Education

Ph.D. in Molecular Biology, University of Montreal, Montréal, Canada, 2006

Current position

Assistant Professor, University of Ottawa, Ottawa, Canada (08/2015-present)

Publications

Peer reviewed publications

1. Campbell-Valois, F. X.* and Pontier, S. M. (2016). Implications of Spatiotemporal Regulation of Shigella flexneri Type Three Secretion Activity on Effector Functions: Think Globally, Act Locally. Front Cell Infect Microbiol 6: 28. (*Corresponding author)
   
2. Arena, E. T.^†, Campbell-Valois, F. X.^†, Tinevez, J. Y.^†, Nigro, G.^†, Sachse, M., Moya-Nilges, M., Nothelfer, K., Marteyn, B., Shorte, S. L. and Sansonetti, P. J. (2015). Bioimage analysis of Shigella infection reveals targeting of colonic crypts. Proc Natl Acad Sci U S A 112(25): E3282-3290. (^†Equal contributions)
   
3. Campbell-Valois, F. X.*, Sachse, M., Sansonetti, P. J. and Parsot, C. (2015). Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA. MBio 6(3): e02567-02514. (*Corresponding author)
   
4. Campbell-Valois, F. X.*, Schnupf, P., Sansonetti P. J. (2014). Design of a Transcription-based Secretion Activity Reporter (TSAR) for the Type III secretion apparatus of S. flexneri and uses thereof. Bio-protocol 4(20): e1270. (*Corresponding author)
   
5. Campbell-Valois, F. X.*, Schnupf, P. and Sansonetti, P. J. (2014). Detection of the Secreted and Cytoplasmic Fractions of IpaB, IpaC and IpaD by Lysozyme Permeabilization. Bio-protocol 4(20): e1271. (*Corresponding author)
   
6. Campbell-Valois, F.X. and Sansonetti, P.J. (2014). Tracking Bacterial Pathogen infection with geneticallyencoded reporters, FEBS Letters 2014 Aug 1;588(15):2428-36.
   
7. Grishin, A. M., Condos, T. E., Barber, K. R., Campbell-Valois, F. X., Parsot, C., Shaw, G. S. and Cygler, M. (2014). Structural basis for the inhibition of host protein ubiquitination by Shigella effector kinase OspG. Structure 22(6): 878-888.
   
8. Campbell-Valois, F. X.*, Schnupf, P., Nigro, G., Sachse, M., Sansonetti, P. J. and Parsot, C. (2014). A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread. Cell Host Microbe 15(2): 177-189. (*Corresponding author)
   
9. Campbell-Valois, F. X.* ^†, Trost, M.* ^†, Chemali, M., Dill, B. D., Laplante, A., Duclos, S., Sadeghi, S., Rondeau, C., Morrow, I. C., Bell, C., Gagnon, E., Hatsuzawa, K., Thibault, P. and Desjardins, M. (2012). Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Mol Cell Proteomics 11(7): M111 016378. (*Corresponding authors; ^†Equal contribution)
   
10. Remy, I., Campbell-Valois, F. X. and Michnick, S. W. (2007). Detection of protein-protein interactions using a simple survival protein-fragment complementation assay based on the enzyme dihydrofolate reductase. Nat Protoc 2(9): 2120-2125.
    
11. Campbell-Valois, F. X. and Michnick, S. W. (2007). The transition state of the ras binding domain of Raf is structurally polarized based on φ-values but is energetically diffuse. J Mol Biol 365(5): 1559-1577.
    
12. Campbell-Valois, F. X. and Michnick, S. W. (2007). Synthesis of degenerated libraries of the ras-binding domain of raf and rapid selection of fast-folding and stable clones with the dihydrofolate reductase protein fragment complementation assay. Methods Mol Biol 352: 249-274.
    
13. Campbell-Valois, F. X., Tarassov, K. and Michnick, S. W. (2006). Massive sequence perturbation of the Raf ras binding domain reveals relationships between sequence conservation, secondary structure propensity, hydrophobic core organization and stability. J Mol Biol 362(1): 151-171.
    
14. Campbell-Valois, F. X., Tarassov, K. and Michnick, S. W. (2005). Massive sequence perturbation of a small protein. Proc Natl Acad Sci U S A 102(42): 14988-14993.
    
15. Campbell-Valois, F. X. and Michnick, S. (2005). Chemical biology on PINs and NeeDLes. Curr Opin Chem Biol 9(1): 31-37.
    
16. Michnick, S. W. and Valois, F. X. (2002). Gene function: getting specific, generally speaking. Proc Natl Acad Sci U S A 99(26): 16513-16515.
    
17. Michnick, S. W., Remy, I., Campbell-Valois, F. X., Vallee-Belisle, A. and Pelletier, J. N. (2000). Detection of protein-protein interactions by protein fragment complementation strategies. Methods Enzymol 328: 208-230.
    
18. Pelletier, J. N., Campbell-Valois, F. X. and Michnick, S. W. (1998). Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments. Proc Natl Acad Sci U S A 95(21): 12141-12146.
    

Books or book chapters

1. Campbell-Valois, F. X. (2014). Folding of the polypeptide sequence of small proteins (French). Presses Académiques Francophones.
   
2. Remy, I., Campbell-Valois, F. X., Aquin, S., Ghaddar, G. and Michnick, S. W. (2005). Detection of protein interactions and library screening with protein fragment complementation strategies. Molecular Biology Protocols Protein-protein interactions, second edition, Chapitre 33, pp. 637-671.