Education
Ph.D, Yokohama City University Graduate School of Medicine, Japan, 1995
Current position
Professor, Department of Immunology, Yokohama City University Graduate School of Medicine, Japan
Publications
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Kurotaki, D., Sasaki, H. and Tamura, T. (2017). Transcriptional control of monocyte and macrophage development. Int Immunol 29(3): 97-107.
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Ban, T., Sato, G. R., Nishiyama, A., Akiyama, A., Takasuna, M., Umehara, M., Suzuki, S., Ichino, M., Matsunaga, S., Kimura, A., Kimura, Y., Yanai, H., Miyashita, S., Kuromitsu, J., Tsukahara, K., Yoshimatsu, K., Endo, I., Yamamoto, T., Hirano, H., Ryo, A., Taniguchi, T. and Tamura, T. (2016). Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45(2): 319-332.
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Kurotaki, D. and Tamura, T. (2016). Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8. J Interferon Cytokine Res 36(7): 433-441.
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Sasaki, H., Kurotaki, D. and Tamura, T. (2016). Regulation of basophil and mast cell development by transcription factors. Allergol Int 65(2): 127-134.
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Sasaki, H., Kurotaki, D., Osato, N., Sato, H., Sasaki, I., Koizumi, S., Wang, H., Kaneda, C., Nishiyama, A., Kaisho, T., Aburatani, H., Morse, H. C., 3rd, Ozato, K. and Tamura, T. (2015). Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. Blood 125(2): 358-369.
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Kurotaki, D., Uede, T. and Tamura, T. (2015). Functions and development of red pulp macrophages. Microbiol Immunol 59(2): 55-62.
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Tamura, T., Kurotaki, D. and Koizumi, S. (2015). Regulation of myelopoiesis by the transcription factor IRF8. Int J Hematol 101(4): 342-351.
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Kurotaki, D., Yamamoto, M., Nishiyama, A., Uno, K., Ban, T., Ichino, M., Sasaki, H., Matsunaga, S., Yoshinari, M., Ryo, A., Nakazawa, M., Ozato, K. and Tamura, T. (2014). IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils. Nat Commun 5: 4978.
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Watanabe, T., Hotta, C., Koizumi, S., Miyashita, K., Nakabayashi, J., Kurotaki, D., Sato, G. R., Yamamoto, M., Nakazawa, M., Fujita, H., Sakai, R., Fujisawa, S., Nishiyama, A., Ikezawa, Z., Aihara, M., Ishigatsubo, Y. and Tamura, T. (2013). The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myelogenous leukemia. Cancer Res 73(22): 6642-6653.
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Kurotaki, D., Osato, N., Nishiyama, A., Yamamoto, M., Ban, T., Sato, H., Nakabayashi, J., Umehara, M., Miyake, N., Matsumoto, N., Nakazawa, M., Ozato, K. and Tamura, T. (2013). Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood 121(10): 1839-1849.
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Yamamoto, M., Kato, T., Hotta, C., Nishiyama, A., Kurotaki, D., Yoshinari, M., Takami, M., Ichino, M., Nakazawa, M., Matsuyama, T., Kamijo, R., Kitagawa, S., Ozato, K. and Tamura, T. (2011). Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development. PLoS One 6(10): e25812.
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Savitsky, D. A., Yanai, H., Tamura, T., Taniguchi, T. and Honda, K. (2010). Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. Proc Natl Acad Sci U S A 107(22): 10154-10159.
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Nakajima, A., Nishimura, K., Nakaima, Y., Oh, T., Noguchi, S., Taniguchi, T. and Tamura, T. (2009). Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene. Proc Natl Acad Sci U S A 106(30): 12448-12452.
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Tamura, T., Smith, M., Kanno, T., Dasenbrock, H., Nishiyama, A. and Ozato, K. (2009). Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. J Biol Chem 284(18): 12217-12225.
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Couzinet, A., Tamura, K., Chen, H. M., Nishimura, K., Wang, Z., Morishita, Y., Takeda, K., Yagita, H., Yanai, H., Taniguchi, T. and Tamura, T. (2008). A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis. Proc Natl Acad Sci U S A 105(7): 2556-2561.
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Tamura, T., Yanai, H., Savitsky, D. and Taniguchi, T. (2008). The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26: 535-584.
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Tamura, T., Thotakura, P., Tanaka, T. S., Ko, M. S. and Ozato, K. (2005). Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood 106(6): 1938-1947.
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Tamura, T., Tailor, P., Yamaoka, K., Kong, H. J., Tsujimura, H., O'Shea, J. J., Singh, H. and Ozato, K. (2005). IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol 174(5): 2573-2581.
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Tamura, T., Kong, H. J., Tunyaplin, C., Tsujimura, H., Calame, K. and Ozato, K. (2003). ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells. Blood 102: 4547-4554.
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Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T. and Ozato, K. (2000). ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 13(2): 155-165.
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Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S. and Taniguchi, T. (1995). An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376(6541): 596-599.