Miao He
  • Principal Investigator, Institutes of Brain Science Fudan University
Research fields
  • Neuroscience
Personal information


PhD, State University of New York at Stony Brook, 2011

Lab information

Miao He Lab

Research focus

Neuronal diversity
Genetic targeting
Neural circuit


1. Qi Y#, Zhao R, Tian J, Lu J, He M*, Tai Y*. Specific and Plastic: Chandelier Cell-to-Axon Initial Segment Connections in Shaping Functional Cortical Network. Neurosci Bull. 2024 (Accepted)
2. Yu Q#, Liu L# , Du M# , Müller D , Gu Y , Gao Z , Xin X, Gu Y , He M , Marquardt T *, Wang L*. Sacral Neural Crest-Independent Origin of the Enteric Nervous System in Mouse. Gastroenterology. 2024 Mar 5:S0016-5085(24)00241-5. Online ahead of print.
3. Cao Z, Min X, Xie X, Huang M, Liu Y, Sun W, Xu G, He M, He K*, Li Y, Yuan J*. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2320383121. doi: 10.1073/pnas.2320383121. Epub 2024 Jan 30.
4. Zhang Q#, Liu X#, Wu J Gong L*, He M*. Combinatorial genetic strategies for dissecting cell lineages, cell types, and gene function in the mouse brain. Dev Growth Differ. 2023 Dec;65(9):546-553.
5. Liu Y, Zhao Y, Wu J, Liu T, Tang M, Yao Y, Xue P, He M, Xu Y, Zhang P, Gu M, Qu W, Zhang Y*. Lithium impacts the function of hematopoietic stem cells via disturbing the endoplasmic reticulum stress and Hsp90 signaling. Food Chem Toxicol. 2023 Nov:181:114081.
6. Wang R#, Xiao L#, Pan J#, Bao G#, Zhu Y, Zhu D, Wang J, Pei C, Ma Q, Fu X, Wang Z, Zhu M, Wang G, Gong L, Tong Q, Jiang M, Hu J, He M, Wang Y, Li T, Liang C, Li W, Xia C, Li Z, Ma DK, Tan M, Liu JY, Jiang W*, Luo C*, Yu B*, Dang Y*. Natural product P57 induces hypothermia through targeting pyridoxal kinase. Nat Commun. 2023 Sep 26;14(1):5984.
7. Tang M, Zhao Y, Zhai Y, Zhang Y, Liu Y, Liu T, Wu J, He L, Yao Y, Xue P, He M, Xu Y, Feng S, Qu W, Zhang Y*. Mercury chloride activates the IFNγ-IRF1 signaling in myeloid progenitors and promotes monopoiesis in mice. Environ Pollut. 2023 Nov 15:337:122583.
8. Zhao Y, Wu J, Xu H, Li Q, Zhang Y, Zhai Y, Tang M, Liu Y, Liu T, Ye Y, He M, He R, Xu Y, Zhou Z, Kan H, Zhang Y*. Lead exposure suppresses the Wnt3a/β-catenin signaling to increase the quiescence of hematopoietic stem cells via reducing the expression of CD70 on bone marrow-resident macrophages. Toxicol Sci. 2023 Jul 12;195(1):123-142.
9. Huilgol D, Levine JM, Galbavy W, Wang BS, He M, Suryanarayana SM, Huang ZJ*. Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex. Neuron. 2023 Aug 16;111(16):2557-2569.e4.
10. Guo H, Jiang JB, Xu W, Zhang MT, Chen H, Shi HY, Wang L, He M, Lazarus M, Li SQ, Huang ZL, Qu WM. Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice. Nat Commun. 2023 Apr 24;14(1):2346.
11. Wang Y L, Wang L, Xu W, He M, Dong H, Shi HY, Chen Y Q, and Huang Z L*, Paraventricular thalamus controls consciousness transitions during propofol anaesthesia in mice. Br J Anaesth, 2023 Jun. 130(6):698-708
12. Zhang Y, Zhao Y, Zhai Y, He J, Tang M, Liu Y, Yao Y, Xue P, He M, Li Q, Xu Y, Qu W, and Zhang Y, Cadmium impairs the development of natural killer cells and bidirectionally modifies their capacity for cytotoxicity. Chemosphere, 2023. 311(Pt 1): p. 137068.
13. Wu J, Zhao Z, Shi Y, He M*. Cortical VIP+ Interneurons in the Upper and Deeper Layers Are Transcriptionally Distinct. J Mol Neurosci. 2022 Aug;72(8):1779-1795.
14. Zhou K, Xu H, Lu S, Jiang S, Hou G, Deng X, He M, and Zhu Y, Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice. Nat Commun, 2022. 13(1): p. 6244.
15. Wang D, Wu J, Liu P, Li X, Li J, He M, Li A*. VIP interneurons regulate olfactory bulb output and contribute to odor detection and discrimination. Cell Rep. 2022 Feb 15;38(7):110383. doi: 10.1016/j.celrep.2022.110383.
16. Zhai Y, Zhao Y, Zhang Y, He J, Tang M, Liu Y, Yang G, Xue P, Yao Y, He M, Xu Y, Qu W, Zhang Y*.Lead suppresses interferon γ to induce splenomegaly via modification on splenic endothelial cells and lymphoid tissue organizer cells in mice. Ecotoxicol Environ Saf. 2022 Aug 31;244:114046. doi: 10.1016/j.ecoenv.2022.114046. Online ahead of print
17. Wu J#, Liu P#, Mao X#, Qiu F, Gong L, Wu J, Wang D, He M*, and Li A*. Ablation of microRNAs in VIP+ interneurons impairs olfactory discrimination and decreases neural activity in the olfactory bulb. Acta Physiol (Oxf), 2022. 234(2): p. e13767.
18. Gong L#, Liu X#, Wu J, He M*. Emerging strategies for the genetic dissection of gene functions, cell types, and neural circuits in the mammalian brain. Mol Psychiatry. 2022 Jan;27(1):422-435. (Invited Review)
19. Zhao Y, Zhang Y, He J, Zhai Y, Yang G, Xue P, Yao Y, He M, Qu W, and Zhang Y*. Cadmium Suppresses Bone Marrow Thrombopoietin Production and Impairs Megakaryocytopoiesis in Mice. Toxicol Sci, 2022. 186(2): 309-322.
20. Zhang C, Zhu H, Ni Z, Xin Q, Zhou T, Wu R, Gao G, Gao Z, Ma H, Li H, He M, Zhang J, Cheng H, Hu H*. Dynamics of a disinhibitory prefrontal microcircuit in controlling social competition. Neuron. 2022 Feb; 110(3):516-531.e6.
21. He J, Zhao Y, Zhu T, Xue P, Zheng W, Yao Y, Qu W, Jia X, Lu R, He M, Zhang Y*. Mercury Chloride Impacts on the Development of Erythrocytes and Megakaryocytes in Mice. Toxics. 2021 Oct 7;9(10):252.
22. Zhang X, Guan W, Yang T, Furlan A, Xiao X, Yu K, An X, Galbavy W, Ramakrishnan C, Deisseroth K, Ritola K, Hantman A, He M, Josh Huang Z, Li B*. Genetically identified amygdala-striatal circuits for valence-specific behaviors. Nat Neurosci. 2021 Nov; 24(11):1586-1600..
23. Matho KS, Huilgol D#, Galbavy W#, He M#, Kim G#, An X, Lu J, Wu P, Di Bella DJ, Shetty AS, Palaniswamy R, Hatfield J, Raudales R, Narasimhan A, Gamache E, Levine JM, Tucciarone J, Szelenyi E, Harris JA, Mitra PP, Osten P, Arlotta P, Huang ZJ* Genetic dissection of the glutamatergic neuron system in cerebral cortex. Nature. 2021 Oct;598(7879):182-187.
24. Huang M, Li D, Cheng X, Pei Q, Xie Z, Gu H, Zhang X, Chen Z, Liu A, Wang Y, Sun F, Li Y, Zhang J, He M, Xie Y, Zhang F, Qi X, Shang C, Cao P*. The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice. Nat Commun. 2021 Jul 20;12(1):4409.
25. Zhang YH, Xu M, Li S, Wu H, Shi X, Guo X. Mu W, Gong L, Yao M, He M. Wu QF*. Cascade Diversification Directs the Generation of Neuronal Diversity in the Hypothalamus. Cell Stem Cell. 2021 Aug 5;28(8):1483-1499.e8.
26. Wu X, Zhang Q, Gong L, He M*. Sequencing-Based High-Throughput Neuroanatomy: From Mapseq to Bricseq and Beyond. Neurosci Bull. 2021 May;37(5):746-750
27. Li X, Liu G, Yang L, Li Z, Zhang Z, Xu Z, Cai Y, Du H, Su Z, Wang Z, Duan Y, Chen H, Shang Z, You Y, Zhang Q, He M, Chen B, Yang Z*. Decoding Cortical Glial Cell Development. Neurosci Bull. 2021 Apr;37(4):440-460.
28. Hou Y#, Zhang Q#, Liu H#, Wu J, Shi Y, Qi Y, Shao M, Yang Z, Lu J, Wu Z, Gong L*, He M*. Topographical organization of mammillary neurogenesis and efferent projections in the mouse brain. Cell Rep. 2021 Feb 9;34(6):108712
29. Zhao Y, Li Q, Zhu T, He J, Xue P, Zheng W, Yao Y, Qu W, Zhou Z, Lu R, Zhou Z, He R, He M, Zhang Y.Lead in Synergism with IFNγ Acts on Bone Marrow-Resident Macrophages to Increase the Quiescence of Hematopoietic Stem Cells. Toxicol Sci. 2021 Jan 23:kfab001
30. Wang B, Sarria M, An X, He M, Alam NM, Prusky GT, Crair M, HuangZJ. Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex. Neuron 2021 Feb 3;109(3):502-515.e7.
31. Xiao X, Deng H, Furlan A, Yang T, Zhang X, Hwang GR, Tucciarone J, Wu P, He M, Palaniswamy R, Ramakrishnan C, Ritola K, Hantman A, Deisseroth K, Osten P, Huang ZJ, Li B*. A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. Cell. 2020 Oct 1;183(1):211-227.e20.
32. Yang WZ, Du X, Zhang W, Gao C, Xie H, Xiao Y, Jia X, Liu J, Xu J, Fu X, Tu H, Fu X, Ni X, He M, Yang J, Wang H, Yang H, Xu XH, Shen WL. Parabrachial neuron types categorically encode thermoregulation variables during heat defense. Sci Adv. 2020 Sep 2;6(36):eabb9414.
33. Liu L, Xu H, Wang J, Li J, Tian Y, Zheng J, He M, Xu TL, Wu ZY, Li XM, Duan SM, Xu H. Cell type-differential modulation of prefrontal cortical GABAergic interneurons on low gamma rhythm and social interaction. Sci Adv. 2020 Jul 22;6(30):eaay4073.
34. Liu X, Ma L, Liu H, Gan J, Xu Y, Zhang T, Mu P, Wu J, Shi Y, Zhang Y, Gong L, He M*. Cell-type-specific gene inactivation and in situ restoration via recombinase-based flipping of targeted genomic region. J Neurosci. 2020 Sep 9;40(37):7169-7186. (Research Spotlight)
35. Zhu T, Zhao Y, Zhang P, Shao Y, He J, Xue P, Zheng W, Qu W, Jia X, Zhou Z, Lu R, He M, Zhang Y*. Lead impairs the development of innate lymphoid cells by impeding the differentiation of their progenitors. Toxicol Sci. 2020 May 19:kfaa074.
36. Zhang Y, Liu G, Guo T, Liang XG, Du H, Yang L, Bhaduri A, Li X, Xu Z, Zhang Z, Li Z, He M, Tsyporin J, Kriegstein AR, Rubenstein JL, Yang Z*, Chen B*. Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog. Cell Rep. 2020 Mar 31;30(13):4490-4504.e4.
37. Cong W, Shi Y, Qi Y, Wu J, Gong L, He M*. Viral approaches to study the mammalian brain: Lineage tracing, circuit dissection and therapeutic applications. J Neurosci Methods. 2020 Apr 1;335:108629. (Invited Review)
38. Qiu F, Mao X, Liu P, Wu J, Zhang Y, Sun D, Zhu Y, Gong L, Shao M, Fan K, Chen J, Lu J, Jiang Y, Zhang Y, Curia G, Li A, He M*. microRNA deficiency in VIP+ interneurons leads to cortical circuit dysfunction. Cerebral Cortex 2020 Apr;30(1): 2229–2249
39. Xu H, Liu L, Tian Y, Wang J, Li J, Zheng J, Zhao H, He M, Xu TL, Duan S, Xu H.A* Disinhibitory microcircuit mediates conditioned social fear in the prefrontal cortex. Neuron. 2019 May 8;102(3):668-682.e5.
40. Chen Z, Yuan X, Dong H, Wu Y, Chen G, He M, Qu W, Huang Z*.(2019) Whole-brain neural connectivity to lateral pontine tegmentum GABAergic neurons in mice. Frontiers in Neuroscience, 2019 Apr 24;13:375.
41. Yang, Z, Zhao, Y, Li, Q, Shao, Y, Yu, X, Cong, W, Jia, X, Qu, W, Cheng, L, Xue, P, Zhou, Z, He, M, and Zhang, Y, Developmental exposure to mercury chloride impairs social behavior in male offspring dependent on genetic background and maternal autoimmune environment. Toxicology and Applied Pharmacology, 2019. 370: p. 1-13.
42. Li, J, Wang C, Zhang Z, Wen Y, An L, Liang Q, Xu Z, Wei S, Li W, Guo T, Liu G, Tao G, You Y, Du H, Fu Z, He M, Chen B, Campbell K, Alvarez-Buylla A, Rubenstein J. L, Yang Z*. Transcription factors sp8 and sp9 coordinately regulate olfactory bulb interneuron development. Cereb Cortex 2018 Sep 1;28(9):3278-3294.
43. Kelly SM, Raudales R, He M, Lee JH, Kim Y, Gibb LG, Wu P, Matho K, Osten P, Graybiel AM, Huang ZJ*. Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization. Neuron. 2018 Jul 25;99(2):345-361.e4.
44. Luo SX, Huang J, Li Q, Mohammad H, Lee CY, Krishna K, Kok AM, Tan YL, Lim JY, Li H, Yeow LY, Sun J, He M, Grandjean J, Sajikumar S, Han W, Fu Y*. Regulation of feeding by somatostatin neurons in the tuberal nucleus. Science. 2018 Jul 6;361(6397):76-81.
45. Zhao Y, Li Q, Yang Z, Shao Y, Xue P, Qu W, Jia X, Cheng L, He M, He R, Zhou Z, Zhang Y*. Cadmium activates non-canonical Wnt signaling to impair hematopoietic stem cell function in mice. Toxicol Sci. 2018 Jun 25.
46. Li Q, Yang Z, Zhang P, Zhao Y, Yu X, Xue P, Shao Y, Li Q, Jia X, Zhang Q, Cheng L, He M, Zhou Z, Zhang Y*. Mercury impact on hematopoietic stem cells is regulated by IFNγ-dependent bone marrow-resident macrophages in mice. Toxicol Lett. 2018 May 31;295:54-63.
47. He M*, Huang ZJ*. Genetic approaches to access cell types in mammalian nervous systems. Curr Opin Neurobiol. 2018 Jun;50:109-118.
48. Schiff HC, Bouhuis A, Yu K, Penzo MA, Li H, He M, Li B*. An Insula-Central Amygdala Circuit for Guiding Tastant-Reinforced Choice Behavior, J Neurosci, 2018.2.7, 38(6): 1418~1429
49. Paul A, Crow M, Raudales R, He M, Gillis J, Huang ZJ*. Transcriptional architecture of synaptic communication delineates GABAergic neuron identity. Cell 2017; 171(3): 522-539 e520.
50. Kim, Y, Yang G. R, Pradhan K, Venkataraju K. U, Bota M, Garcia Del Molino LC, Fitzgerald G, Ram K, He M, Levine J. M, Mitra P, Huang ZJ, Wang X. J, Osten P. Brain-wide maps reveal stereotyped cell-type-based cortical architecture and subcortical sexual dimorphism. Cell 2017; 171(2): 456-469 e422.
51. Yu, K, Ahrens S, Zhang X, Schiff H, Ramakrishnan C, Fenno L, Deisseroth K, Zhao F, Luo MH, Gong L, He M, Zhou P, Paninski L, Li B. The central amygdala controls learning in the lateral amygdala. Nat Neurosci 2017; 20(12): 1680-1685.
52. Lu J, Tucciarone J, Padilla-Coreano N, He M, Gordon JA, Huang ZJ. Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells. Nat Neurosci 2017; 20(10): 1377-1383.
53. Li Q, Zhang P, Yu X, Zhao Y, Li Q, Zhang Y, Yang Z, Xie Y, Xue P, Sun S, Jia X, Zhou Z, He M, Zhang Y. Lead transiently promotes granulocyte-macrophage progenitor differentiation and subsequently suppresses common myeloid progenitor differentiation. Toxicol Sci 2017.
54. He M, Tucciarone J, Lee S, Nigro M. J, Kim Y, Levine J. M, Kelly S. M, Krugikov I, Wu P, Chen Y, Gong L, Hou Y, Osten P, Rudy B, Huang ZJ. Strategies and tools for combinatorial targeting of GABAergic neurons in mouse cerebral cortex. Neuron 2016; 91(6): 1228-1243.
55. ZhangQ, Zhang Y, Wang C, Xu Z, Liang Q, An L, Li J, Liu Z, You Y, He M, Mao Y, Chen B, Xiong Z. Q, Rubenstein J. L, Yang Z. The zinc finger transcription factor sp9 is required for the development of striatopallidal projection neurons. Cell Rep 2016; 16(5): 1431-1444.
56. Penzo MA, Robert V, Tucciarone J, De Bundel D, Wang M, Van Aelst L, Darvas M, Parada LF, Palmiter RD, He M, Huang ZJ, Li B. The paraventricular thalamus controls a central amygdala fear circuit. Nature 2015; 519, 455-459.
57. Zhou, X, Liu F, Tian M, Xu Z, Liang Q, Wang C, Li J, Liu Z, Tang K, He M, Yang Z. Transcription factors coup-tfi and coup-TFII are required for the production of granule cells in the mouse olfactory bulb. Development 2015; 142(9): 1593-1605.
58. Ahrens S, Jaramillo S, Yu K, Ghosh S, Hwang GR, Paik R, Lai C, He M, Huang ZJ, and Li B. ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection. Nat Neurosci 2015; 18, 104-111.
59. Fenno LE, Mattis J, Ramakrishnan C, Hyun M, Lee S. Y, He M, Tucciarone J, Selimbeyoglu A, Berndt A, Grosenick L, Zalocusky KA, Bernstein H, Swanson H, Perry C, Diester I, Boyce FM, Bass CE, Neve R, Huang ZJ, Deisseroth K. Targeting cells with single vectors using multiple-feature boolean logic. Nat Methods 2014; 11(7): 763-772.
60. Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M. Inhibition of inhibition in visual cortex: The logic of connections between molecularly distinct interneurons. Nat Neurosci 2013; 16(8): 1068-1076.
61. He M, Liu Y, Wang X, Zhang MQ, Hannon GJ, Huang ZJ. Cell-type-based analysis of microRNA profiles in the mouse brain. Neuron 2012; 73(1): 35-48.
62. Taniguchi H, He M, Wu P, Kim S, Paik R, Sugino K, Kvitsiani D, Fu Y, Lu J, Lin Y, Miyoshi G, Shima Y, Fishell G, Nelson SB, Huang ZJ. A resource of cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron 2011; 71(6): 995-1013.
63. Qin, B, He M, Chen X, Pei D. Sorting nexin 10 induces giant vacuoles in mammalian cells. J Biol Chem 2006; 281(48): 36891-36896.
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