Daan C. Swarts
  • Post-Doc, Department of Biochemistry, University of Zurich, Switzerland
Research fields
  • Biochemistry
Personal information


PhD, Wageningen UR, 2015

Lab information

Martin Jinek lab

Research focus

-Structural biology
-Protein-nucleic acid interactions


First author publications
8. JW Hegge*, DC Swarts*, J van der Oost (2017). Prokaryotic Argonaute proteins - novel genome-editing tools? Nature Reviews Microbiology nrmicro.2017.73
7. DC Swarts, J van der Oost, M Jinek (2017). Structural basis for guide RNA processing and seed-dependent DNA targeting by Cas12a. Molecular Cell 66, 221-233
6. DC Swarts*, M Szczepaniak*, G Sheng*, SD Chandradoss, Y Zhu, EM Timmers, Y Zhang, H Zhao, J Lou, Y Wang, C Joo, J van der Oost (2017) Autonomous generation and loading of DNA guides by bacterial Argonaute. Molecular Cell 65, 985-998
5. DC Swarts, JW Hegge, I Hinojo, M Shiimori, M Ellis, J Dumrongkulraksa, RM Terns, MP Terns, J van der Oost (2015) Argonaute of archaeon Pyrococcus furiosus is a DNA-guided nuclease that targets cognate DNA. Nucleic Acids Research, 43: 5120-5129
4. DC Swarts, JJ Koehorst, ER Westra, PJ Schaap, J van der Oost (2015) Effects of Argonaute on gene expression in Thermus thermophilus. PLoS ONE, 10(4): e0124880
3. DC Swarts, K Makarova, Y Wang, K Nakanishi, RF Ketting, EV Koonin, DJ Patel, J van der Oost (2014) The evolutionary journey of Argonaute proteins. Nat. Struc. Mol. Biol. Vol. 21, 743-753
2. DC Swarts*, MJ Jore*, ER Westra, Y Zhu, JH Janssen, AP Snijders, Y Wang, DJ Patel, J Berenguer, SJJ Brouns, J van der Oost (2014) DNA-guided DNA interference by a prokaryotic Argonaute. Nature, Vol. 507, Issue 7491, 258-261
1. DC Swarts, C Mosterd, MWJ van Passel, SJJ Brouns (2012) CRISPR Interference Directs Strand Specific Spacer Acquisition. PLoS ONE, 7(4): e35888

Co-author publications
6. J van der Oost, DC Swarts, MM Jore (2014) Prokaryotic Argonautes – variations on the RNA interference theme. Microbial Cell, Vol. 1, Issue 5, 158-159
5. T Künne, DC Swarts, SJJ Brouns (2014) Planting the seed: Target recognition of short guide RNAs. Trends in Microbiology, Vol. 22, Issue 2, 74-83
4. G Sheng*, H Zhao*, J Wang, Y Rao, W Tian, DC Swarts, J van der Oost, DJ Patel, Y Wang (2014) Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc. Natl. Acad. Sci. USA, Vol. 111, Issue 2, 652-657
3. ER Westra, DC Swarts, RHJ Staals, MM Jore, SJJ Brouns, J van der Oost (2012) The CRISPRs, They Are A-Changin’: How Prokaryotes Generate Adaptive Immunity. Annual Reviews Genetics, Vol. 46
2. CM Plugge, AM Henstra, P Worm, DC Swarts, AH Paultisch-Fuchs, JCM Scholten, A Lykidis, AL Lapidus, E Goltsman, E Kim, E McDonald, L Rohlin, BR Crable, RP Gunsalus, AJM Stams, MJ McInerney (2012) Complete genome sequence of Syntrophobacter fumaroxidans strain (MPOBT). Standards in Genomic Sciences, Vol. 7 91-106
1. F Blombach, H Launay, V Zorraquino, DC Swarts, LD Cabrita, D Benelli, J Christodoulou, P Londei, J van der Oost (2011) An HflX-Type GTPase from Sulfolobus solfataricus binds to the 50S Ribosomal Subunit in All Nucleotide-Bound States. Journal of Bacteriology, Vol. 193 2861-2867

Peer-reviewed protocol publications
2. DC Swarts, ER Westra, SJJ Brouns, J van der Oost (2014) Purification and Sequencing of DNA guides from Prokaryotic Argonaute. Bio-protocol, Vol 4, Issue 22
1. DC Swarts, MM Jore, John van der Oost (2014) Expression and Purification of the Thermus thermophilus Argonaute Protein. Bio-protocol, Vol 4, Issue 19

*These authors contributed equally
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