Siew-Ging Gong Dentistry University of Toronto
1 protocol

Marcus Cheng Faculty of Dentistry University of Sydney
1 protocol

Delphine Dufour Dental Research Institute, Faculty of Dentistry, University of Toronto, Canada
1 protocol

Céline M. Lévesque
  • Associate Professor, Faculty of Dentistry University of Toronto
Research focus
  • Microbiology
  • 2 Author merit

Education

Ph.D., 2002

Lab information

Levesque Lab
https://www.instagram.com/levesque_lab/

Publications

Since 2015
1. Dufour D, Barbour A, Chan Y, Cheng M, Rahman T, Thorburn M, Stewart C, Finer Y, Gong SG, Lévesque CM. (2020). Genetic analysis of mutacin B-Ny266, a lantibiotic active against caries pathogens. J Bacteriol 202, e00762-19.
2. Bottner A, He RY, Sarbu A, Nainar HSM, Dufour D, Gong SG, Lévesque CM. (2020). Streptococcus mutans isolated from children with severe-early childhood caries form higher levels of persisters. Arch Oral Biol 110, 104601.
3. Ali IAA, Cheung BPK, Matinlinna JP, Lévesque CM, Neelakantan P. (2020). Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery. Microb Pathog 149:104482.
4. Balasubramanian AR, Vasudevan S, Shanmugam K, Lévesque CM, Solomon AP, Neelakantan P. (2020). Combinatorial effects of trans-cinnamaldehyde with fluoride and chlorhexidine on Streptococcus mutans. J Appl Microbiol 2020 July 24. doi:10.1111/jam.14794.
5. Ko-Adams C, Cioffi I, Dufour D, Nainar H, Lévesque CM, Gong SG. (2020). Short term effects of fixed orthodontic appliance on concentrations of mutans streptococci and persister cells in adolescents. Am J Orthod Dentofacial Orthop 157, 385-391.
6. Lamba GS, Dufour D, Nainar SMH, Cioffi I, Lévesque CM, Gong SG. (2020). Association of Streptococcus mutans collagen binding genes with severe childhood caries. Clin Oral Investig Jan 30. doi: 10.1007/s00784-020-03217-4.
7. Ali IAA, Cheung BPK, Yau JYY, Matinlinna JP, Lévesque CM, Belibasakis GN, Neelakantan P. (2020). The influence of substrate surface conditioning and biofilm age on the composition of Enterococcus faecalis biofilms. Int Endod J 53, 53-61.
8. Gong SG, Chan Y, Lévesque CM. (2019). Complete genome sequence of megaplasmid-bearing Streptococcus salivarius strain LAB813, isolated from the dental plaque of a caries-free child. Microbiol Resour Announc 8, e01092-19.
9. Marashdeh MQ, Friedman S, Lévesque C, Finer Y. (2019). Esterases affect the physical properties of materials used to seal the endodontic space. Dent Mater 35, 1065-1072.
10. Barbour A, He RY, Gong SG, Lévesque CM. (2019). Complete genome sequence of Streptococcus mutans LAB761, which harbors several bacteriocin loci, isolated from a caries-active child in Canada. Microbiol Resour Announc 8, e01483-18.
11. Marashdeh M, Gitalis R, Lévesque CM, Finer Y. (2019). Endodontic pathogens possess collagenolytic properties that degrade human dentin collagen matrix. Int Endod J 52, 416-423.
12. Dufour D, Mankovskaia A, Chan Y, Motavaze K, Gong SG, Lévesque CM. (2018). A tripartite toxin-antitoxin module induced by quorum sensing is associated with the persistence phenotype in Streptococcus mutans. Mol Oral Microbiol 33, 420-429.
13. Stavroullakis AT, Carrilho MR, Lévesque CM, Prakki A. (2018). Profiling cytokine levels in chlorhexidine and EGCG-treated odontoblast-like cells. Dent Mater 34, e107-e114.
14. Marashdeh M, Gitalis R, Lévesque C, Finer Y. (2018). Enterococcus faecalis hydrolyses dental resin composites and adhesives. J Endo 44, 609-613.
15. Dufour D, Villemin C, Perry JA, Lévesque CM. (2016). Escape from the competence state in Streptococcus mutans is governed by the bacterial population density. Mol Oral Microbiol 31, 501-514.
16. Sima C, Cheng Q, Rautava J, Lévesque CM, Sherman P, Glogauer M. (2016). Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis. J Periodontol Res 51, 237-249.
17. Marashdeh M, Lévesque CM, Friedman S, Finer Y. (2016). Sealer type and esterases affect interfacial Enterococcus faecalis biofilm proliferation in root canals. J Endo 42, e22.
18. Leung V, Dufour D, Lévesque CM. (2015). Death and survival in Streptococcus mutans: differing outcomes of a quorum-sensing signaling peptide. Front Microbiol 6, article 1176.
19. Singh K, Senadheera DB, Lévesque CM, Cvitkovitch DG. (2015). The copYAZ operon functions in copper efflux, biofilm formation, genetic transformation and stress tolerance in Sreptococcus mutans. J Bacteriol 197, 2545-2557.
20. Leung V, Ajdic D, Koyanagi S, Lévesque CM. (2015). The formation of Streptococcus mutans persisters induced by the quorum-sensing peptide pheromone is affected by the LexA regulator. J Bacteriol 197, 1083-1094.
2 Protocols published
Rapid Isolation and Purification of Secreted Bacteriocins from Streptococcus mutans and Other Lactic Acid Bacteria
Authors:  Marcus Cheng, Siew-Ging Gong and Céline M. Lévesque, date: 11/20/2020, view: 600, Q&A: 0
Bacteriocins are small ribosomally synthesized antimicrobial peptides produced by some microorganisms including lactic acid bacteria (LAB), a group of Gram-positive bacteria (cocci, rods) expressing high tolerance for low pH. Bacteriocins kill ...
Zymogram Assay for the Detection of Peptidoglycan Hydrolases in Streptococcus mutans
Authors:  Delphine Dufour and Céline M. Lévesque, date: 08/20/2013, view: 11606, Q&A: 1
Peptidoglycan hydrolases or autolysins are enzymes capable of cleaving covalent bonds in bacterial peptidoglycan cell wall layer. They can participate in the cell division process, in the release of turnover products from peptidoglycan during cell ...
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