Sophia Maschalidi INSERM, Unité 1013, France
1 protocol

Bénédicte Manoury
  • INSERM, Unité 1013, France
Research focus
  • Immunology
  • 2 Author merit


Ph.D. in Immunology, Université René Descartes Paris V, 1996

Current position

DR2 (CNRS), U1013, Hopital Necker, Paris, France

Publications (since 2005)

  1. Tohme, M., Maschalidi, S. and Manoury, B. (2013). In vitro digestion with proteases producing MHC class II ligands. Methods Mol Biol 960: 509-515.
  2. Maschalidi, S., Hassler, S., Blanc, F., Sepulveda, F. E., Tohme, M., Chignard, M., van Endert, P., Si-Tahar, M., Descamps, D. and Manoury, B. (2012). Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation. PLoS Pathog 8(8): e1002841.
  3. Apcher, S., Manoury, B. and Fahraeus, R. (2012). The role of mRNA translation in direct MHC class I antigen presentation. Curr Opin Immunol 24(1): 71-76.
  4. Weimershaus, M., Maschalidi, S., Sepulveda, F., Manoury, B., van Endert, P. and Saveanu, L. (2012). Conventional dendritic cells require IRAP-Rab14 endosomes for efficient cross-presentation. J Immunol 188(4): 1840-1846.
  5. Descamps, D., Le Gars, M., Balloy, V., Barbier, D., Maschalidi, S., Tohme, M., Chignard, M., Ramphal, R., Manoury, B. and Sallenave, J. M. (2012). Toll-like receptor 5 (TLR5), IL-1beta secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing. Proc Natl Acad Sci U S A 109(5): 1619-1624.
  6. Guery, L., Benikhlef, N., Gautier, T., Paul, C., Jego, G., Dufour, E., Jacquel, A., Cally, R., Manoury, B., Vanden Berghe, T., Vandenabeele, P., Droin, N. and Solary, E. (2011). Fine-tuning nucleophosmin in macrophage differentiation and activation. Blood 118(17): 4694-4704.
  7. Manoury, B. (2011). TLR9 regulation by proteolysis: a friend or a foe. Eur J Immunol 41(8): 2142-2144.
  8. Apcher, S., Daskalogianni, C., Lejeune, F., Manoury, B., Imhoos, G., Heslop, L. and Fahraeus, R. (2011). Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation. Proc Natl Acad Sci U S A 108(28): 11572-11577.
  9. Apcher, S., Daskalogianni, C., Manoury, B. and Fahraeus, R. (2010). Epstein Barr virus-encoded EBNA1 interference with MHC class I antigen presentation reveals a close correlation between mRNA translation initiation and antigen presentation. PLoS Pathog 6(10): e1001151.
  10. Sepulveda, F. E., Maschalidi, S., Colisson, R., Heslop, L., Ghirelli, C., Sakka, E., Lennon-Dumenil, A. M., Amigorena, S., Cabanie, L. and Manoury, B. (2009). Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity 31(5): 737-748.
  11. Le Roux, D., Lankar, D., Yuseff, M. I., Vascotto, F., Yokozeki, T., Faure-Andre, G., Mougneau, E., Glaichenhaus, N., Manoury, B., Bonnerot, C. and Lennon-Dumenil, A. M. (2007). Syk-dependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptor. Mol Biol Cell 18(9): 3451-3462.
  12. Vascotto, F., Lankar, D., Faure-Andre, G., Vargas, P., Diaz, J., Le Roux, D., Yuseff, M. I., Sibarita, J. B., Boes, M., Raposo, G., Mougneau, E., Glaichenhaus, N., Bonnerot, C., Manoury, B. and Lennon-Dumenil, A. M. (2007). The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation. J Cell Biol 176(7): 1007-1019.
  13. Watts, C., Matthews, S. P., Mazzeo, D., Manoury, B. and Moss, C. X. (2005). Asparaginyl endopeptidase: case history of a class II MHC compartment protease. Immunol Rev 207: 218-228.
  14. Murray, J., Manoury, B., Balic, A., Watts, C. and Maizels, R. M. (2005). Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Mol Biochem Parasitol 139(2): 197-203.
2 Protocols published
Isolation of Phagosomes from Dendritic Cells by Using Magnetic Beads
Author:  Bénédicte Manoury, date: 07/20/2013, view: 8620, Q&A: 1
Phagosomes are intracellular organelles in dendritic cells in which pathogens such as viruses, bacteria and parasites are internalised to be proteolysed and killed. Phagosomes are formed by fusion with the plasma membrane, some area of the ...
Endosomal pH Measurement in Bone Marrow Derived Dendritic Cells
Authors:  Sophia Maschalidi and Bénédicte Manoury, date: 07/20/2013, view: 7875, Q&A: 0
Endosomes embraces different set of compartments such as early endosomes, intermediate endosomes and late endosomes or lysosomes. They become acidic as they mature. This acidification is generated by the vacuolar membrane proton pump V-ATPase that ...
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