My research is at the intersection of studying the blood-brain barrier properties and tailoring therapeutics/drug delivery systems accordingly for more efficient brain targeting. Having a strong background in Pharmaceutics and recent interest in blood-brain barrier modeling, I aspire to enhancing the translation of preclinical data to clinical settings.
https://scholar.google.com.eg/citations?user=Z2pMxGEAAAAJ&hl=en&oi=aoREVIEW ARTICLES AND BOOK CHAPTERS
ElGanainy SO, Cijsouw T, Ali MA, Schoch S, Hanafy AS. (2022). Stereotaxic-assisted gene therapy in Alzheimer’s and Parkinson’s diseases: Therapeutic potentials and clinical frontiers. Expert Review of Neurotherapeutics. 22(4): 319-335.
Hanafy AS, Dietrich D, Fricker G, Lamprecht A. (2021). Blood-brain barrier models: rationale for selection. Advanced Drug Delivery Reviews. (in press)
Hanafy AS, Schoch S, Lamprecht A. (2020). CRISPR/Cas9 delivery potentials in Alzheimer’s Disease management: A mini review. Pharmaceutics. 12(9):801.
Torres-Ortega P, Martínez-Valbuena I, Martí-Andrés G, Hanafy AS.; Luquin M, Garbayo E, Blanco-Prieto M. (2019). Nanobiotechnology in Parkinson’s Disease. In: Nanobiotechnology in Neurodegenerative Diseases, Rai, M.; Yadav, A., Eds. Springer International Publishing; 177-208.
Torres-Ortega PV, Saludas L, Hanafy AS, Garbayo E, Blanco-Prieto MJ. (2019). Micro-and nanotechnology approaches to improve Parkinson's disease therapy. Journal of Controlled Release. 295: 201-213
Wen W, ElSalamouni N, El-Refaie W, Hazzah H, Ali M, Tosi G, Farid R, Blanco-Prieto M, Billa N, Hanafy AS. (2017). Nanotechnology-based Drug Delivery Systems for Alzheimer’s Disease Management: Technical, Industrial, and Clinical Challenges. Journal of Controlled Release. 245: 95-107.
ElHabashy SE, Nazief AM, Adkins CE, Wen MM, ElKamel AH, Hamdan AM, Hanafy AS, Terrell TO, Mohammad AS, Lockman PR, Nounou MI. (2014). Novel Treatment Strategies for Brain Tumors and Metastases. Pharmaceutical Patent Analyst. 3(3): 279–296
PEER REVIEWED PUBLICATIONS
Hanafy AS, Lamprecht, A, Dietrich, D. (2023). Local perfusion of capillaries reveals blood-brain barrier altered beta amyloid homeostasis in Tg2576 murine Alzheimer’s model. (in revision).
Hanafy AS, Steinlein P, Pitsch J, Vana N, Becker A, Schoch S, Lamprecht A, Dietrich D. High-resolution analysis of blood-brain barrier function by micro-impalement of capillaries in brain slices. (in revision in Nature Communications).
Hanafy AS, Steinlein P, Paulußen I, Vana N, Lamprecht, A, Dietrich, D. Two-photon real-time imaging reveals altered blood-brain barrier functions in murine Alzheimer’s disease model. (in preparation).
ElSalamouni N, Hanafy AS. (2021). Hyaluronic-benzydamine oromucosal films outperform conventional mouth rinse in ulcer healing. Journal of Drug Delivery Science and Technology. 65: 102690
Kandil L, Farid R, ElGamal S, Hanafy AS (2021). Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentials in rat brains via antioxidant effect. Drug development and industrial pharmacy. 47(5): 735-740
ElGanainy S, Gowayed M, Agami M, Mohamed P, Belal M, Farid R, Hanafy AS. (2021). Galantamine nanoparticles outperform oral galantamine in an Alzheimer’s rat model: pharmacokinetics and pharmacodynamics. Nanomedicine. 16(15): 1281-1296
Kandil L, Hanafy AS, AbdelHady S. (2020). Galantamine transdermal patch shows higher tolerability over oral galantamine in rheumatoid arthritis rat model. Drug development and industrial pharmacy. 46(6): 996-1004
Hanafy AS, El-Ganainy S. (2020). Thermoresponsive Hyalomer intra-articular hydrogels improve monoiodoacetate-induced osteoarthritis in rats. International Journal of Pharmaceutics. 573: 118859
Hanafy AS, Farid R, Helmy M, ElGamal S. (2016). Pharmacological, Toxicological and Neuronal Localization Assessment of Galantamine/Chitosan Complex Nanoparticles in Rats: Future Potential Contribution in Alzheimer’s Disease Management. Drug Delivery. 23(8): 3111-3122
Hanafy AS, Farid R, ElGamal S. (2015). Complexation as an Approach to Entrap Cationic Drugs into Cationic Nanoparticles Administered Intranasally for Alzheimer's Disease Management: Preparation and Detection in Rat Brain. Drug Development and Industrial Pharmacy. 41(12): 2055-2068
Sokar M, Hanafy AS, ElKamel A, ElGamal S. (2015). Design of Chronomodulated Drug Delivery System of Valsartan: In Vitro Characterization. Indian Journal of Pharmaceutical Sciences. 77(4): 470-477
Sokar M, Hanafy AS, El-Kamel A, ElGamal S. (2013). Pulsatile Core-in-cup Valsartan Tablet Formulations: In Vitro Evaluation. Asian Journal of Pharmaceutical Sciences. 8(4): 234-43