Dr. Wu earned her medical degree and a doctorate in clinical medicine at the West China Medical College in China. She received her first postdoc training at Smidt heart institute of Cedars Sinai medical center and focused on studying the endovascular inflammation and calcium regulation in HFpEF (Heart Failure with Preserved Ejection Fraction) and testing the efficacy of Cardiosphere-derived cells (CDCs) and their secreted exosomes (CDCexo) for heart failure. She comes to the Alexander Lab with expertise in calcium handling and cardiosphere-derived cell-based therapy in rodents models. Dr. Wu is currently leading our research efforts on studying the mechanisms underlying the development of transthyretin cardiac amyloidosis(ATTR). Her work using iPSC and animal models as well as human samples will undoubtedly lead to important insights into this deadly disease and improve outcomes for cardiac amyloid patients.
https://profiles.stanford.edu/xiaokang-wu
Regenerative Medicine, Translational Medicine, Cell Biology, Molecular Biology, Stem cell, Tissue Engineering, Cardiovascular Diseases, Electrophysiology, AI and machine learning
https://orcid.org/0000-0003-1020-6232-Zhang, K., He, W., Du, Y., Zhou, Y., Wu, X., Zhu, J., ... & Lu, Y. (2022). Inhibitory effect of lanosterol on cataractous lens of cynomolgus monkeys using a subconjunctival drug release system. Precision Clinical Medicine, 5(3).
-de Couto*, G., Mesquita*, T., Wu, X.*, Rajewski, A., Huang, F., Akhmerov, A., ... & Marbán, E. (2022). Cell therapy attenuates endothelial dysfunction in hypertensive rats with heart failure and preserved ejection fraction. AJP-Heart and Circulatory Physiology. (Co-first Author)
-Zhang, R., Wu, X., Xie, C., Gonzalez, D., Norris, R., Li, L., ... & Goldhaber, J. I. (2022). Cardioprotection in ischemia-reperfusion injury achieved by a single amino acid substitution of NCX1 (H165A). Biophysical Journal, 121(3), 91a.
-Z. Zhong, J. Wang, J. Tian, X. Deng, A. Balayan, Y. Sun, Y. Xiang, J. Guan, J. Schimelman, H. Hwang, S. You, X. Wu, C. Ma, X. Shi, E. Yao, S. Deng, S.C. Chen. (2022). “Rapid 3D Bioprinting of a Multicellular Model Recapitulating Pterygium Microenvironment.” Biomaterials, 282, 121391.
-Zhang, R., Wu, X., Xie, C., Gonzalez, D., Lotteau, S., Thomas Gavali, J., Li, L., John, S., Philipson, K.D., Ottolia, M. and Goldhaber, J.I., 2021. A Genetically Modified pH Resistant NCX1 Mouse Prevents Calcium Overload During Acidosis and is Cardioprotective. Circulation, 144.Suppl_1 (2021): A11475-A11475.
-Huang, F., Na, N., Ijichi,T., Wu, X., My Tran, M., Li, L., Marbán, E., de Couto, G. (2021). Exosomally-derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice. Molecular Therapy-Nucleic Acids, 24, 951-960.
-Zhong, Z., Balayan, A., Tian, J., Xiang, Y., Hwang, H. H., Wu, X., ... & Chen, S. (2021). Bioprinting of dual ECM scaffolds encapsulating limbal stem/progenitor cells in active and quiescent statuses. Biofabrication, 3(4), 044101.
-Zhong, Z., Deng, X., Wang, P., Yu, C., Kiratitanaporn, W., Wu, X., ... & Chen, S. (2021). Rapid bioprinting of conjunctival stem cell micro-constructs for subconjunctival ocular injection. Biomaterials, 267, 120462.
-Liang, H., Tsui, B. Y., Ni, H., Valentim, C. C., Baxter, S. L., …Wu, X., & He, L. (2019). Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence. Nature medicine, 25(3), 433-438.
-Kermany, D. S., Goldbaum, M., Cai, W., Valentim, C. C., ... Wu, X., .... & Dong, J. (2018). Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell, 172(5), 1122-1131.
-Liu, Y., Granet, D., Lin, H., Baxter, S., Ouyang, H., Wu, X., ... & Liu, X. (2018). Liu et al. reply. Nature, 556(7699), E3.