Cancer Biology

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    Protocols in Current Issue
    High Fat Diet-induced Breast Cancer Model in Rat
    Authors:  Meng Ju Wu and Chun Ju Chang, date: 07/05/2016, view: 6500, Q&A: 0
    [Abstract] Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Being overweight or obese for a woman at the time she is diagnosed with breast cancer is linked to a high risk of recurrence regardless of treatment factors. In rodents, high body weight is also associated with increased incidence of spontaneous and ...
    Capturing the Driving Role of Tumor-host Crosstalk in a Dynamical Model of Tumor Growth
    Authors:  Sebastien Benzekry, Afshin Beheshti, Philip Hahnfeldt and Lynn Hlatky, date: 11/05/2015, view: 7372, Q&A: 0
    [Abstract] In 1999, Hahnfeldt et al. proposed a mathematical model for tumor growth as dictated by reciprocal communications between tumor and its associated vasculature, introducing the idea that a tumor is supported by a dynamic, rather than a static, carrying capacity. In this original paper, the carrying capacity was equated with the variable ...
    In vivo Lineage-tracing Studies in a Cancer Stem Cell Population in Neuroblastoma
    Authors:  Danielle M. Hsu, Jason M. Shohet and Eugene S. Kim, date: 04/20/2014, view: 8316, Q&A: 0
    [Abstract] Tumors are comprised of heterogeneous subpopulations that may exhibit differing capacity for differentiation, self-renewal, and tumorigenicity. In vivo lineage-tracing studies are a powerful tool for defining the role of tumor subpopulations in tumor growth and as targets for therapeutic agents. This protocol describes using a ...



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