Education
PhD, Tel-Aviv University, 2005
Lab information
The primary emphasis of my Lab is to understand how Alzheimer's disease operates — from the mechanism of damage to repair. Major efforts are in developing early diagnostic strategies and disease-modifying therapies. Research projects included in our study:
• Disease in the Eye’s retina
• Retinal biomarker imaging: can Alzheimer’s be detected noninvasively and definitively with retinal imaging?
• Visual deficits in animal models of aging and AD
• Disease pathogenesis in the brain, retina and body fluids:
o Neuro-immune interactions
o Neurovascular unit
o Infectious etiology
o Epigenome mechanisms and related interventions
• Immune-based therapies
• Blood monocytes in repair and regeneration of central nervous system and cognitive preservation
• Enhancing angiotensin-converting enzyme in immune cells
• Other strategies to preserve brain cells, structure, and connectivity, protecting from cognitive decline
https://www.cedars-sinai.edu/research/labs/koronyo-hamaoui.html
Research focus
Neuro-ophthalmology, Neuroimmunology, Alzheimer's disease.
A major focus of Dr. Koronyo-Hamaoui’s research is investigating the role of innate immune cells – especially peripheral monocytes and macrophages – in CNS repair and regeneration, and the development of immunomodulation-based treatments for Alzheimer’s disease (AD). In addition, she is exploring the pathological changes in the retina specific to AD for the prospect of early screening and tracking response to therapy.
Her team is a pioneer in identifying the pathological hallmark of AD, Aβ plaques, in the retina of AD patients, including early-stage cases. Her group together with Neurovision Imaging LLC further developed a breakthrough noninvasive approach for detection of retinal Aβ deposits in living patients using high-resolution optical retinal imaging. Currently, her lab is probing neuroinflammation, tauopathy, degeneration, and vascular biomarkers in the retina of MCI and AD patients while establishing their relationship with disease in the brain.
Publications