Päivi Ojala Imperial College London and University of Helsinki
1 protocol

Silvia Gramolelli Research Programs Unit, Translational Cancer Biology, University of Helsinki, Finland, Finland,
1 protocol

Sanni Alve Research Programs Unit, Translational Cancer Biology, University of Helsinki, Finland, Finland,
1 protocol

Ilkka Paatero Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland, Finland,
1 protocol

Johanna Ivaska
  • Turku Centre for Biotechnology and Department of Biochemistry, University of Turku and Åbo Akademi University, Finland
  • 2 Author merit


PhD, University of Turku, Finland, 2000

Current position

Academy Professor/Professor, Turku centre for Biotechnology, University of Turku, Finland

Publications (since 2015)

  1. Jacquemet, G., Paatero, I., Carisey, A. F., Padzik, A., Orange, J. S., Hamidi, H. and Ivaska, J. (2017). FiloQuant reveals increased filopodia density during breast cancer progression. J Cell Biol 216(10): 3387-3403.
  2. Georgiadou, M. and Ivaska, J. (2017). Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation. Trends Cell Biol 27(10): 703-711.
  3. Narva, E., Stubb, A., Guzman, C., Blomqvist, M., Balboa, D., Lerche, M., Saari, M., Otonkoski, T. and Ivaska, J. (2017). A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion. Stem Cell Reports 9(1): 67-76.
  4. Georgiadou, M., Lilja, J., Jacquemet, G., Guzman, C., Rafaeva, M., Alibert, C., Yan, Y., Sahgal, P., Lerche, M., Manneville, J. B., Makela, T. P. and Ivaska, J. (2017). AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol 216(4): 1107-1121.
  5. Lilja, J., Zacharchenko, T., Georgiadou, M., Jacquemet, G., De Franceschi, N., Peuhu, E., Hamidi, H., Pouwels, J., Martens, V., Nia, F. H., Beifuss, M., Boeckers, T., Kreienkamp, H. J., Barsukov, I. L. and Ivaska, J. (2017). SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Nat Cell Biol 19(4): 292-305.
  6. Peuhu, E., Kaukonen, R., Lerche, M., Saari, M., Guzman, C., Rantakari, P., De Franceschi, N., Warri, A., Georgiadou, M., Jacquemet, G., Mattila, E., Virtakoivu, R., Liu, Y., Attieh, Y., Silva, K. A., Betz, T., Sundberg, J. P., Salmi, M., Deugnier, M. A., Eliceiri, K. W. and Ivaska, J. (2017). SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland. EMBO J 36(2): 165-182.
  7. Jacquemet, G., Baghirov, H., Georgiadou, M., Sihto, H., Peuhu, E., Cettour-Janet, P., He, T., Perala, M., Kronqvist, P., Joensuu, H. and Ivaska, J. (2016). L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. Nat Commun 7: 13297.
  8. Hamidi, H., Pietila, M. and Ivaska, J. (2016). The complexity of integrins in cancer and new scopes for therapeutic targeting. Br J Cancer 115(9): 1017-1023.
  9. Rantakari, P., Jappinen, N., Lokka, E., Mokkala, E., Gerke, H., Peuhu, E., Ivaska, J., Elima, K., Auvinen, K. and Salmi, M. (2016). Fetal liver endothelium regulates the seeding of tissue-resident macrophages. Nature 538(7625): 392-396.
  10. Kaukonen, R., Mai, A., Georgiadou, M., Saari, M., De Franceschi, N., Betz, T., Sihto, H., Ventela, S., Elo, L., Jokitalo, E., Westermarck, J., Kellokumpu-Lehtinen, P. L., Joensuu, H., Grenman, R. and Ivaska, J. (2016). Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun 7: 12237.
  11. Barrow-McGee, R., Kishi, N., Joffre, C., Menard, L., Hervieu, A., Bakhouche, B. A., Noval, A. J., Mai, A., Guzman, C., Robert-Masson, L., Iturrioz, X., Hulit, J., Brennan, C. H., Hart, I. R., Parker, P. J., Ivaska, J. and Kermorgant, S. (2016). Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nat Commun 7: 11942.
  12. Cheng, F., Shen, Y., Mohanasundaram, P., Lindstrom, M., Ivaska, J., Ny, T. and Eriksson, J. E. (2016). Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-beta-Slug signaling. Proc Natl Acad Sci U S A 113(30): E4320-4327.
  13. Pietila, M., Ivaska, J. and Mani, S. A. (2016). Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment? Cancer Lett 380(1): 359-368.
  14. Alanko, J. and Ivaska, J. (2016). Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling. Trends Cell Biol 26(6): 391-398.
  15. Ratcliffe, C. D., Sahgal, P., Parachoniak, C. A., Ivaska, J. and Park, M. (2016). Regulation of Cell Migration and beta1 Integrin Trafficking by the Endosomal Adaptor GGA3. Traffic 17(6): 670-688.
  16. De Franceschi, N., Arjonen, A., Elkhatib, N., Denessiouk, K., Wrobel, A. G., Wilson, T. A., Pouwels, J., Montagnac, G., Owen, D. J. and Ivaska, J. (2016). Selective integrin endocytosis is driven by interactions between the integrin alpha-chain and AP2. Nat Struct Mol Biol 23(2): 172-179.
  17. Alanko, J., Mai, A., Jacquemet, G., Schauer, K., Kaukonen, R., Saari, M., Goud, B. and Ivaska, J. (2015). Integrin endosomal signalling suppresses anoikis. Nat Cell Biol 17(11): 1412-1421.
  18. Jacquemet, G., Hamidi, H. and Ivaska, J. (2015). Filopodia in cell adhesion, 3D migration and cancer cell invasion. Curr Opin Cell Biol 36: 23-31.
  19. De Franceschi, N., Peuhu, E., Parsons, M., Rissanen, S., Vattulainen, I., Salmi, M., Ivaska, J. and Pouwels, J. (2015). Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-kappaB Signaling. PLoS One 10(11): e0143423.
  20. Wang, Y., Arjonen, A., Pouwels, J., Ta, H., Pausch, P., Bange, G., Engel, U., Pan, X., Fackler, O. T., Ivaska, J. and Grosse, R. (2015). Formin-like 2 Promotes beta1-Integrin Trafficking and Invasive Motility Downstream of PKCalpha. Dev Cell 34(4): 475-483.
  21. Virtakoivu, R., Mai, A., Mattila, E., De Franceschi, N., Imanishi, S. Y., Corthals, G., Kaukonen, R., Saari, M., Cheng, F., Torvaldson, E., Kosma, V. M., Mannermaa, A., Muharram, G., Gilles, C., Eriksson, J., Soini, Y., Lorens, J. B. and Ivaska, J. (2015). Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function. Cancer Res 75(11): 2349-2362.
  22. Hakanpaa, L., Sipila, T., Leppanen, V. M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K. and Saharinen, P. (2015). Endothelial destabilization by angiopoietin-2 via integrin beta1 activation. Nat Commun 6: 5962.
  23. Weber-Boyvat, M., Kentala, H., Lilja, J., Vihervaara, T., Hanninen, R., Zhou, Y., Peranen, J., Nyman, T. A., Ivaska, J. and Olkkonen, V. M. (2015). OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. Exp Cell Res 331(2): 278-291.
2 Protocols published
Zebrafish Embryo Xenograft and Metastasis Assay
Authors:  Ilkka Paatero, Sanni Alve, Silvia Gramolelli, Johanna Ivaska and Päivi M. Ojala, date: 09/20/2018, view: 3927, Q&A: 1
Xenograft models, and in particular the mouse xenograft model, where human cancer cells are transplanted into immunocompromised mice, have been used extensively in cancer studies. Although these models have contributed enormously to our ...
Using xCELLigence RTCA Instrument to Measure Cell Adhesion
Authors:  Hellyeh Hamidi, Johanna Lilja and Johanna Ivaska, date: 12/20/2017, view: 5358, Q&A: 0
Cell adhesion to neighbouring cells and to the underlying extracellular matrix (ECM) is a fundamental requirement for the existence of multicellular organisms. As such, the formation, stability and dissociation of cell adhesions are subject to tight ...
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