Neuroscience

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    Protocols in Current Issue
    Simple Protocol for Distinguishing Drug-induced Effects on Spatial Memory Acquisition, Consolidation and Retrieval in Mice Using the Morris Water Maze
    Authors:  Ariel K. Frame, Asad Lone, Richard A. Harris and Robert C. Cumming, date: 09/20/2019, view: 212, Q&A: 0
    [Abstract] The Morris water maze (MWM) is one of the most commonly used tests for assessing spatial learning and memory in mice. While the MWM is highly amenable to testing the effects of memory modifying drugs, most studies do not consider the timing or duration of drug exposure when conducting the MWM assay; factors that can strongly influence the effect ...
    Displaced Object Recognition Memory in Rats
    Authors:  Ali N. Mclagan and Jena B. Hales, date: 04/20/2019, view: 1001, Q&A: 0
    [Abstract] The Displaced Object Recognition (DOR) task, sometimes called the Novel Object Location task, assesses spatial recognition memory without navigational demands, explicit instruction, or the need for multiple days of training. This memory task has two phases. First, the subject is familiarized to an open arena with two objects and is allowed to ...
    Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice
    Authors:  Emily A.K. Prieur and Nafisa M. Jadavji, date: 02/05/2019, view: 3493, Q&A: 0
    [Abstract] The global population is aging and the prevalence of age-related diseases, such as Alzheimer's disease and vascular dementia is increasing. Understanding functional impairments and disease processes is of vital importance in order to develop effective therapeutics. Using the natural exploratory behavior of mice, the spontaneous alternation y-maze ...
    Three-chamber Social Approach Task with Optogenetic Stimulation (Mice)
    Authors:  Celeste Leung, Jun Chul Kim and Zhengping Jia, date: 12/20/2018, view: 1601, Q&A: 0
    [Abstract] The formation of social relationships via social interactions and memory are essential for one’s physical and mental health. To date, rodent studies have used the three-chamber social approach test to measure social approach, social novelty, and social memory. In recent years, techniques including optogenetics have been developed to acutely ...
    A Modified Barnes Maze for Juvenile Rats
    Authors:  Nazanin Valibeigi, Daniel G. McHail, Carmen L. Kimball and Theodore C. Dumas, date: 11/20/2018, view: 1704, Q&A: 0
    [Abstract] To better understand neural codes for spatial navigation and to address cognitive development questions, the neurobiology of postnatal hippocampal development is receiving increased attention. While the Morris Water Maze is the gold standard for assessing hippocampal integrity, potential confounds can be difficult to control for in juvenile ...
    Behavioral Evaluation of Odor Memory in Mice
    Authors:  Afif J. Aqrabawi and Jun Chul Kim, date: 09/20/2018, view: 1639, Q&A: 0
    [Abstract] Behavioural tests based on the spontaneous recognition paradigm have been used extensively for examining the memory capacity of rodents. By exploiting their innate preference to investigate novel stimuli, inferences can be drawn about the perceived familiarity of encountered objects. Olfaction is the dominant sense used by mice to navigate their ...
    Assessing Classical Olfactory Fear Conditioning by Behavioral Freezing in Mice
    Authors:  Jordan M. Ross and Max L. Fletcher, date: 09/20/2018, view: 1628, Q&A: 0
    [Abstract] Classical fear conditioning typically involves pairing a discrete cue with a foot shock. Quantifying behavioral freezing to the learned cue is a crucial assay for neuroscience studies focused on learning and memory. Many paradigms utilize discrete stimuli such as tones; however, given mice are odor-driven animals and the wide variety of odorants ...
    Classic Labyrinth Test for Neurobehavioral Evaluation in Wistar Rats
    Author:  Salim Gasmi, date: 09/20/2018, view: 1917, Q&A: 0
    [Abstract] The Classic Labyrinth Test (CLT) is a simple way to evaluate behaviors in rodents such as learning ability, memory, and anxiety. The protocol presented here describes the procedure for use with rats, but the protocol can also be adapted for use in mice if a smaller device is used. In short, the CLT uses a square-shaped maze with a starting point ...
    Trace Fear Conditioning: Procedure for Assessing Complex Hippocampal Function in Mice
    [Abstract] The trace fear conditioning protocol is designed to measure hippocampal function in mice. The protocol includes a neutral conditioned stimulus (tone) and an aversive unconditioned stimulus (shock), separated in time by a trace interval. The trace interval between the tone and the shock critically involves the hippocampus and could be used to ...
    Assessing Experience-dependent Tuning of Song Preference in Fruit Flies (Drosophila melanogaster)
    Authors:  Xiaodong Li, Hiroshi Ishimoto and Azusa Kamikouchi, date: 07/20/2018, view: 2212, Q&A: 0
    [Abstract] In songbirds and higher mammals, early auditory experience during childhood is critical to detect and discriminate sound patterns in adulthood. However, the neural and molecular nature of this acquired ability remains elusive. Here, we describe a new behavioral paradigm with Drosophila melanogaster to investigate how the auditory ...



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