Abhinit Nagar UMass Medical School, Worcestor, MA
3 protocols

Ali Kermani University of Michigan, Ann Arbor
8 protocols

Amberley Stephens Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge
3 protocols

ASWAD KHADILKAR UNIVERSITY OF CALIFORNIA SANTA CRUZ
11 protocols

Editor
Alessandro Didonna
  • Assistant Adjunct Professor, University of California, San Francisco
Research focus
  • Neuroscience
  • Neurodegeneration; Multiple Sclerosis; Autoimmunity; Protein Misfolding; Movement Disorders.
  • 0 Author merit

Education

Ph.D. in Functional and Structural Genomics, International School for Advanced Studies (SISSA), 2010

Lab information

Multiple Sclerosis Genetics Research Lab

Publications

1. The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells. Mol Brain. 2021 Jan 21; 14(1):19.Ma Q, Didonna A. PMID: 33478569.

2. A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain. Immunology. 2021 Feb; 162(2):194-207.Didonna A, Damotte V, Shams H, Matsunaga A, Caillier SJ, Dandekar R, Misra MK, Mofrad MRK, Oksenberg JR, Hollenbach JA. PMID: 32986852.

3. Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020 Oct 12; 17(1):297.Ma Q, Matsunaga A, Ho B, Oksenberg JR, Didonna A. PMID: 33046105.

4. Tau at the interface between neurodegeneration and neuroinflammation. Genes Immun. 2020 11; 21(5):288-300.Didonna A. PMID: 33011744.

5. Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proc Natl Acad Sci USA. 2020 09 22; 117(38):23742-23750.Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR. PMID: 32878998.

6. TopoDB: a novel multifunctional management system for laboratory animal colonies. Database (Oxford). 2020 Jan 01; 2020.Renschen A, Matsunaga A, Oksenberg JR, Santaniello A, Didonna A. PMID: 33206961.

7. Mitoma H. Manto M. (eds) Neuroimmune Diseases. Contemporary Clinical Neuroscience. Genetic Factors in Neuroimmune Diseases. 2019; 357-386 .Didonna A,
Cantó E. View Publication.

8. The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders. Mol Neurodegener. 2019 05 16; 14(1):19.Didonna A, Opal P. PMID: 31097008.

9. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. J Autoimmun. 2019 07; 101:56-69.Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. PMID: 31010726.

10. Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Hum Mol Genet. 2019 04 15; 28(8):1343-1356.Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P. PMID: 30590536.

11. Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 06 01; 128(6):2252-2265.Edamakanti CR, Do J, Didonna A, Martina M, Opal P. PMID: 29533923.

12. Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. J Neuroinflammation. 2018 Mar 07; 15(1):72.Canto E, Isobe N, Didonna A, Hauser SL, Oksenberg JR. PMID: 29514694.

13. The Genetics of Multiple Sclerosis. Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. 2017 Nov 14; 3-16.ALESSANDRO DIDONNA, JORGE R. OKSENBERG. .

14. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci USA. 2017 08 15; 114(33):E6982-E6991.Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. PMID: 28760957.

15. Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurol. 2016 Dec 01; 73(12):1485-1490.Didonna A, Opal P. PMID: 27749953.

16. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 08 22; 6:31603.Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. PMID: 27546286.

17. Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Curr Med Chem. 2016; 23(14):1442-59.Didonna A. PMID: 27048376.

18. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8.Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. PMID: 26433934.

19. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 2015; 3:e811.Didonna A, Venturini AC, Hartman K, Vranac T, Curin Šerbec V, Legname G. PMID: 25802800.

20. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22.Didonna A, Oksenberg JR. PMID: 25661088.

21. Post-translational modifications in neurodegeneration. AIMS Biophysics. 2015 Jan 1; 3(1):27-49.Alessandro Didonna, Federico Benetti. .

22. The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol. 2015 Jan; 2(1):79-101.Didonna A, Opal P. PMID: 25642438.

23. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15; 23(14):3733-45.Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. PMID: 24594842.

24. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May; 123(5):1964-75.Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. PMID: 23585478.

25. Prion protein and its role in signal transduction. Cell Mol Biol Lett. 2013 Jun; 18(2):209-30.Didonna A. PMID: 23479001.

26. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012 Jul 01; 6(3):309-16.Didonna A, Sussman J, Benetti F, Legname G. PMID: 22561161.

27. Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS Chem Neurosci. 2011 Mar 16; 2(3):160-74.Didonna A, Vaccari L, Bek A, Legname G. PMID: 22778865.

28. Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener. 2010 Aug 09; 5:29.Didonna A, Legname G. PMID: 20696038.
6 Protocols reviewed
Purifying Properly Folded Cysteine-rich, Zinc Finger Containing Recombinant Proteins for Structural Drug Targeting Studies: the CH1 Domain of p300 as a Case Example
Authors:  Yong Joon Kim, Stefan Kaluz, Anil Mehta, Emily Weinert, Shannon Rivera and Erwin G. Van Meir, date: 09/05/2017, view: 10771, Q&A: 0
The transcription factor Hypoxia-Inducible Factor (HIF) complexes with the coactivator p300, activating the hypoxia response pathway and allowing tumors to grow. The CH1 and CAD domains of each respective protein form the interface between p300 and ...
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An ex vivo Perifusion Method for Quantitative Determination of Neuropeptide Release from Mouse Hypothalamic Explants
Authors:  Ophélia Le Thuc, Jacques Noël and Carole Rovère, date: 08/20/2017, view: 6005, Q&A: 0
The hypothalamus is a primary brain area which, in mammals, regulates several physiological functions that are all related to maintaining general homeostasis, by linking the central nervous system (CNS) and the periphery. The hypothalamus itself can ...
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45 Protocols edited
One-step White Blood Cell Extracellular Staining Method for Flow Cytometry

Flow cytometry is a powerful analytical technique that is increasingly used in scientific investigations and healthcare; however, it requires time-consuming, multi-step sample procedures, which limits its use to specialized laboratories. In this

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A Novel Method to Make Polyacrylamide Gels with Mechanical Properties Resembling those of Biological Tissues
Authors:  Katarzyna Pogoda, Elisabeth E. Charrier and Paul A. Janmey, date: 08/20/2021, view: 934, Q&A: 0

Studies characterizing how cells respond to the mechanical properties of their environment have been enabled by the use of soft elastomers and hydrogels as substrates for cell culture. A limitation of most such substrates is that, although

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