Assistant Professor, School of Biological Science, College of Science, Nanyang Technological University, Singapore
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Loh, J. T. and Su, I. H. (2016). Post-translational modification-regulated leukocyte adhesion and migration. Oncotarget 7(24): 37347-37360.
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Gunawan, M., Venkatesan, N., Loh, J. T., Wong, J. F., Berger, H., Neo, W. H., Li, L. Y., La Win, M. K., Yau, Y. H., Guo, T., See, P. C., Yamazaki, S., Chin, K. C., Gingras, A. R., Shochat, S. G., Ng, L. G., Sze, S. K., Ginhoux, F. and Su, I. H. (2015). The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat Immunol 16(5): 505-516.
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Neo, W. H., Lim, J. F., Grumont, R., Gerondakis, S. and Su, I. H. (2014). c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells. J Biol Chem 289(46): 31693-31707.
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Neo, W. H., Yap, K., Lee, S. H., Looi, L. S., Khandelia, P., Neo, S. X., Makeyev, E. V. and Su, I. H. (2014). MicroRNA miR-124 controls the choice between neuronal and astrocyte differentiation by fine-tuning Ezh2 expression. J Biol Chem 289(30): 20788-20801.
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Caganova, M., Carrisi, C., Varano, G., Mainoldi, F., Zanardi, F., Germain, P. L., George, L., Alberghini, F., Ferrarini, L., Talukder, A. K., Ponzoni, M., Testa, G., Nojima, T., Doglioni, C., Kitamura, D., Toellner, K. M., Su, I. H. and Casola, S. (2013). Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J Clin Invest 123(12): 5009-5022.
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Chan, Y. S., Goke, J., Lu, X., Venkatesan, N., Feng, B., Su, I. H. and Ng, H. H. (2013). A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells 31(4): 682-692.
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Wyngaarden, L. A., Delgado-Olguin, P., Su, I. H., Bruneau, B. G. and Hopyan, S. (2011). Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development 138(17): 3759-3767.
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Wang, L., Jin, Q., Lee, J. E., Su, I. H. and Ge, K. (2010). Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis. Proc Natl Acad Sci U S A 107(16): 7317-7322.
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Xu, S., Huo, J., Gunawan, M., Su, I. H. and Lam, K. P. (2009). Activated dectin-1 localizes to lipid raft microdomains for signaling and activation of phagocytosis and cytokine production in dendritic cells. J Biol Chem 284(33): 22005-22011.
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Chen, H., Gu, X., Su, I. H., Bottino, R., Contreras, J. L., Tarakhovsky, A. and Kim, S. K. (2009). Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev 23(8): 975-985.
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Ezhkova, E., Pasolli, H. A., Parker, J. S., Stokes, N., Su, I. H., Hannon, G., Tarakhovsky, A. and Fuchs, E. (2009). Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136(6): 1122-1135.
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Su, I. H. and Tarakhovsky, A. (2006). Lysine methylation and 'signaling memory'. Curr Opin Immunol 18(2): 152-157.
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Su, I. H., Dobenecker, M. W., Dickinson, E., Oser, M., Basavaraj, A., Marqueron, R., Viale, A., Reinberg, D., Wulfing, C. and Tarakhovsky, A. (2005). Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell 121(3): 425-436.
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Su, I. H. and Tarakhovsky, A. (2005). Epigenetic control of B cell differentiation. Semin Immunol 17(2): 167-172.
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Erhardt, S., Su, I. H., Schneider, R., Barton, S., Bannister, A. J., Perez-Burgos, L., Jenuwein, T., Kouzarides, T., Tarakhovsky, A. and Surani, M. A. (2003). Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130(18): 4235-4248.
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Saijo, K., Schmedt, C., Su, I. H., Karasuyama, H., Lowell, C. A., Reth, M., Adachi, T., Patke, A., Santana, A. and Tarakhovsky, A. (2003). Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol 4(3): 274-279.
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Su, I. H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T. and Tarakhovsky, A. (2003). Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol 4(2): 124-131.
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Yokoyama, K., Su Ih, I. H., Tezuka, T., Yasuda, T., Mikoshiba, K., Tarakhovsky, A. and Yamamoto, T. (2002). BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J 21(1-2): 83-92.
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Ogata, H., Su, I., Miyake, K., Nagai, Y., Akashi, S., Mecklenbrauker, I., Rajewsky, K., Kimoto, M. and Tarakhovsky, A. (2000). The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med 192(1): 23-29.
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Su, I. and Tarakhovsky, A. (2000). B-1 cells: orthodox or conformist? Curr Opin Immunol 12(2): 191-194.
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Texido, G., Su, I. H., Mecklenbrauker, I., Saijo, K., Malek, S. N., Desiderio, S., Rajewsky, K. and Tarakhovsky, A. (2000). The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Mol Cell Biol 20(4): 1227-1233.
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Chan, V. W., Mecklenbrauker, I., Su, I., Texido, G., Leitges, M., Carsetti, R., Lowell, C. A., Rajewsky, K., Miyake, K. and Tarakhovsky, A. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med 188(1): 93-101.