Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
Authors
Xinmei Wen, Wenzhi Tan, Thomas Westergard, Karthik Krishnamurthy, Yingxiao Markandaiah S Shashirekha .,Shi, Shaoyu Lin, A Neil Shneider, John Monaghan, Udai B Pandey, P Pasinelli, Justin K Ichida, Davide Trotti
Publication date
2014/12/17
Journal
Neuron
Volume
84
Issue
6
Pages
1213-1225
Publisher
Cell Press

Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity
Authors
J Gavin Daigle, Karthik Krishnamurthy, Nandini Ramesh, Ian Casci, John Monaghan, Kevin McAvoy, Earl W Godfrey, Dianne C Daniel, Edward M Johnson, Zachary Monahan, Frank Shewmaker, Piera Pasinelli, Udai Bhan Pandey
Publication date
2016/4/1
Journal
Acta neuropathologica
Volume
131
Issue
4
Pages
605-620
Publisher
Springer Berlin Heidelberg

AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor
Authors
Dinesh C Joshi, Mahendra Singh, Karthik Krishnamurthy, Preeti G Joshi, Nanda B Joshi
Publication date
2011/11/1
Journal
Neurochemistry international
Volume
59
Issue
6
Pages
913-921
Publisher
Pergamon


Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha
Authors
Azadeh Kia, Kevin McAvoy, Karthik Krishnamurthy, Davide Trotti, Piera Pasinelli
Publication date
2018
Journal
Glia
Volume
23298
Issue
doi: 10.1002/glia.23298.
Pages
doi: 10.1002/glia.23298.
Publisher
Wiley


Depalmitoylation preferentially downregulates AMPA induced Ca2+ signaling and neurotoxicity in motor neurons
Authors
Karthik Krishnamurthy, Bhupesh Mehta, Mahendra Singh, Bhanu P Tewari, Preeti G Joshi, Nanda B Joshi
Publication date
2013/9/5
Journal
Brain research
Volume
1529
Pages
143-153
Publisher
Elsevier