Neuroscience

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    Protocols in Current Issue
    Operant Vapor Self-administration in Mice
    [Abstract]

    Models of drug addiction in rodents are instrumental in understanding the underlying neurobiology. Intravenous self-administration of drugs in mice is currently the most commonly used model; however, several challenges exist due to complications related to catheter patency. To take full advantage of the genetic tools available to study opioid

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    Activity-based Anorexia for Modeling Vulnerability and Resilience in Mice
    Authors:  Jeff A. Beeler and Nesha S. Burghardt, date: 05/05/2021, view: 457, Q&A: 0
    [Abstract]

    Activity-based anorexia (ABA) is a widely used rodent model of anorexia nervosa. It involves combining limited access to food with unlimited access to a running wheel, leading to a paradoxical decrease in food intake, hyperactivity, and life-threatening weight loss. Although initially characterized in rats, ABA has been tested in mice with results

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    Nestlet Shredding and Nest Building Tests to Assess Features of Psychiatric Disorders in Mice
    Authors:  Fabian Dorninger, Gerhard Zeitler and Johannes Berger, date: 12/20/2020, view: 1172, Q&A: 0
    [Abstract]

    Mimicking the various facets of human psychiatric and neurodevelopmental disorders in animal models is a challenging task. Nevertheless, mice have emerged as a widely used model system to study pathophysiology and treatment strategies for these diseases. However, the corresponding behavioral tests are often elaborate and require extensive

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    Maternal Immune Activation with the Viral Mimetic Poly:IC in Pregnant Rats
    Authors:  Thaisa Meira Sandini, Quentin Greba, Brittney Rose Lins and John George Howland, date: 11/20/2020, view: 1160, Q&A: 0
    [Abstract]

    Maternal immune activation (MIA) is increasingly well appreciated as an environmental risk factor for some psychiatric disorders. Administration of proinflammatory compounds such as the synthetic double-stranded RNA molecule polyinosinic-polycytidylic acid (polyI:C) to pregnant rodents results in the release of proinflammatory cytokines in the

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    An Operant Conditioning Model Combined with a Chemogenetic Approach to Study the Neurobiology of Food Addiction in Mice
    Authors:  Elena Martín-García, Laura Domingo-Rodriguez and Rafael Maldonado, date: 10/05/2020, view: 1481, Q&A: 0
    [Abstract] The study of food addiction comprises 3 hallmarks that include the persistence to response without an outcome, the strong motivation for palatable food, and the loss of inhibitory control over food intake that leads to compulsive behavior in addicted individuals. The complex multifactorial nature of this disorder and the unknown neurobiological ...
    Measuring Breathing Patterns in Mice Using Whole-body Plethysmography
    [Abstract] Respiratory dysfunction is among the main cause of severe and fatal pathologies worldwide. The use of effective experimental models and methodologies for the study of the pulmonary pathophysiology is necessary to prevent, control and cure these diseases. Plethysmography, a technique for the assessment of lung function, has been widely applied in ...
    Integration of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons into Rat Brain
    Authors:  Xiling Yin, Ted M. Dawson and Valina L. Dawson, date: 09/05/2020, view: 2797, Q&A: 0
    [Abstract] Human neuron transplantation offers novel opportunities for modeling human neurologic diseases and potentially replacement therapies. However, the complex structure of the human cerebral cortex, which is organized in six layers with tightly interconnected excitatory and inhibitory neuronal networks, presents significant challenges for in vivo ...
    The Discrete Paired-trial Variable-delay T-maze Task to Assess Working Memory in Mice
    Authors:  Gian Marco Leggio, Sebastiano Alfio Torrisi and Francesco Papaleo, date: 07/05/2020, view: 1709, Q&A: 0
    [Abstract] Working memory abnormalities involving the prefrontal cortex (PFC) dramatically contribute to poor functional outcomes in patients with schizophrenia and still represent an unmet therapeutic need. Studies in rodents might provide essential tools to understand the mechanisms underlying PFC-dependent working memory dysfunctions, as well as precious ...
    Enriched Environment Procedures for Rodents: Creating a Standardized Protocol for Diverse Enrichment to Improve Consistency across Research Studies
    Authors:  Bruce C. Harland and John C. Dalrymple-Alford, date: 06/05/2020, view: 1455, Q&A: 0
    [Abstract] Exposure to environmental enrichment has beneficial effects on learning and memory, diverse neurobiological effects, and promotes recovery of function after brain injury. The effect of enrichment is produced by a combination of increased social interaction, physical activity, spatial complexity, and novelty. Procedures in the literature have, ...
    Generation, Analyzing and in-vivo Drug Treatment of Drosophila Models with IBMPFD
    Authors:  Ting Zhang, Bruce A. Hay and Ming Guo, date: 05/20/2020, view: 2001, Q&A: 0
    [Abstract] Missense mutations of p97/cdc48/Valosin-containing protein (VCP) cause inclusion body myopathy, Paget disease with frontotemporal dementia (IBMPFD) and other neurodegenerative diseases. The pathological mechanism of IBMPFD is not clear and there is no treatment. We generated Drosophila models of IBMPFD in adult flight muscle in ...



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