L. M., Bosch-Morato, M., Guivernau, B., Valls-Comamala, V., Eraso-Pichot, A., Guix, F. X., Fandos, C., Rosen, M. D., Rabinowitz, M. H., Maldonado, R., Alvarez, A. R., Ozaita, A. and Munoz, F. J. (2015). Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2alpha Kinase HRI Induces Synaptogenesis. Antioxid Redox Signal 22(15): 1295-1307.
11. Busquets-Garcia, A., Maldonado, R. and Ozaita, A. (2014). New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model. Int J Biochem Cell Biol 53: 121-126.
12. Busquets-Garcia, A., Gomis-Gonzalez, M., Guegan, T., Agustin-Pavon, C., Pastor, A., Mato, S., Perez-Samartin, A., Matute, C., de la Torre, R., Dierssen, M., Maldonado, R. and Ozaita, A. (2013). Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nat Med 19(5): 603-607.
13. Garcia-Gutierrez, M. S., Ortega-Alvaro, A., Busquets-Garcia, A., Perez-Ortiz, J. M., Caltana, L., Ricatti, M. J., Brusco, A., Maldonado, R. and Manzanares, J. (2013). Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors. Neuropharmacology 73: 388-396.
14. Cutando, L., Busquets-Garcia, A., Puighermanal, E., Gomis-Gonzalez, M., Delgado-Garcia, J. M., Gruart, A., Maldonado, R. and Ozaita, A. (2013). Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure. J Clin Invest 123(7): 2816-2831.
15. Puighermanal, E., Busquets-Garcia, A., Gomis-Gonzalez, M., Marsicano, G., Maldonado, R. and Ozaita, A. (2013). Dissociation of the pharmacological effects of THC by mTOR blockade. Neuropsychopharmacology 38(7): 1334-1343.
16. Puighermanal, E., Busquets-Garcia, A., Maldonado, R. and Ozaita, A. (2012). Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. Philos Trans R Soc Lond B Biol Sci 367(1607): 3254-3263.
17. Busquets-Garcia, A., Puighermanal, E., Pastor, A., de la Torre, R., Maldonado, R. and Ozaita, A. (2011). Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biol Psychiatry 70(5): 479-486.
18. Puighermanal, E., Marsicano, G., Busquets-Garcia, A., Lutz, B., Maldonado, R. and Ozaita, A. (2009). Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat Neurosci 12(9): 1152-1158.
19. Comas, D., Schmid, H., Braeuer, S., Flaiz, C., Busquets, A., Calafell, F., Bertranpetit, J., Scheil, H. G., Huckenbeck, W., Efremovska, L. and Schmidt, H. (2004). Alu insertion polymorphisms in the Balkans and the origins of the Aromuns. Ann Hum Genet 68(Pt 2): 120-127.
3 Protocols published
An Alternative Maze to Assess Novel Object Recognition in Mice
The novel object recognition (NOR) task is a behavioral test commonly used to evaluate episodic-like declarative memory and it relies on the innate tendency of rodents to explore novelty. Here we present a maze used to evaluate NOR memory in mice ...
Assessing Prepulse Inhibition of Startle in Mice
Authors:  Christina Ioannidou, Giovanni Marsicano and Arnau Busquets-Garcia, date: 04/05/2018, view: 7382, Q&A: 0
Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce ‘core’ symptoms of complex human disorders such as schizophrenia. Despite ...
4 Protocols reviewed
Assessing Classical Olfactory Fear Conditioning by Behavioral Freezing in Mice
Authors:  Jordan M. Ross and Max L. Fletcher, date: 09/20/2018, view: 2808, Q&A: 0
Classical fear conditioning typically involves pairing a discrete cue with a foot shock. Quantifying behavioral freezing to the learned cue is a crucial assay for neuroscience studies focused on learning and memory. Many paradigms utilize discrete ...
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Evaluating Working Memory on a T-maze in Male Rats
Authors:  Ahmed M. Hussein, Mekite Bezu and Volker Korz, date: 07/20/2018, view: 5869, Q&A: 0
Working memory is short-term memory, so temporal improvement does not reflect the consolidation of a memory trace, rather the functionality of the underlying neuronal circuits and molecular signaling cascades. The administration of drugs–either ...
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11 Protocols edited
Measuring Breathing Patterns in Mice Using Whole-body Plethysmography
Respiratory dysfunction is among the main cause of severe and fatal pathologies worldwide. The use of effective experimental models and methodologies for the study of the pulmonary pathophysiology is necessary to prevent, control and cure these ...
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The Discrete Paired-trial Variable-delay T-maze Task to Assess Working Memory in Mice
Authors:  Gian Marco Leggio, Sebastiano Alfio Torrisi and Francesco Papaleo, date: 07/05/2020, view: 591, Q&A: 0
Working memory abnormalities involving the prefrontal cortex (PFC) dramatically contribute to poor functional outcomes in patients with schizophrenia and still represent an unmet therapeutic need. Studies in rodents might provide essential tools to ...
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