Education
Ph.D., Johns Hopkins University, 2016
Lab information
Louis Kunkel Lab in the in Genomics at Children’s Hospital Boston; and Professor of Pediatrics and Genetics, Harvard Medical School.
Dr. Kunkel is a member in the National Academy of Sciences and the American Academy of Arts and Sciences.
Research focus
Muscle biology and disease;
Stem cell and regenerative medicine;
Gene therapy.
Publications
https://scholar.google.com/citations?user=HsqsM28AAAAJ&hl=en1. Lek A, Zhang Y, et al. Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in FSHD. Science Translational Medicine (Accepted).
2. Nance ME, Shi R, Hakim CH, Wasala NB, Yue Y, Pan X, Zhang T, et. al. AAV9 edits muscle stem cells in normal and dystrophic adult mice. Molecular Therapy 2019 27 (9), 1568-1585.
3. Gilbert-Honick J, Ginn B, Zhang Y, et al. Adipose-derived Stem/Stromal Cells on Electrospun Fibrin Microfiber Bundles Enhance Muscle Regeneration in a Volumeric Muscle Loss Model. Cell Transplantation,
2018 Nov; 27(11): 1644–1656.
4. Pakula A, Lek A, Widrick J, Mitsuhashi H, Gwilt K, Gupta V, Rahimov F, Criscione J, Zhang Y, et al. Transgenic zebrafish model of DUX4 misexpression reveals a developmental role in FSHD pathogenesis. Human Molecular Genetics 2019 Jan 15; 28(2): 320–331.
5. Gifford JC, Neto A, Syriani E, Batista AR, Choudhury S, Zhang Y, et al. Identification of Novel AAV Capsids for Skeletal Muscle Gene Transfer by In Vivo Selection in Humanized Mice. Molecular Therapy 2018 26 (5), 165-166.
6. Zhang Y, Chen J, King OD, et al. Morpholino-Mediated Knockdown of DUX4 Towards Facioscapulohumeral Muscular Dystrophy Therapeutics. Molecular Therapy 2016 Aug;24(8):1405-11.
7. Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y et al. Concordant but varied phenotypes among patient-specific myoblasts of Duchenne muscular dystrophy revealed by human iPSC-based model. Cell Reports 2016 Jun 7; 15(10):2301-12.
8. Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y et al. In vivo selection yields novel AAV-B1 capsid for CNS and muscle gene therapy. Molecular Therapy 2016 Aug; 24(7):1247-57.
9. Zhang Y, King OD, Rahimov F, et al. Human skeletal muscle xenograft as a new preclinical model for muscle disorders. Human Molecular Genetics 2014 Jun 15; 23(12):3180-8.
10. Lu Q, Zhang Y, and Elisseeff JH. Carnitine and acetylcarnitine modulate mesenchymal differentiation of adult stem cells. J Tissue Eng Regen Med. 2013 Apr 29.
11. Wang L, Liu Q, Hu Z, Zhang Y, Wu C, Yang M, Wang P. A novel electrochemical biosensor based on dynamic polymerase-extending hybridization for E. coli O157:H7 DNA detection. Talanta, 78(3), 15 May 2009.
12. Wang L, Wu C, Hu Z, Zhang Y et al. Sensing Escherichia coli O157:H7 via frequency shift through a self-assembled monolayer based QCM immunosensor. Journal of Zhejiang University Science B 9 (2), 121-131.