Education
Doctor, University of Arkansas for Medical Sciences, 2011
Research focus
Dr. Hodeify research portfolio focuses on three themes: (1) the crosstalk between cell cycle, cell death, and calcium signaling during cellular pathology particularly in kidney injury and cancer, (2) regulation of trafficking of membrane proteins, precisely, store-operated calcium channel (Orai1) and sodium potassium pump, (3) applying AI and machine learning models for predicting cellular fate, disease progression, and early diagnosis.
Publications
https://pubmed.ncbi.nlm.nih.gov/?term=hodeify-Hodeify R, Kreydiyyeh S, Zaid LMJ. Identified and potential internalization signals involved in trafficking and regulation of Na+/K+ ATPase activity. Mol Cell Biochem. 2023 Aug 27. doi: 10.1007/s11010-023-04831-y. Epub ahead of print. PMID: 37634170.
-Aboud O, Liu Y, Dahabiyeh L, Abuaisheh A, Li F, Aboubechara JP, Riess J, Bloch O, Hodeify R, Tagkopoulos I, Fiehn O. Profile Characterization of Biogenic Amines in Glioblastoma Patients Undergoing Standard-of-Care Treatment. Biomedicines. 2023 Aug 13;11(8):2261. doi: 10.3390/biomedicines11082261. PMID: 37626757; PMCID: PMC10452138.
-Siddiqui SS, Hodeify R, Mathew S, Alsawaf S, Alghfeli A, Matar R, Merheb M, Marton J, Al Zouabi HA, Sethuvel DPM, Ragupathi NKD, Vazhappilly CG. Differential dose-response effect of cyclosporine A in regulating apoptosis and autophagy markers in MCF-7 cells. Inflammopharmacology. 2023 Aug;31(4):2049-2060. doi: 10.1007/s10787-023-01247-4. Epub 2023 May 19. PMID: 37204695.
Aboud O, Liu YA, Fiehn O, Brydges C, Fragoso R, Lee HS, Riess J, Hodeify R, Bloch O. Application of Machine Learning to Metabolomic Profile Characterization in Glioblastoma Patients Undergoing Concurrent Chemoradiation. Metabolites. 2023 Feb 17;13(2):299. doi: 10.3390/metabo13020299. PMID: 36837918; PMCID: PMC9961856.
-Hodeify R, Ghani A, Matar R, Vazhappilly CG, Merheb M, Zouabi HA, Marton J. Adenosine Triphosphate Protects from Elevated Extracellular Calcium-Induced Damage in Human Proximal Kidney Cells: Using Deep Learning to Predict Cytotoxicity. Cell Physiol Biochem. 2022 Sep 21;56:484-499. doi: 10.33594/000000571. PMID: 36126285.
-Rida R, Hodeify R, Kreydiyyeh S. Adverse effect of FTY720P on colonic Na+ /K+ ATPase is mediated via ERK, p38MAPK, PKC, and PI3K. J Appl Toxicol. 2022 Aug 9. doi: 10.1002/jat.4375. Epub ahead of print. PMID: 35946054.
-Hodeify R, Dib M, Alcantara-Adap E, Courjaret R, Nader N, Reyes CZ, Hammad AS, Hubrack S, Yu F, Machaca K. The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis. Sci Rep. 2021 Jan 27;11(1):2290. doi: 10.1038/s41598-021-82048-z. PMID: 33504898; PMCID: PMC7840751.
-Hodeify R, Dib M, Alcantara-Adap E, Courjaret R, Nader N, Reyes CZ, Hammad AS, Hubrack S, Yu F, Machaca K. The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis. Sci Rep. (2021).
-Hodeify, R., Nandakumar, M., Own, M., Courjaret, R. J., Graumann, J., Hubrack, S. Z., & Machaca, K. The CCT chaperonin is a novel regulator of Ca2+ signaling through modulation of Orai1 trafficking. Science advances, 4(9), eaau1935. doi:10.1126/sciadv.aau1935, (2018).