Education

Ph.D. in Medical Science, Osaka University, 1979

Current Position

Professor in Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Publications (since 2010)

1. Yamashita, A., Kawashita, N., Li, YG, Sasaki, T., Tao, R., Yang, P., Ramasoota, P., and Ikuta, K.: Human neutralizing epitope in the envelope domain II of dengue virus recognizing by dengue patients shows dynamic conformational change after fusion process. Future Virology, in press.
   
2. Yasugi, M., Kubota-Koketsu, R., Yamashita, A., Kawashita, N., Du, A., Misaki, R., Kuhara, M., Boonsathorn, N., Fujiyama, K., Okuno, Y., Nakaya, T. and Ikuta, K. (2013). Emerging antigenic variants at the antigenic site Sb in pandemic A(H1N1)2009 influenza virus in Japan detected by a human monoclonal antibody. PLoS One 8(10): e77892.
   
3. Wangroongsarb, P., Kohda, T., Jittaprasartsin, C., Suthivarakom, K., Kamthalang, T., Umeda, K., Sawanpanyalert, P., Kozaki, S., and Ikuta, K.: Molecular characterization of Clostridium botulinum isolates from Foodborne Outbreaks in Thailand, 2010. PLoS One, in press.
   
4. Sasaki, T., Setthapramote, C., Kurosu, T., Nishimura, M., Asai, A., Omokoko, M. D., Pipattanaboon, C., Pitaksajjakul, P., Limkittikul, K., Subchareon, A., Chaichana, P., Okabayashi, T., Hirai, I., Leaungwutiwong, P., Misaki, R., Fujiyama, K., Ono, K., Okuno, Y., Ramasoota, P. and Ikuta, K. (2013). Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection. Antiviral Res 98(3): 423-431.
   
5. Watanabe, Y., Ibrahim, M. S. and Ikuta, K. (2013). Evolution and control of H5N1. A better understanding of the evolution and diversity of H5N1 flu virus and its host species in endemic areas could inform more efficient vaccination and control strategies. EMBO Rep 14(2): 117-122.
   
6. Inoue, Y., Kubota-Koketsu, R., Yamashita, A., Nishimura, M., Ideno, S., Ono, K., Okuno, Y. and Ikuta, K. (2013). Induction of anti-influenza immunity by modified green fluorescent protein (GFP) carrying hemagglutinin-derived epitope structure. J Biol Chem 288(7): 4981-4990.
   
7. Yasugi, M., Kubota-Koketsu, R., Yamashita, A., Kawashita, N., Du, A., Sasaki, T., Nishimura, M., Misaki, R., Kuhara, M., Boonsathorn, N., Fujiyama, K., Okuno, Y., Nakaya, T. and Ikuta, K. (2013). Human monoclonal antibodies broadly neutralizing against influenza B virus. PLoS Pathog 9(2): e1003150.
   
8. Sasaki, T., Kubota-Koketsu, R., Takei, M., Hagihara, T., Iwamoto, S., Murao, T., Sawami, K., Fukae, D., Nakamura, M., Nagata, E., Kawakami, A., Mitsubayashi, Y., Ohno, M., Uehara, Y., Fukukawa, T., Kanai, Y., Kosaka, M. and Ikuta, K. (2012). Reliability of a newly-developed immunochromatography diagnostic kit for pandemic influenza A/H1N1pdm virus: implications for drug administration. PLoS One 7(11): e50670.
   
9. Watanabe, Y., Ibrahim, M. S., Suzuki, Y. and Ikuta, K. (2012). The changing nature of avian influenza A virus (H5N1). Trends Microbiol 20(1): 11-20.
   
10. Watanabe, Y., Ibrahim, M. S., Ellakany, H. F., Kawashita, N., Daidoji, T., Takagi, T., Yasunaga, T., Nakaya, T. and Ikuta, K. (2012). Antigenic analysis of highly pathogenic avian influenza virus H5N1 sublineages co-circulating in Egypt. J Gen Virol 93(Pt 10): 2215-2226.
    
11. Matsumoto, Y., Hayashi, Y., Omori, H., Honda, T., Daito, T., Horie, M., Ikuta, K., Fujino, K., Nakamura, S., Schneider, U., Chase, G., Yoshimori, T., Schwemmle, M. and Tomonaga, K. (2012). Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection. Cell Host Microbe 11(5): 492-503.
    
12. Yasugi, M., Nakamura, S., Daidoji, T., Kawashita, N., Ramadhany, R., Yang, C. S., Yasunaga, T., Iida, T., Horii, T., Ikuta, K., Takahashi, K. and Nakaya, T. (2012). Frequency of D222G and Q223R hemagglutinin mutants of pandemic (H1N1) 2009 influenza virus in Japan between 2009 and 2010. PLoS One 7(2): e30946.
    
13. Boonchawalit, S., Jullaksorn, D., Uttiyoung, J., Yowang, A., Krathong, N., Chautrakul, S., Yamashita, A., Ikuta, K., Roobsoong, A., Kanitvittaya, S., Sawanpanyalert, P. and Kameoka, M. (2011). Molecular evolution of HIV-1 CRF01_AE Env in Thai patients. PLoS One 6(11): e27098.
    
14. Watanabe, Y., Ibrahim, M. S., Ellakany, H. F., Abd El-Hamid, H. S. and Ikuta, K. (2011). Genetic diversification of H5N1 highly pathogenic avian influenza A virus during replication in wild ducks. J Gen Virol 92(Pt 9): 2105-2110.
    
15. Watanabe, Y., Ibrahim, M. S., Ellakany, H. F., Kawashita, N., Mizuike, R., Hiramatsu, H., Sriwilaijaroen, N., Takagi, T., Suzuki, Y. and Ikuta, K. (2011). Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt. PLoS Pathog 7(5): e1002068.
    
16. Mizuike, R., Sasaki, T., Baba, K., Iwamoto, H., Shibai, Y., Kosaka, M., Kubota-Koketsu, R., Yang, C. S., Du, A., Sakudo, A., Tsujikawa, M., Yunoki, M. and Ikuta, K. (2011). Development of two types of rapid diagnostic test kits to detect the hemagglutinin or nucleoprotein of the swine-origin pandemic influenza A virus H1N1. Clin Vaccine Immunol 18(3): 494-499.
    
17. Kayamuro, H., Yoshioka, Y., Abe, Y., Arita, S., Katayama, K., Nomura, T., Yoshikawa, T., Kubota-Koketsu, R., Ikuta, K., Okamoto, S., Mori, Y., Kunisawa, J., Kiyono, H., Itoh, N., Nagano, K., Kamada, H., Tsutsumi, Y. and Tsunoda, S. (2010). Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol 84(24): 12703-12712.
    
18. Soonthornsata, B., Tian, Y. S., Utachee, P., Sapsutthipas, S., Isarangkura-na-Ayuthaya, P., Auwanit, W., Takagi, T., Ikuta, K., Sawanpanyalert, P., Kawashita, N. and Kameoka, M. (2010). Design and evaluation of antiretroviral peptides corresponding to the C-terminal heptad repeat region (C-HR) of human immunodeficiency virus type 1 envelope glycoprotein gp41. Virology 405(1): 157-164.
    
19. Kameoka, M., Isarangkura-na-Ayuthaya, P., Kameoka, Y., Sapsutthipas, S., Soonthornsata, B., Nakamura, S., Tokunaga, K., Sawanpanyalert, P., Ikuta, K. and Auwanit, W. (2010). The role of lysine residue at amino acid position 165 of human immunodeficiency virus type 1 CRF01_AE Gag in reducing viral drug susceptibility to protease inhibitors. Virology 405(1): 129-138.
    
20. Arias, J. F., Nishihara, R., Bala, M. and Ikuta, K. (2010). High systemic levels of interleukin-10, interleukin-22 and C-reactive protein in Indian patients are associated with low in vitro replication of HIV-1 subtype C viruses. Retrovirology 7: 15.
    
21. Utachee, P., Nakamura, S., Isarangkura-Na-Ayuthaya, P., Tokunaga, K., Sawanpanyalert, P., Ikuta, K., Auwanit, W. and Kameoka, M. (2010). Two N-linked glycosylation sites in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for the CD4 binding domain. J Virol 84(9): 4311-4320.
    
22. Horie, M., Honda, T., Suzuki, Y., Kobayashi, Y., Daito, T., Oshida, T., Ikuta, K., Jern, P., Gojobori, T., Coffin, J. M. and Tomonaga, K. (2010). Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature 463(7277): 84-87.
    
23. Ueda, M., Daidoji, T., Du, A., Yang, C. S., Ibrahim, M. S., Ikuta, K. and Nakaya, T. (2010). Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells. J Virol 84(6): 3068-3078.
24. Yunoki, M., Kubota-Koketsu, R., Urayama, T., Sasaki, T., Analiwa, D., Konoshima, Y., Ideno, S., Fukunaga, Y., Morikawa, S., Hiroi, S., Takahashi, K., Okuno, Y., Hagiwara, K. and Ikuta, K. (2010). Significant neutralizing activity of human immunoglobulin preparations against pandemic 2009 H1N1. Br J Haematol 148(6): 953-955.
    
25. Honda, T., Horie, M., Daito, T., Ikuta, K. and Tomonaga, K. (2009). Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface. J Virol 83(23): 12622-12625.