Richard Higashi Center for Environmental Systems Biochemistry, Dept. Toxicology and Cancer Biology and Markey Cancer Center, USA
1 protocol

Teresa Fan Center for Environmental Systems Biochemistry, Dept. Toxicology and Cancer Biology and Markey Cancer Center, USA
2 protocols

Jun Yan JG Brown Cancer Center, University of Louisville, Clinical & Translational Research Building, University of Louisville, USA
1 protocol

Andrew N. Lane
  • Center for Environmental Systems Biochemistry, Dept. Toxicology and Cancer Biology and Markey Cancer Center, USA
Research focus
  • Cancer biology
  • 2 Author merit


Ph.D. in Biochemistry, University College London, 1979

Current position

Professor, Department of Toxicology & Cancer Biology, University of Kentucky (2013-present)
Co-director Center Environmental Systems Biochemistry (2014-present)


  1. Sellers, K., Fox, M. P., Bousamra, M., 2nd, Slone, S. P., Higashi, R. M., Miller, D. M., Wang, Y., Yan, J., Yuneva, M. O., Deshpande, R., Lane, A. N.* and Fan, T. W.* (2015). Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest 125(2): 687-698.
  2. Saxena, N., Maio, N., Crooks, D. R., Ricketts, C. J., Yang, Y., Wei, M. H., Fan, T. W., Lane, A. N., Sourbier, C., Singh, A., Killian, J. K., Meltzer, P. S., Vocke, C. D., Rouault, T. A. and Linehan, W. M. (2015). SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery. J Natl Cancer Inst 108(1).
  3. Liu, M., Luo, F., Ding, C., Albeituni, S., Hu, X., Ma, Y., Cai, Y., McNally, L., Sanders, M. A., Jain, D., Kloecker, G., Bousamra, M., 2nd, Zhang, H. G., Higashi, R. M., Lane, A. N., Fan, T. W. and Yan, J. (2015). Dectin-1 Activation by a Natural Product beta-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. J Immunol 195(10): 5055-5065.
  4. Xie, H., Hanai, J., Ren, J. G., Kats, L., Burgess, K., Bhargava, P., Signoretti, S., Billiard, J., Duffy, K. J., Grant, A., Wang, X., Lorkiewicz, P. K., Schatzman, S., Bousamra, M., 2nd, Lane, A. N., Higashi, R. M., Fan, T. W., Pandolfi, P. P., Sukhatme, V. P. and Seth, P. (2014). Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell Metab 19(5): 795-809.
  5. Le, A., Lane, A. N., Hamaker, M., Bose, S., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., Zimmerman. L. J., Liebler, D. C., Slebos, R. J. C., Lorkiewicz, P. K., Higashi, R. M., Fan, T. W. M. and Dang, C. V. (2012). Myc induction of hypoxic glutamine metabolism and a glucose-independent TCA cycle in human B lymphocytes. Cell Metab 15: 110-121.
  6. Fan, T. W., Lane, A. N., Higashi, R. M. and Yan, J. (2011). Stable isotope resolved metabolomics of lung cancer in a SCID mouse model. Metabolomics 7(2): 257-269.
  7. Miller, M. C., Buscaglia, R., Chaires, J. B., Lane, A. N. and Trent, J. O. (2010). Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3' sequence of d(AG3(TTAG3)3). J Am Chem Soc 132(48): 17105-17107.
  8. Dailey, M. M., Miller, M. C., Bates, P. J., Lane, A. N.* and Trent, J. O.* (2010). Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence. Nucleic Acids Res 38(14): 4877-4888.
  9. Fan, T. W., Lane, A. N., Higashi, R. M., Farag, M. A., Gao, H., Bousamra, M. and Miller, D. M. (2009). Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 8: 41.
  10. Lane, A. N.*, Chaires, J. B., Gray, R. D. and Trent, J. O. (2008). Stability and kinetics of G-quadruplex structures. Nucleic Acids Res 36(17): 5482-5515.
  11. Gyi, J. I., Gao, D., Conn, G. L., Trent, J. O., Brown, T. and Lane, A. N.* (2003). The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications. Nucleic Acids Res 31(10): 2683-2693.
  12. McIntosh, P. B., Taylor, I. A., Frenkiel, T. A., Smerdon, S. J. and Lane, A. N.* (2000). The influence of DNA binding on the backbone dynamics of the yeast cell-cycle protein Mbp1. J Biomol NMR 16(3): 183-196.

2 Protocols published
Stable Isotope Resolved Metabolomics Studies in ex vivo TIssue Slices
Authors:  Teresa W-M. Fan, Andrew N. Lane and Richard M. Higashi, date: 02/05/2016, view: 7525, Q&A: 0
An important component of this methodology is to assess the role of the tumor microenvironment on tumor growth and survival. To tackle this problem, we have adapted the original approach of Warburg (Warburg, 1923), by combining thin tissue slices ...
13C Tracer Studies of Metabolism in Mouse Tumor Xenografts
Authors:  Andrew N. Lane, Jun Yan and Teresa W-M. Fan, date: 11/20/2015, view: 8675, Q&A: 0
Mice are widely used for human tumor xenograft studies of cancer development and drug efficacy and toxicity. Stable isotope tracing coupled with metabolomic analysis is an emerging approach for assaying metabolic network activity. In mouse models ...
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