Alok Kumar

Peer-Reviewed Research Articles

1. Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T cell therapy against solid tumors. Konstantinos Lontos, Yiyang Wang, Andrew T Frisch, McLane J Watson, Alok Kumar, Ashley Menk, Yupeng Wang, Benjamin Boyerinas, and Greg M Delgoffe. Journal of Immunotherapy of Cancer, 2022 (in press).

2. Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology. Konstantinos Lontos, Yiyang Wang, Mason Colbert, Alok Kumar, Supriya Joshi, Mary Philbin, Yupeng Wang, Andrew Frisch, Jason Lohmueller, Dayana B. Rivadeneira, Greg M. Delgoffe. Cell Reports, 2022 (In press).

3. Alok Kumar, Kenji Chamoto, Partha S. Chowdhury, Tasuku Honjo. Tumors attenuating T cell mitochondria escape from PD-1 blockade therapy [eLife Sciences; DOI: 10.7554/eLife.52330]; [My first author Ph.D. paper].
Related Press Release and News Updates
a. Blocking energy production in immune cells helps tumours escape treatment. EurekAlert.org (EurekAlert, established in 1996, is a nonprofit news-release distribution platform operated by the American Association for the Advancement of Science (AAAS) as a resource for journalists and the public). https://www.eurekalert.org/pub_releases/2020-03/e-bep030320.php

b. Inhibiting energy production in immune T-cells allows some tumors to escape treatment. News-Medical.net (A UK based news portal established in 2004).
https://www.news-medical.net/news/20200303/Inhibiting-energy-production-in-immune-T-cells-allows-some-tumors-to-escape-treatment.aspx?fbclid=IwAR0ri7gS-QdtRWqLQysuN60IwzU88MP7eezoD1FToUWp2sxShThtD4q_-kg

c. Blocking energy production in immune cells helps tumours escape treatment. Medicalxpress.com (Medical Xpress launched in 2004 and powered by Science X Network) https://medicalxpress.com/news/2020-03-blocking-energy-production-immune-cells.html

d. Mitochondria-boosting compound promotes immunotherapy in mice (Drug target review, is an United Kingdom based science news portal published by Russel Publishing Ltd.) https://www.drugtargetreview.com/news/56851/mitochondria-boosting-compound-promotes-immunotherapy-in-mice/

e. Inhibiting energy production in immune T-cells allows some tumors to escape treatment. (Sound Health and Lasting Wealth). https://www.soundhealthandlastingwealth.com/health-news/inhibiting-energy-production-in-immune-t-cells-allows-some-tumors-to-escape-treatment/

f. Mitochondria-boosting compound promotes immunotherapy in mice – (https://www.medicalschool.tv; https://www.medicalschool.tv/immunology/mitochondria-boosting-compound-promotes-immunotherapy-in-mice-drug-target-review/)

g. Why certain tumors do not respond to immunotherapy. (Biotecnika is a bio-science information portal, based in Bangalore, India. It was established in 2006.) https://www.biotecnika.org/2020/04/how-tumors-hide-from-immunotherapy-scientists-found-an-answer/

Print Issue – Biotecnika Times, 28 April, 2020 https://issuu.com/www.biotecnika.org/docs/biotecika_times_28-04-2020?fr=sMjE2ZTM5ODczNw

4. Partha S. Chowdhury, Alok Kumar, Kenji Chamoto, Tasuku Honjo. Activation of PPAR gamma isoform boosts the efficacy of PD-1 blockade by inducing mitochondrial activity in CD8+ T cell. [Under review in Cancer Science].
5. Madhu Malinee, Alok Kumar, Takuya Hidaka, Masanobu Horie, Kouichi Hasegawa, Masatoshi Hagiwara, Ganesh N Pandian and Hiroshi Sugiyama. Targeted suppression of metastasis regulatory transcription factor SOX2 in various cancer cell lines using a sequence-specific designer pyrrole–imidazole polyamide [Bioorganic & Medicinal Chemistry; doi: 10.1016/j.bmc.2019.115248]
6. Partha S. Chowdhury, Kenji Chamoto, Alok Kumar, Tasuku Honjo. PPAR-induced fatty acid oxidation in T cells ameliorates the antitumor activity of PD-1 blockade by increasing the number of tumor-reactive CD8+ T cells. [Cancer Immunology Research, August 2018, DOI: 10.1158/2326-6066.CIR-18-0095].
7. Tamoghna Ghosh, Santosh K Srivastava, Amit Gaurav, Alok Kumar, Piyush Kumar, Ajit Singh Yadav, Ranjana Pathania, Naveen K Navani. A combination of linalool, vitamin C, and copper synergistically triggers ROS, DNA damage and inhibits Salmonella typhi and multiple antibiotic resistant Vibrio fluvialis. [November 2018, Applied and Environmental Microbiology 85(4) DOI: 10.1128/AEM.02487-18].
8. Kenji Chamoto, Partha Sarathi Chowdhury, Alok Kumar, Kazuhiro Sonomura, Fumihiko Matsuda, Sidonia Fagarasan and Tasuku Honjo “Mitochondria activation chemicals synergize with PD-1 blockade for T cell-dependent anti-tumor activity. [PNAS. 2017 Jan 31;114(5): E761-E770. doi: 10.1073/pnas. 1620433114. Epub 2017 Jan 17].

Reviews
1. Alok Kumar, Greg M. Delgoffe. Nutrient checkpoint’s role in immunity. Nature Immunology Review (2021, in press)
2. Alok Kumar, Kenji Chamoto. Immune metabolism in PD-1 blockade-based cancer immunotherapy. [International Immunology, 2020; DOI: 10.1093/intimm/dxaa046]
3. Alok Kumar, Madhu Malinee. Mitochondrial manipulation improves anti-tumor immunity. [Acta Scientific Cancer Biology 3.12 (2019):28-30.]

Comments
1. Comment on paper “Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells” published in Nature Nanotechnology. Comments published in ‘The New Scientist’ magazine in November, 2021.
Book chapters
1. Poornima Dubey, Deepa Garg, Ishita Matai, Alok Kumar. Trending approaches in electrospinning and electrospraying for biomedical applications [Woodhead Publishing Series in Biomaterials, 2021, Pages 333-354; https://doi.org/10.1016/B978-0-12-822476-2.00008-X].
2. Alok Kumar, Madhu Malinee. Nanoparticles in Immunotherapy Against Cancer. [Standford Publications; in press].
3. Mahak Bansal, Alok Kumar, Madhu Malinee, Tarun Kumar Sharma. Nanomedicine: Current status and future prospects. [January 2020, DOI: 10.1007/978-3-030-29207-2_9; Nanoscience in Medicine Vol. 1, Chapter 9, Springer International Publishing].
4. Alok Kumar*, Madhu Malinee*, Abhijeet Dhiman, Amit Kumar, Tarun Kumar Sharma. Aptamer technology for the detection of food borne pathogens and toxins. Advanced Biosensors for Health Care: Materials and Applications Book [*Shared first author] [June 2019 DOI: 10.1016/B978-0-12-815743-5.00002-0, In book: Advanced Biosensors for Health Care Applications, Chapter: 2, Publisher: Elsevier]
5. Madhu Malinee*, Alok Kumar*, Abhijeet Dhiman, Tarun Kumar Sharma. Aptamer mediated nanobiosensing for health monitoring. Advanced Biosensors for Health Care: Materials and Applications Book [*Shared first author] [June 2019 DOI: 10.1016/B978-0-12-815743-5.00008-1, In book: Advanced Biosensors for Health Care Applications, Chapter: 8, Publisher: Elsevier]

Newsletter
1. ISAJ Newsletter Vol.4 Issue 1: Indicators of mitochondrial activation in killer T cells could be a biomarker to predict the PD-1 blockade therapeutic efficacy. [January 2019 DOI: 10.13140/RG.2.2.10088.11520]
2. Kyoto University, Radioisotope research centre newsletter 2019. ‘T cell mitochondria dysregulation by tumor-derived immunosuppressive factors induces unresponsiveness to the PD-1 blockade cancer immunotherapy’. Alok Kumar, Kenji Chamoto.