Education
Master of Science: Fudan University, Shanghai, 2000
Ph.D. in University of Tuebingen, Germany, 2006
Current position
Acting Instructor, Department of Pharmacology, University of Washington, USA
Publications
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Xiang, Y. Y., Chen, X., Li, J., Wang, S., Faclier, G., Macdonald, J. F., Hogg, J. C., Orser, B. A. and Lu, W. Y. (2013). Isoflurane Regulates Atypical Type-A gamma-Aminobutyric Acid Receptors in Alveolar Type II Epithelial Cells. Anesthesiology 118(5): 1065-1075.
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Chen, X., Xia, Z. and Storm, D. R. (2012). Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase. J Neurosci 32(45): 15769-15778.
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Chen, X., Whissell, P., Orser, B. A. and MacDonald, J. F. (2011). Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. PLoS One 6(7): e21970.
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Chen, X., Li, M., Xiong, Z. G., Orser, B. A., Macdonald, J. F. and Lu, W. Y. (2011). An anti-coagulation agent Futhan preferentially targets GABA(A) receptors in lungepithelia: implication in treating asthma. Int J Physiol Pathophysiol Pharmacol 3(4): 249-256.
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Chen, X., Qiu, L., Li, M., Durrnagel, S., Orser, B. A., Xiong, Z. G. and MacDonald, J. F. (2010). Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology 58(7): 1045-1053.
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Chen, X., Numata, T., Li, M., Mori, Y., Orser, B. A., Jackson, M. F., Xiong, Z. G. and MacDonald, J. F. (2010). The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations. Mol Brain 3: 38.
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Chen, X., Orser, B. A. and MacDonald, J. F. (2010). Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders. Eur J Pharmacol 648(1-3): 15-23.
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Paukert, M., Chen, X., Polleichtner, G., Schindelin, H. and Grunder, S. (2008). Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a. J Biol Chem 283(1): 572-581.
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Chen, X., Polleichtner, G., Kadurin, I. and Grunder, S. (2007). Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+. J Biol Chem 282(42): 30406-30413.
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Chen, X. and Grunder, S. (2007). Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a. J Physiol 579(Pt 3): 657-670.
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Chen, X., Paukert, M., Kadurin, I., Pusch, M. and Grunder, S. (2006). Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium. Neuropharmacology 50(8): 964-974.
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Chen, X., Kalbacher, H. and Grunder, S. (2006). Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependent. J Gen Physiol 127(3): 267-276.
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Chen, X., Kalbacher, H. and Grunder, S. (2005). The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity. J Gen Physiol 126(1): 71-79.