Education

PhD, University of Virginia, United States, 1997

Current position

Associate Professor, Department of Molecular Neuroscience, George Mason University, United States

Publications (since 1995)

1. Sanders, E.M., Nyarko-Odoom, A.O., Zhou, K.C., Nguyen, M.A., Liao, H.H., Keith, M., Pyon, J., Kozma, A., Sanyal, M., McHail, D.G., Dumas T.C. (2018) Separate functional properties of NMDARs regulate distinct aspects of spatial cognition. Learn. Mem. In press.

2. McHail, D.G., Valibeigi, N., Dumas, T.C. (2018) Barnes maze for juvenile rats delineates the emergence of spatial navigation ability. Learn. Mem. 25(3):138-146.

3. Stoneham ET, McHail DG, Boggs KN, Albani SH, Carty JA, Evans RC, Hamilton KA, Saadat VM, Hussain S, Greer ME, Dumas TC. (2017) Functional perturbation of forebrain principal neurons reveals differential effects in novel and well-learned tasks. Brain Res. 1671:1-13.

4. Simon DM, Charkhkar H, St John C, Rajendran S, Kang T, Reit R, Arreaga-Salas D, McHail DG, Knaack GL, Sloan A, Grasse D, Dumas TC, Rennaker RL, Pancrazio JJ, Voit WE. (2017) Design and demonstration of an intracortical probe technology with tunable modulus. J. Biomed. Mater. Res. A. 105(1):159-168.

5. Knaack, G.L., McHail, D.G., Borda, G., Beom, S.K., Peixoto, N., Cogan, S.F., Dumas, T.C., Pancrazio, J.J. (2016) In vivo Characterization of Amorphous Silicon Carbide as a Biomaterial for Chronic Neural Interfaces. Front. Neurosci. Neural Tech. 10:301.

6. Gardner, R.S., Uttaro, M.R., Fleming, S.E., Suarez, D.F., Ascoli, G.A., Dumas, T.C. (2016) Differential Arc expression in the hippocampus and striatum during the transition from attentive to automatic navigation on a plus maze. Neurobiol. Learn. Mem. 131:36-45.

7. Charkhkar, H., Knaack, G.L., McHail, D.G., Mandal, H.S., Peixoto, N., Rubinson, J.F., Dumas, T.C., Pancrazio, J.J. (2016) Chronic intracortical neural recordings using microelectrode arrays coated with PEDOT-TFB. Acta Biomaterialia. 32:57-67.

8. Hawes, S.L., Evans, R.C., Unruh, B.A., Benkert, E.E., Gillani, F., Dumas, T.C., Blackwell, K.T. (2015) Multimodal Plasticity in Dorsal Striatum While Learning a Lateralized Navigation Task. J. Neurosci. 35(29):10535-49.

9. Albani, S.H., Andrawis, M.M, Abella, R.J., Fulghum, J., Vafamand, N., Dumas, T.C. (2015) Behavior in the elevated plus maze is differentially affected by testing conditions in rats under and over three weeks of age. Frontiers in Behavioral Neuroscience. 9:31.

10. Mandal, H.S., Kastee, J., McHail, D.G., Rubinson, J.F., Pancrazio, J.J., Dumas, T.C. (2015) Improved Poly(3,4-ethylenedioxythiophene) (PEDOT) for neural stimulation. Neuromodulation. 18(8):657-63.

11. McHail, D.G., Dumas, T.C. (2015) Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development. Dev Cogn Neuroscience, 2015 Apr;12:145-54

12. Mandal HS, Kastee JS, McHail DG, Rubinson JF, Pancrazio JJ, Dumas TC. Improved Poly(3,4-Ethylenedioxythiophene) (PEDOT) for Neural Stimulation. Neuromodulation, 2015 Mar 21. doi: 10.1111/ner.12285 

13. Albani, S.H.*, McHail, D.G.*, & Dumas, T.C. Developmental studies of the hippocampus and hippocampal-dependent behaviors: Insights from interdisciplinary studies and tips for new investigators. (*authors contributed equally)Neuroscience and Biobehavioral Reviews, In press 

14. Mandal, H.S., Knaack, G.L., Charkhkar, H., McHail, D.G., Kastee, J., Dumas, T.C., Peixoto, N., Rubinson, J.F., & Pancrazio, J.J. Improving the performance of poly (3,4-ethylenedioxythiophene) (PEDOT) for brain machine interface applications. Acta Biomaterialia, In press

15. Gardner, R.S., Uttaro, M., Fleming, S.E., Suarez, D.F., Ascoli,G.A., & Dumas, T.C. (2013) Secondary spatial working memory preserves primary place strategies despite over-training. Learning and Memory, 2013 Oct 17; 20(11): 648-656

16. Blair, M,. Nguyen, N., Albani, S., L'Etoile, M., Andrawis, M., Owen, L., Oliveira, R., Johnson, M., Purvis, D., Sanders, E., Stoneham, E., Xu, H., & Dumas, T.C. (2013) Developmental changes in structural and functional properties of hippocampal AMPA receptors parallels the emergence of deliberative spatial navigation in juvenile rats. Journal of Neuroscience, 2013 Jul 24; 33(30): 12218-12228

17. Sanders, E.M., Nguyen, M.A., Zhou, K.C., Hanks, M E., Yusuf, K A., Cox, D.N., & Dumas, T C. (2013) Developmental modification of synaptic NMDAR composition and maturation of glutamatergic synapses: matching postsynaptic slots with receptor pegs. Biological Bulletin, 224(1): 1-13

18. Dumas, T.C. (2012) Postnatal alterations in induction threshold and expression magnitude of long-term potentiation and long-term depression at hippocampal synapses. Hippocampus, 22: 188-99 

19. Stoneham, E.T., Sanders, E.M., Sanyal, M., & Dumas, T.C. (2010) Rules of engagement: Factors that regulate activity dependent synaptic plasticity during neural network development. Biological Bulletin, 219: 81-99

20. Dumas, T.C., Gillette, T., Ferguson, D., Hamilton, K. & Sapolsky, R.M. (2010) Anti-glucocorticoid gene therapy reverses the impairing effects of elevated corticosterone on spatial memory, hippocampal neuronal excitability, and synaptic plasticity. Journal of Neuroscience, 30: 1712-1720

21. Dumas, T.C. (2005a) Late postnatal maturation of excitatory synaptic transmission permits the expression of adult-like hippocampal-dependent behaviors. Hippocampus, 15: 562-578

22. Dumas, T.C. (2005b) Developmental regulation of cognitive abilities: Modified composition of a molecular switch turns on associative learning. Progress in Neurobiology, 76: 189-211

23. Xie, X., Dumas, T., Tang, L., Brennan, T., Reeder, T., Winston, T., Klein, R.D., Flores, J., O'Hara, B.F., Heller, H.C., & Franken, P. (2005) Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Research, 1052: 212-221

24. Nair, S., Karst, H., Dumas, T., Phillips, R., Sapolsky, R., Rumpff-van Essen, L., Maslam, S., Lucassen, P., & Joels, M. (2004) Gene expression profiles associated with survival of individual rat dentate cells after endogenous corticosteroid deprivation. European Journal of Neuroscience, 20: 3233-3243

25. Kaufer, D., Ogle, W.O., Pincus, Z.S., Clark, K., Nicholas A.C., Dinkel, K.M., Dumas, T.C., Ferguson, D., Lee, A.L., Winters, M. & Sapolsky, R.M. (2004) Restructuring the neuronal stress response with anti-glucocorticoid gene delivery. Nature Neuroscience, 7: 947-953 

26. Dumas, T.C., Powers, E.C., Tarapore, P.E. & Sapolsky, R.M. (2004) Overexpression of calbindin D(28k) in dentate granule cells potentiates mossy fiber presynaptic function, reduces long-term potentiation and impairs hippocampal-dependent memory. Hippocampus, 14: 701-709

27. Dumas, T.C. (2004) Early eyelid opening enhances spontaneous alternation and accelerates the development of perforant path synaptic strength in the hippocampus of juvenile rats. Developmental Psychobiology, 45: 1-9

28. Lee, A.L., Dumas, T.C., Tarapore, P.E., Webster, B.R., Ho, D.Y., Kaufer, D. & Sapolsky, R.M. (2003) Potassium channel gene therapy can prevent neuron death resulting from necrotic insults. Journal of Neurochemistry, 86: 1079-88 

29. Dumas, T.C. & Sapolsky, R.M. (2001) Gene therapy against neurological insults: sparing neurons versus sparing function. Trends in Neuroscience, 24: 695-700

30. Foster, T.C. & Dumas, T.C. (2001) Mechanism for increased hippocampal synaptic strength following differential experience. Journal of Neurophysiology, 85: 1377-1383 

31. Yenari, M.A., Dumas, T.C., Sapolsky, R.M. & Steinberg, G.K., (2000) Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors. Neurology Research, 23: 543-552

32. Yenari, M.A., Dumas, T.C., Sapolsky, R.M. & Steinberg, G.K., (2000) Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors. In Slikker W & Trembly B (Eds), Neuroprotective Agents: 5th International Conference, Annals of the New York Acadamy of Sciences, 939: 340-357

33. McLaughlin, J.R., Roozendaal, B., Dumas, T.C., Gupta, A., Ajilore, O., Hsieh, J., Ho, D.Y., Lawrence, M.S., McGaugh, J.L. & Sapolsky, R.M. (2000) Sparing neuronal function post-seizure with gene therapy. Proceedings of the National Academy of Sciences (USA), 97: 12804-12809 

34. Dumas, T.C., McLaughlin, J.R., Ho, D.Y., Lawrence, M.S. & Sapolsky, R.M. (2000) Gene therapies that enhance hippocampal neuron survival after an excitotoxic insult are not equivalent in their ability to maintain synaptic transmission. Experimental Neurology, 166: 180-189

35. Dumas, T.C., McLaughlin, J.R., Ho, D.Y., Meier, T.J. & Sapolsky, R.M. (1999) Delivery of herpes simplex virus amplicon-based vectors to the dentate gyrus does not alter hippocampal synaptic transmission in vivo. Gene Therapy, 6: 1679-1684

36. Dumas, T.C. & Foster, T.C. (1998) GABA(b) receptors differentially regulate hippocampal CA1 excitatory synaptic transmission across postnatal development in the rat. Neuroscience Letters, 248: 138-140

37. Dumas, T.C. & Foster, T.C. (1998) Late developmental changes in the ability of adenosine A1 receptors to regulate synaptic transmission in the hippocampus. Developmental Brain Research, 105: 137-139

38. Dumas, T.C. & Foster, T.C. (1997) Development of metabotropic glutamate receptor-mediated synaptic inhibition. NeuroReport, 8: 2919-2924

39. Dumas, T.C. & Foster, T.C. (1995) Developmental increase in CA3-CA1 presynaptic function in the hippocampal slice. Journal of Neurophysiology, 73: 1821-1828

    Chapters:
    Dumas, T.C. & Rudy, J.W. (2010) Development of the hippocampal memory system: Creating networks and modifiable synapses. In Oxford Handbook of Developmental and Behavioral Neuroscience. Oxford University Press, Invited chapter, p. 587-606
    Yenari, M.A., Dumas, T.C., Sapolsky, R.M. & Steinberg, G.K., (2000) The role of gene therapy in acute cerebral ischemia. In J. Krieglstein & S. Klumpp (Eds), Pharmacology of Cerebral Ischemia, Medpharm Scientific Publishers, Stuttgart, p. 457-472