Wei Cui Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, UK
1 protocol
Hui Zhu Stanford University
17 protocols

Miao He Institute of Brain Science, Fudan University
4 protocols

Nicoletta Cordani University of Milano-Bicocca
22 protocols

Oneil Bhalala Baker Institute
48 protocols

Reviewer
Patrick Ovando-Roche
  • Biotech engineer, CRISPR Therapeutics
Research focus
  • Stem cell
  • Stem Cells. Retina. Brain. Neurology. Spinocerebellar Ataxia. Parkinson's Disease
  • 1 Author merit

Education

PhD, Imperial College London, 2014

Publications

1. Ovando-Roche, P., E. L. West, M. J. Branch, R. D. Sampson, M. Fernando, P. Munro, A. Georgiadis, M. Rizzi, M. Kloc, A. Naeem, J. Ribeiro, A. J. Smith, A. Gonzalez-Cordero and R. R. Ali (2018). "Use of bioreactors for culturing human retinal organoids improves photoreceptor yields." Stem Cell Res Ther 9(1): 156.

2. Gonzalez Cordero, A., D. Goh, K. Kruczek, A. Naeem, M. Fernando, S. M. Kleine Holthaus, M. Takaaki, S. J. I. Blackford, M. Kloc, L. Agundez, R. D. Sampson, S. Borooah, P. Ovando-Roche, M. S. Mehat, E. L. West, A. J. Smith, R. A. Pearson and R. R. Ali (2018). "Assessment of AAV vector tropisms for mouse and human pluripotent stem cell-derived RPE and photoreceptor cells." Hum Gene Ther.

3. Ovando-Roche, P., A. Georgiadis, A. J. Smith, R. A. Pearson and R. R. Ali (2017). "Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration." Curr Stem Cell Rep 3(2): 112-123.

4. Ovando-Roche, P., J. S. Yu, S. Testori, C. Ho and W. Cui (2014). "TRF2-mediated stabilization of hREST4 is critical for the differentiation and maintenance of neural progenitors." Stem Cells 32(8): 2111-2122.
1 Protocol published
Identification of Factors in Regulating a Protein Ubiquitination by Immunoprecipitation: a Case Study of TRF2 on Human REST4 Ubiquitination
Authors:  Wei Cui and Patrick Ovando-Roche, date: 07/05/2015, view: 6920, Q&A: 0
Ubiquitination is the first step of the ubiquitin-proteasome pathway that regulates cells for their homeostatic functions and is an enzymatic, protein post-translational modification process in which ubiquitin is transferred to a target protein ...
5 Protocols reviewed
Papain-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry
Authors:  Hanadie Yousef, Cathrin J Czupalla, Davis Lee, Eugene C Butcher and Tony Wyss-Coray, date: 11/20/2018, view: 2048, Q&A: 0
Brain endothelial cells (BECs) form the integral component of the blood-brain barrier (BBB) which separates the systemic milieu from the brain parenchyma and protects the brain from pathogens and circulating factors. In order to study BEC biology, ...
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Induction of Photothrombotic Stroke in the Sensorimotor Cortex of Rats and Preparation of Tissue for Analysis of Stroke Volume and Topographical Cortical Localization of Ischemic Infarct
Authors:  Anna M. Wiersma and Ian R. Winship, date: 05/20/2018, view: 3346, Q&A: 0
The photothrombotic model of stroke is commonly used in research as it allows the ischemic infarct to be targeted to specific regions of the cortex with high reproducibility and well-defined infarct borders. Unlike other models of stroke, ...
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