Education
PhD, Banaras Hindu University, 2021
Lab information
David Walker, UCLA
The lab is using the powerful genetics of the fruit fly Drosophila melanogaster to better understand the molecular and cellular mechanisms of aging
Research focus
Aging, Apoptosis, Autophagy, Drosophila, Genetics, Biotechnology, Cell signaling, Developmental genetics, Immunity, Immunogenetics, Inflammaging, Inter-organ communication, Metastasis, Mitophagy, Notch Signaling, Signal transduction, Wingless Signaling.
Publications
https://www.ncbi.nlm.nih.gov/myncbi/vartika.sharma.3/bibliography/public/Sharma V., Sarkar B., Mutsuddi M., Mukherjee A. (2022). Deltex modulates Dpp morphogen gradient formation and affects Dpp signaling in Drosophila. J. Cell Sci. 1;135(17) ):jcs259658. doi: 10.1242/jcs.259658.
Sharma V., Sachan N., Mutsuddi M., Mukherjee A (2022). Somatic clonal analyses using FLP/FRT and MARCM system to understand Notch signaling mechanism and its regulation. Methods Mol Biol. 2022;2472:83-94.
Sharma V., Mutsuddi M., Mukherjee A. (2021). Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila. Genes to cells. 00:1-10. DOI: 10.1111/gtc.12837.
Mishra AK., Sharma V., Mutsuddi M., Mukherjee A. (2021). Signaling cross-talk during development: Context-specific networking of Notch, NF-κB, and JNK pathways during Drosophila development. Cellular Signal. DOI: 10.1016/j.cellsig.2021.109937.
Dutta D., Sharma V., Mutsuddi M., Mukherjee A. (2021). Regulation of Notch signaling by E3 ubiquitin ligases. The FEBS Journal. DOI:10.1111/febs.15792.
Sharma V., Mutsuddi M., Mukherjee A. (2020). Deltex cooperates with TRAF6 to promote apoptosis and cell-migration through Eiger independent JNK activation in Drosophila. Cell Biol Int. 2021; 45:686–700.
Sharma V., Mishra AK., Mutsuddi M., Mukherjee A (2019). Mighty Fly: An introduction to Drosophila. In: Mutsuddi M, Mukherjee A. (eds) Insight into Human Neurodegeneration: Lessons Learnt from Drosophila. Springer. DOI: https://doi.org/10.1007/978-981-13-2218-1_1.
Dutta D., Singh A., Paul MS., Sharma V., Mutsuddi M., Mukherjee A. (2018). Deltex interacts with Eiger and modulates its signaling activity in Drosophila melanogaster. Cellular Signal. 49:17-29.