Vector genome loss and epigenetic modifications mediate decline in transgene expression of AAV5 vectors produced in mammalian and insect cells

Young mice administered adult doses of AAV5-hFVIII-SQ achieve therapeutic factor VIII expression into adulthood

Prophylactic prednisolone promotes AAV5 hepatocyte transduction through the novel mechanism of AAV5 coreceptor platelet-derived growth factor receptor alpha upregulation and …

Biochemical and molecular characterization of fungal isolates from California annual grassland soil
The longitudinal kinetics of AAV5 vector integration profiles and evaluation of clonal expansion in mice

The longitudinal kinetics of AAV5 vector integration profiles in mice

Rapid assessment of CRISPR gRNAs with optimized protoplast transformation in Maize

The effect of prophylactic corticosteroid treatment on adeno-associated virus-mediated gene therapy and potential mechanisms of action

Prophylactic corticosteroid treatment in mice improved AAV5 transgene expression through multiple mechanisms

Vector genome loss and epigenetic modifications impact long-term transgene expression of AAV5 vectors produced in mammalian HEK293 and insect Sf cells

Impact of Genome Accessibility and Long-Term Expression of Adeno-Associated Virus 5 Produced in Mammalian (HEK293) and Insect (Sf) Cell Lines

The Effect of Prophylactic Corticosteroid Treatment on Adeno-Associated Virus-Mediated Gene Therapy and Potential Mechanisms of Action

Long-term Expression Comparison of Adeno-Associated Virus (AAV) Vector Produced in HEK293 vs Sf Cell Lines