Education
PhD in Pathobiology, University of Washington, 2023
Lab information
John D. Aitchison
https://www.seattlechildrens.org/research/centers-programs/global-infectious-disease-research/research-areas-and-labs/aitchison-lab/
Research focus
Dengue virus, Beta-coronavirus, host-pathogen interactions, single-domain antibodies, kinase signaling
Publications
1. Bourgeois NM, Wei L, Kaushansky A., Aitchison JD. Exploiting Host Kinases to Combat Dengue Virus Infection and Disease. Antiviral Research. 2025 May 8. https://doi.org/10.1016/j.antiviral.2025.106172.
2. Bourgeois N.M.; Black, J.J.; Bhondeley, M.; Liu, Z. Protein Kinase A Negatively Regulates the Acetic Acid Stress Response in S. cerevisiae. Microorganisms 2024, 12, 1452. https://doi.org/10.3390/microorganisms12071452.
3. Bourgeois NM, Wei L, Ho NNT, Neal ML, Seferos D, Tongogara T, Mast FD, Aitchison JD, Kaushansky A. Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes. Front Cell Infect Microbiol. 2024 Mar 22;14:1264525. doi: 10.3389/fcimb.2024.1264525. PMID: 38585651; PMCID: PMC10995305.
4. Carter, Christoph C.; Mast, Fred D.; Olivier, Jean Paul; Bourgeois, Natasha M.; Kaushansky, Alexis; Aitchison, John D. Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication. Frontiers in Cellular and Infection Microbiology. 2022. Volume 12. DOI: 10.3389/fcimb.2022.979996.
5. Vijayan, Kamalakannan; Wei, Ling; Glennon, Elizabeth; Mattocks, Christa; Bourgeois, Natasha; Staker, Bart; Kaushansky, Alexis. Host targeted interventions as an exciting opportunity to combat malaria. July 1, 2021. Chem. Rev. https://doi.org/10.1021/acs.chemrev.1c00062.
6. Jones, Chloe; Rose SL; Shutt A; Cairo C; Bourgeois, Natasha, Charurat M; Sodora, Don; Wood, Matthew. Maternal HIV status skews transcriptomic response in infant cord blood monocytes exposed to Bacillus Calmette--Guerín. AIDS. 2021 Jan 1;35(1):23-32. doi: 10.1097/QAD.0000000000002706.
7. Tenthorey L., Jeannette; Haloupek, Nicole; López-Blanco, José Ramón; Grob, Patricia; Adamson, Elise; Hartenian, Ella; Nicholas A., Lind; Bourgeois, Natasha M., Chacón, Pablo; Nogales, Eva; Vance, Russell E. 2017 Nov 17. The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion. Science 358 (6365), 888-893. DOI: 10.1126/science.aao1140.