Alan Varley Internal Medicine, University of Texas Southwestern Medical School, USA
1 protocol

Mingfang Lu
  • Internal Medicine, University of Texas Southwestern Medical School, USA
Research focus
  • Cell biology
  • 1 Author merit


Ph.D. in Immunology,  UT-Southwestern Medical Center at Dallas, Dallas, TX, 2003

Current Position

Investigator, Department of Immunology, Shanghai Medical College, Fudan University, Shanghai, 200032, China


  1. Huang, Y. L., Morales-Rosado, J., Ray, J., Myers, T. G., Lu, M. and Munford, R. S. Toll-like receptor (TLR) 1/2 and 4 agonists prolong triglyceride retention in macrophages. Submitted
  2. Janelsin, B. M., Myles, I. A., Lu, M. and Datta, S. K. Altered LPS inactivation due to acyloxyacyl hydrolase deficiency in colonic lamina propria dendritic cells impairs mucosal Th17 immunity.Submitted
  3. Lu, M., Varley, A. W. and Munford, R. S. (2013). Persistently active microbial molecules prolong innate immune tolerance in vivo. PLoS Pathog 9(5): e1003339.
  4. Lu, M. and Munford, R. S. (2011). The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo. J Immunol 187(6): 3314-3320.
  5. Munford, R., Lu, M. and Varley, A. (2009). Chapter 2: Kill the bacteria...and also their messengers? Adv Immunol 103: 29-48.
  6. Lu, M., Varley, A. W., Ohta, S., Hardwick, J. and Munford, R. S. (2008). Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection. Cell Host Microbe 4(3): 293-302.
  7. Shao, B., Lu, M., Katz, S. C., Varley, A. W., Hardwick, J., Rogers, T. E., Ojogun, N., Rockey, D. C., Dematteo, R. P. and Munford, R. S. (2007). A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. J Biol Chem 282(18): 13726-13735.
  8. Lu, M., Zhang, M., Takashima, A., Weiss, J., Apicella, M. A., Li, X. H., Yuan, D. and Munford, R. S. (2005). Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria. Nat Immunol 6(10): 989-994.
  9. Feulner, J. A., Lu, M., Shelton, J. M., Zhang, M., Richardson, J. A. and Munford, R. S. (2004). Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract. Infect Immun 72(6): 3171-3178.
  10. Lu, M., Zhang, M., Kitchens, R. L., Fosmire, S., Takashima, A. and Munford, R. S. (2003). Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells. J Exp Med 197(12): 1745-1754.
  11. Lu, M. and Jiang, W. D. (1996).Pharmacokinetics of Imported Nisoldipine in Chinese Healthy Volunteers. Chinese Journal of Clinical Pharmacology. 12:93-98
1 Protocol published
Harvest and Culture of Mouse Peritoneal Macrophages
Authors:  Mingfang Lu and Alan W. Varley, date: 11/20/2013, view: 34444, Q&A: 1
Peritoneal macrophages are used as primary macrophages in lots of studies, mainly because they are easy to obtain. Injection of thioglycollate broth i.p. induces inflammatory responses and elicits large numbers of macrophages. This protocol can be ...
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