Education

Ph.D. in Biochemistry, University of California, Davis, 1983

Current position

Professor, Department of Toxicology, Markey Cancer Center, University of Kentucky (2013-present)
Director, Center for Environmental and Systems Biochemistry (2013-present)
Edith D. Gardner Chair in Cancer Research (2013-present)

Publications

1. Sellers, K., Fox, M. P., Bousamra, M., 2nd, Slone, S. P., Higashi, R. M., Miller, D. M., Wang, Y., Yan, J., Yuneva, M. O., Deshpande, R., Lane, A. N. and Fan, T. W. (2015). Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest 125(2): 687-698.
   
2. Guin, S., Pollard, C., Ru, Y., Ritterson Lew, C., Duex, J. E., Dancik, G., Owens, C., Spencer, A., Knight, S., Holemon, H., Gupta, S., Hansel, D., Hellerstein, M., Lorkiewicz, P., Lane, A. N., Fan, T. W. and Theodorescu, D. (2014). Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease. J Natl Cancer Inst 106(5).
   
3. Xie, H., Hanai, J., Ren, J. G., Kats, L., Burgess, K., Bhargava, P., Signoretti, S., Billiard, J., Duffy, K. J., Grant, A., Wang, X., Lorkiewicz, P. K., Schatzman, S., Bousamra, M., 2nd, Lane, A. N., Higashi, R. M., Fan, T. W., Pandolfi, P. P., Sukhatme, V. P. and Seth, P. (2014). Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell Metab 19(5): 795-809.
   
4. Dong, C., Yuan, T., Wu, Y., Wang, Y., Fan, T. W., Miriyala, S., Lin, Y., Yao, J., Shi, J., Kang, T., Lorkiewicz, P., St Clair, D., Hung, M. C., Evers, B. M. and Zhou, B. P. (2013). Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell 23(3): 316-331.
   
5. Fan, T. W., Lorkiewicz, P. K., Sellers, K., Moseley, H. N., Higashi, R. M. and Lane, A. N. (2012). Stable isotope-resolved metabolomics and applications for drug development. Pharmacol Ther 133(3): 366-391.
   
6. Yuneva, M. O., Fan, T. W., Allen, T. D., Higashi, R. M., Ferraris, D. V., Tsukamoto, T., Mates, J. M., Alonso, F. J., Wang, C., Seo, Y., Chen, X. and Bishop, J. M. (2012). The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab 15(2): 157-170.
   
7. Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., Zimmerman, L. J., Liebler, D. C., Slebos, R. J., Lorkiewicz, P. K., Higashi, R. M., Fan, T. W. and Dang, C. V. (2012). Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 15(1): 110-121.
   
8. Fan, T. W. (2012). Metabolomics-Edited Transcriptomics Analysis (META). In: Fan, T. W., Lane, A. N. and Higashi, R. M. (eds). The Handbook of Metabolomics: Pathway and Flux Analysis, Methods in Pharmacology and Toxicology. Springer Science 17: 439-480.
   
9. Liu, W., Le, A., Hancock, C., Lane, A. N., Dang, C. V., Fan, T. W. and Phang, J. M. (2012). Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci U S A 109(23): 8983-8988.
   
10. Fan, T. W., Lane, A. N., Higashi, R. M. and Yan, J. (2011). Stable isotope resolved metabolomics of lung cancer in a SCID mouse model. Metabolomics 7(2): 257-269.
    
11. Moseley, H. N., Lane, A. N., Belshoff, A. C., Higashi, R. M. and Fan, T. W. (2011). A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on (13)C mass isotopologue profiles under non-steady-state conditions. BMC Biol 9: 37.
    
12. Fan, T. W., Yuan, P., Lane, A. N., Higashi, R. M., Wang, Y., Hamidi, A. B., Zhou, R., Guitart, X., Chen, G., Manji, H. K. and Kaddurah-Daouk, R. (2010). Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions. Metabolomics 6(2): 165-179.
    
13. Lane, A. N., Fan, T. W., Xie, Z., Moseley, H. N. and Higashi, R. M. (2009). Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR. Anal Chim Acta 651(2): 201-208.
    
14. Fan, T. W., Lane, A. N., Higashi, R. M., Farag, M. A., Gao, H., Bousamra, M. and Miller, D. M. (2009). Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 8: 41.
    
15. Fan, T. W., Higashi, R. M. and Lane, A. N. (2006). Integrating metabolomics and transcriptomics for probing SE anticancer mechanisms. Drug Metab Rev 38(4): 707-732.
    
16. Fan, T., Bandura, L., Higashi, R. and Lane, A. (2005). Metabolomics-edited transcriptomics analysis of Se anticancer action in human lung cancer cells. Metabolomics 1(4):325-339.